Role of Orexin-A in Hypertension and Obesity

scientific article published on April 2017

Role of Orexin-A in Hypertension and Obesity is …
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scholarly articleQ13442814

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P356DOI10.1007/S11906-017-0729-Y
P698PubMed publication ID28353077

P50authorRoberta ImperatoreQ57084157
P2093author name stringLuigia Cristino
Letizia Palomba
P2860cites workFood deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortexQ45248493
Antagonism of orexin receptors significantly lowers blood pressure in spontaneously hypertensive rats.Q46072560
Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cellsQ46659154
Orexin A regulates cardiovascular responses in stress-induced hypertensive rats.Q46982228
Emotional information processing in patients with narcolepsy: a psychophysiologic investigationQ47666148
Both Ox1r and Ox2r orexin receptors contribute to the cardiovascular and locomotor components of the novelty stress response in the rat.Q47980662
Blockade of central orexin 2 receptors reduces arterial pressure in spontaneously hypertensive ratsQ48112344
Spontaneously hypertensive rats have more orexin neurons in the hypothalamus and enhanced orexinergic input and orexin 2 receptor-associated nitric oxide signalling in the rostral ventrolateral medullaQ48117111
Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousalQ48180728
Orexin A-like immunoreactivity in the rat brainQ48264587
Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertensionQ48268840
Distribution of orexin receptor mRNA in the rat brainQ48347303
Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responsesQ48360117
Dose-different effects of orexin-A on the renal sympathetic nerve and blood pressure in urethane-anesthetized ratsQ48388966
The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglionQ48448082
Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stressQ48449697
Functional and anatomical organization of cardiovascular pressor and depressor sites in the lateral hypothalamic area: I. descending projectionsQ48547623
Impairment of sympathetic baroreceptor reflexes in obese Zucker ratsQ48572706
Distribution of orexin-1 receptor-green fluorescent protein- (OX1-GFP) expressing neurons in the mouse brain stem and pons: Co-localization with tyrosine hydroxylase and neuronal nitric oxide synthase.Q48577933
Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activitiesQ48680835
Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstemQ48689961
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesityQ48691942
Differential expression of orexin receptors 1 and 2 in the rat brainQ48693654
Hypocretin receptor protein and mRNA expression in the dorsolateral pons of ratsQ48697172
Distribution of orexin-A and orexin-B (hypocretins) in the rat spinal cordQ48718787
Orexin receptors are expressed in the adrenal medulla of the rat.Q48737843
Contribution of Orexin to the Neurogenic Hypertension in BPH/2J MiceQ48832218
Effects of leptin and orexin-A on food intake and feeding related hypothalamic neuronsQ49097264
Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord.Q50507994
Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system.Q51435079
A selective orexin-1 receptor antagonist reduces food consumption in male and female rats.Q51552390
Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting.Q51555680
Hypothalamic orexin expression: modulation by blood glucose and feeding.Q51560182
Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlates.Q53912629
Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension.Q54378215
Stress and hypertensionQ68051884
Central effects of a specific angiotensin receptor antagonist, sarthran (Sar1, Thr8AII) in normotensive and spontaneously hypertensive rat strainsQ68389565
Stress and hypertensionQ68632269
Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressinQ71277334
Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activityQ71853624
Renal sympathetic nerve activity is increased in obese Zucker ratsQ72166780
Renal denervation attenuates the sodium retention and hypertension associated with obesityQ72166811
Sympathetic and cardiovascular actions of orexins in conscious ratsQ73279189
Nervous kidney. Interaction between renal sympathetic nerves and the renin-angiotensin system in the control of renal functionQ73295548
Immunoreactive orexin-A in human plasmaQ73443069
Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized ratsQ73536652
Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastomaQ73816027
Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female ratsQ74222924
Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive ratsQ86482095
Ontogeny of angiotensin II receptorsQ41010057
Paracrine control of adrenal cortical function by medullary chromaffin cellsQ41290067
Central effects of angiotensin II in conscious hamsters: drinking, pressor response, and release of vasopressinQ41307667
Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review.Q41621710
Starvation: early signals, sensors, and sequelaeQ41687473
The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptorsQ42095193
Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascadeQ42481818
Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker ratsQ42482589
Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious ratsQ42503594
Protein distribution of the orexin-2 receptor in the rat central nervous systemQ42516895
Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptorsQ43056332
Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits.Q43145688
Sleep and cardiovascular phenotype in middle-aged hypocretin-deficient narcoleptic mice.Q43446139
Role of paraventricular nucleus in control of blood pressure and drinking in ratsQ43462623
Prolonged orexin administration stimulates steroid-hormone secretion, acting directly on the rat adrenal glandQ43545458
Central orexin-A augments sympathoadrenal outflow in conscious rabbitsQ43641685
Orexin A interactions in the hypothalamo-pituitary gonadal axisQ43802372
Pressor response to microinjection of orexin/hypocretin into rostral ventrolateral medulla of awake ratsQ43878298
Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor toneQ43888061
Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intakeQ43889435
