A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine

scientific article published on October 1996

A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/HUM.1996.7.16-1947
P698PubMed publication ID8930654

P2093author name stringHassan A
Abdallah B
Demeneix BA
Benoist C
Behr JP
Goula D
P433issue16
P304page(s)1947-1954
P577publication date1996-10-01
P1433published inHuman Gene TherapyQ15757580
P1476titleA powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine
P478volume7

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cites work (P2860)
Q39793490"Soft" calcium crosslinks enable highly efficient gene transfection using TAT peptide
Q39623131(Coixan polysaccharide)-graft-polyethylenimine folate for tumor-targeted gene delivery.
Q40269704A multifunctional PEI-based cationic polyplex for enhanced systemic p53-mediated gene therapy
Q30761899A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity
Q55518085A novel role in skeletal segment regeneration of extracellular vesicles released from periodontal-ligament stem cells.
Q48237009Accumbal 14-3-3ζ protein downregulation is associated with cocaine-conditioned memory
Q59049238Aminated β-Cyclodextrin-Modified-Carboxylated Magnetic Cobalt/Nanocellulose Composite for Tumor-Targeted Gene Delivery
Q35091789Application of magnetic nanoparticles to gene delivery
Q38264536Applications of nanoparticle systems in gene delivery and gene therapy
Q39847510Arginine-based cationic liposomes for efficient in vitro plasmid DNA delivery with low cytotoxicity
Q39996530BMP-2 decreases Mash1 stability by increasing Id1 expression
Q36120376BMP-2 gene modified canine bMSCs promote ectopic bone formation mediated by a nonviral PEI derivative
Q35572475BMP2 gene delivery to bone mesenchymal stem cell by chitosan-g-PEI nonviral vector
Q39325592Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency
Q54414411Brain-derived neurotrophic factor enhances Bcl-xL expression through protein kinase casein kinase 2-activated and nuclear factor kappa B-mediated pathway in rat hippocampus.
Q40606300CMV enhancer/human PDGF-beta promoter for neuron-specific transgene expression
Q42454485CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes
Q28570664CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory
Q42812392Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
Q34980920Cationic lipid-DNA complexes-lipoplexes-for gene transfer and therapy
Q40816119Cationic lipids and polymers are able to enhance adenoviral infection of cultured mouse myotubes
Q36792080Cationic, amphiphilic copolymer micelles as nucleic acid carriers for enhanced transfection in rat spinal cord
Q40788007Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer
Q35587466Characterization and evaluation of the efficacy of cationic complex mediated plasmid DNA delivery in human embryonic palatal mesenchyme cells
Q73154559Characterization of commercially available and synthesized polyethylenimines for gene delivery
Q34019309Characterization of polyethylenimine by electrospray ionization and matrix-assisted laser desorption/ionization
Q37015807Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo
Q40783246Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo
Q39564323Co-delivery of anti-vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression
Q35853451Combinatorial Approach to Nanoarchitectonics for Nonviral Delivery of Nucleic Acids
Q34445374Comparative studies of polyethylenimine-doxorubicin conjugates with pH-sensitive and pH-insensitive linkers.
Q40905791Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs
Q51433875Complex Coacervation-Integrated Hybrid Nanoparticles Increasing Plasmid DNA Delivery Efficiency in Vivo.
Q51079230Complexation and synergistic boundary lubrication of porcine gastric mucin and branched poly(ethyleneimine) in neutral aqueous solution.
Q58324590Controlled Release of DNA From Photoresponsive Hyperbranched Polyglycerols with Oligoamine Shells
Q35620922Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide
Q41878557Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine
Q39618953Cyclic RGD-poly(ethylene glycol)-polyethyleneimine is more suitable for glioblastoma targeting gene transfer in vivo
Q33933473Cytosolic drug delivery using pH- and light-sensitive liposomes
Q37095873DNA delivery from matrix metalloproteinase degradable poly(ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells
Q40158054DNA delivery to the mitochondria sites using mitochondrial leader peptide conjugated polyethylenimine
Q42826272DNA transfection using linear poly(ethylenimine) prepared by controlled acid hydrolysis of poly(2-ethyl-2-oxazoline).
Q33181420DNA-Dependent protein kinase is not required for efficient lentivirus integration
Q42104292DNA/polyethylenimine transfection particles: influence of ligands, polymer size, and PEGylation on internalization and gene expression
Q37240292De novo induction of genetically engineered brain tumors in mice using plasmid DNA
Q38912667Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives
Q39720053Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrier
Q34293708Delivery of siRNA therapeutics: barriers and carriers
Q44233126Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression
Q36631534Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo
Q42110886Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs
Q36211579Design and development of polymers for gene delivery
Q34463671Design and gene delivery activity of modified polyethylenimines.
Q40899216Development of transferrin-polycation/DNA based vectors for gene delivery to melanoma cells
Q39305856Dexamethasone conjugation to polyamidoamine dendrimers G1 and G2 for enhanced transfection efficiency with an anti-inflammatory effect
Q40601197Dextran-spermine polycation: an efficient nonviral vector for in vitro and in vivo gene transfection
Q44315150Different synergistic roles of small polyethylenimine and Dosper in gene delivery.
Q43017198Discovery of antibiotics-derived polymers for gene delivery using combinatorial synthesis and cheminformatics modeling
