TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells

scientific article published on April 2013

TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.431775
P932PMC publication ID3650384
P698PubMed publication ID23546880

P50authorJun Ninomiya-TsujiQ64516241
P2093author name stringMaiko Inagaki
Yuji Mishina
Kouichi Matsuzaki
Vesa Kaartinen
Robert Maxson
Mamoru Ishii
Kenji Yumoto
Manas K Ray
Jamie Lane
Penny S Thomas
Gregory J Scott
P2860cites workTGF-beta signal transductionQ22003891
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Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusionQ24294844
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent mannerQ24308947
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathwaysQ24317164
A Smad action turnover switch operated by WW domain readers of a phosphoserine codeQ27670475
Role of transforming growth factor beta in human diseaseQ28143408
Smad-dependent and Smad-independent pathways in TGF-beta family signallingQ28208250
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2Q28236792
Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathwayQ28239297
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionQ28271470
Smad transcription factorsQ28284775
Smads: transcriptional activators of TGF-beta responsesQ28292325
Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient miceQ28361871
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palateQ28506891
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defectsQ28512647
Distinct functions for Bmp signaling in lip and palate fusion in miceQ28585153
TAK1 is an essential regulator of BMP signalling in cartilageQ28586793
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palateQ28587665
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesisQ28592724
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinaseQ28628494
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinaseQ29615040
Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformationsQ33788024
TGFBR1 mutations associated with Loeys-Dietz syndrome are inactivating.Q34194428
Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signalingQ34374221
Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formationQ34543311
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signalingQ35013177
Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition.Q35025142
Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome miceQ35034373
Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis.Q35709763
Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant miceQ35780325
Regional regulation of palatal growth and patterning along the anterior-posterior axis in miceQ36325019
A stable cranial neural crest cell line from mouseQ36390173
Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue developmentQ36760321
The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.Q36980923
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-betaQ37052635
To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modificationsQ37128066
Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null miceQ37429788
Transforming growth factor-{beta}-inducible phosphorylation of Smad3Q39883712
Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growthQ39939459
TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.Q39967368
Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitorsQ40418298
Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate.Q42583187
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.Q53389037
Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesisQ74578263
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)13467-13480
P577publication date2013-04-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleTGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells
P478volume288