Chronic central infusion of orexin-A increases arterial pressure in ratsQ43943097
Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleusQ43996794
Dynamics of the pituitary-adrenal ensemble in hypocretin-deficient narcoleptic humans: blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemaker.Q44204019
Cellular mechanisms of orexin actions on paraventricular nucleus neurones in rat hypothalamusQ44249839
Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptorsQ44363914
Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neuronesQ44408553
Attenuated defense response and low basal blood pressure in orexin knockout miceQ44443166
Stimulation of catecholamine synthesis by orexin-A in bovine adrenal medullary cells through orexin receptor 1.Q44485502
Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged ratsQ44528971
Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medullaQ44630163
Orexin-immunoreactive inputs to rat sympathetic preganglionic neuronsQ44635386
Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension?Q44798844
Autonomic-Immune-Vascular Interaction: An Emerging Concept for Neurogenic HypertensionQ22306336
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorQ24315738
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activityQ24317782
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPRQ24675425
Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascadeQ28142769
Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cellsQ28242384
Non-dipping blood pressure profile in narcolepsy with cataplexyQ28480931
Interactions between orexin-immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and miceQ28568671
Orexin expression and function: glucocorticoid manipulation, stress, and feeding studiesQ28570435
Central nervous system control of food intakeQ29547439
Obesity as a medical problemQ29616305
Neurons containing hypocretin (orexin) project to multiple neuronal systemsQ29619641
The orexinergic neurons receive synaptic input from C1 cells in rats.Q30365989
The sympathetic control of blood pressureQ30440682
Rostral ventrolateral medulla and sympathorespiratory integration in ratsQ30453821
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.Q30504135
Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neuronsQ30540681
Leptin and the adrenal glandQ30662008
Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tractQ31809415
Expression of Ob receptor in normal human adrenals: differential regulation of adrenocortical and adrenomedullary function by leptinQ31955805
Spectral analysis of heart rate variability reveals an enhanced sympathetic activity in narcolepsy with cataplexy.Q33534100
Interacting appetite-regulating pathways in the hypothalamic regulation of body weightQ33536761
Burden of illness review of obesity: are the true costs realised?Q33541056
Genes influencing circadian differences in blood pressure in hypertensive miceQ33889435
Obesity: are we any closer to identifying causes and effective treatments?Q34023326
Neuropeptides and obesityQ34071858
Abnormal sleep-cardiovascular system interaction in narcolepsy with cataplexy: effects of hypocretin deficiency in humansQ34216671
Hypothalamic neuropeptide mechanisms for regulating energy balance: from rodent models to human obesityQ34232242
Recent advances involving the renin-angiotensin systemQ34260674
Obesity-associated hypertension: new insights into mechanisms.Q34374149
The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisitedQ34374915
Anatomy and regulation of the central melanocortin systemQ34414149
Effects of ambient temperature on sleep and cardiovascular regulation in mice: the role of hypocretin/orexin neuronsQ34442715
Sleep related changes in blood pressure in hypocretin-deficient narcoleptic mice.Q34500449
Neuronal effects of orexins: relevant to sympathetic and cardiovascular functionsQ34519425
Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflexQ34588709
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systemsQ34854732
Cardiovascular effects of leptin and orexinsQ35061519
Neural regulation of blood pressure by leptin and the related peptidesQ35165383
Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamusQ35762656
Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflexQ36147335
Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated miceQ36436178
Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy.Q36473267
Role of orexin in modulating arousal, feeding, and motivationQ36774914
Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker ratsQ36826865
Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signalingQ36866102
Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbitsQ37143548
Orexin, orexin receptor antagonists and central cardiovascular controlQ37417966
A decade of hypocretins: past, present and future of the neurobiology of arousalQ37497427
Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward systemQ37528836
Hypocretin/orexin and energy expenditure.Q37673230
The orexin system: roles in sleep/wake regulationQ37772972
The sympathetic nervous system and blood pressure in humans: implications for hypertensionQ37898511
Orexin and central regulation of cardiorespiratory system.Q38013857
Hypocretins and the neurobiology of sleep-wake mechanismsQ38027689
Orexins, feeding, and energy balanceQ38027690
Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker ratsQ38297699
Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal glandQ38333038
Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directlyQ38344746
Hypothalamic orexin neurons regulate arousal according to energy balance in miceQ38353773
Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: A characterisation of OX1R-eGFP miceQ39021708
Hypothalamic hypocretin (orexin): robust innervation of the spinal cordQ39498726
The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.Q40324430
Functional organization of central pathways regulating the cardiovascular systemQ40746768
Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cordQ40817896
Orexins suppress catecholamine synthesis and secretion in cultured PC12 cellsQ40865974
P433issue4
P921main subjectobesityQ12174
P304page(s)34
P577publication date2017-04-01
P1433published inCurrent Hypertension ReportsQ15746362
P1476titleRole of Orexin-A in Hypertension and Obesity
P478volume19