Q31120377Distribution and quantification of polyethylenimine oligodeoxynucleotide complexes in human skin after iontophoretic delivery using confocal scanning laser microscopy.
Q37221056Dual-degradable disulfide-containing PEI-Pluronic/DNA polyplexes: transfection efficiency and balancing protection and DNA release
Q57348244Dually stimuli-responsive hyperbranched polyethylenimine with LCST transition based on hydrophilic-hydrophobic balance
Q50512880Ectopic study of calcium phosphate cement seeded with pBMP-2 modified canine bMSCs mediated by a non-viral PEI derivative.
Q36658314Efficacy of nonviral gene transfer in the canine brain
Q46731722Efficient Gene Transfection into Mammalian Cells Mediated by Cross-linked Polyethylenimine
Q41915846Efficient gene delivery to primary neuron cultures using a synthetic peptide vector system
Q36580613Emerging vectors and targeting methods for nonviral gene therapy.
Q37702252Endosomal disruptors in non-viral gene delivery
Q43918970Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector
Q38297233Experimental design, modeling and optimization of polyplex formation between DNA oligonucleotides and branched polyethylenimine.
Q36259512FGF2 gene activated matrices promote proliferation of bone marrow stromal cells
Q42833955Fabrication and in vitro testing of polymeric delivery system for condensed DNA
Q28572333Focal adhesion kinase is required, but not sufficient, for the induction of long-term potentiation in dentate gyrus neurons in vivo
Q40693995Formation of plasmid-based transfection complexes with an acid-labile cationic lipid: characterization of in vitro and in vivo gene transfer
Q44528873Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles.
Q36778996GDNF gene delivery via a 2-(dimethylamino)ethyl methacrylate based cyclized knot polymer for neuronal cell applications
Q38661342Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation
Q40268859Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles
Q38297124Gene therapy and imaging in preclinical and clinical oncology: recent developments in therapy and theranostics
Q41558472Gene therapy for chronic viral hepatitis: ribozymes, antisense oligonucleotides, and dominant negative mutants
Q34996908Gene therapy for genetic and acquired retinal diseases
Q44485844Gene transfer to dorsal root ganglia by intrathecal injection: effects on regeneration of peripheral nerves
Q30874932Gene transfer with lipospermines and polyethylenimines
Q52316104Hexadecylated linear PEI self-assembled nanostructures as efficient vectors for neuronal gene delivery.
Q40872035Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer.
Q40532549Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers
Q45861880Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency
Q97438364In vivo gene delivery mediated by non-viral vectors for cancer therapy
Q57020987In vivo methods for acute modulation of gene expression in the central nervous system
Q74310269In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides
Q34474842Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds
Q48337696Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells
Q38074461Inspired by nature: fundamentals in nanotechnology design to overcome biological barriers.
Q50583477Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy.
Q40528544Integration and long-term expression in xenografted human glioblastoma cells using a plasmid-based transposon system
Q40980544Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies
Q74603708Intracellular route and transcriptional competence of polyethylenimine-DNA complexes
Q35555581Intracellular trafficking of polyamidoamine-poly(ethylene glycol) block copolymers in DNA delivery
Q40372570Intraperitoneal linear polyethylenimine (L-PEI)-mediated gene delivery to ovarian carcinoma nodes in mice
Q42095035Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain
Q35356850Laminin-β1 impairs spatial learning through inhibition of ERK/MAPK and SGK1 signaling
Q30493188Magnetic nanoparticles for gene and drug delivery.
Q38012538Magnetic targeting and ultrasound mediated drug delivery: benefits, limitations and combination
Q36549401MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
Q41566501Metabolically stabilized long-circulating PEGylated polyacridine peptide polyplexes mediate hydrodynamically stimulated gene expression in liver.
Q36287041Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain
Q39646936Modified polyethyleneimine with histidine–lysine short peptides as gene carrier
Q40669107Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver
Q37180831Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios
Q28590361Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1
Q39119319Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles
Q64906119Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β.
Q37615651Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice
Q36842707Non-viral gene delivery: from the needle to the nucleus
Q39660840Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice
Q36425890Non-viral therapeutic approaches to ocular diseases: An overview and future directions
Q36969152Nonviral approaches for neuronal delivery of nucleic acids.
Q37099839Nonviral gene transfection nanoparticles: function and applications in the brain
Q37805489Nonviral vectors for the delivery of small interfering RNAs to the CNS.
Q38722859Novel PEI/Poly-γ-Gutamic Acid Nanoparticles for High Efficient siRNA and Plasmid DNA Co-Delivery
Q46777940Novel cationic copolymers of a polyasparthylhydrazide: synthesis and characterization
Q34485736Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning
Q30694800Novel water insoluble lipoparticulates for gene delivery
Q77739930Oligonucleotide-mediated site-directed gene repair
Q30840523Optimisation of polyethylenimine-based gene delivery to mouse brain.
Q37681182Optimizing the transient transfection process of HEK-293 suspension cells for protein production by nucleotide ratio monitoring
Q63972376PDMAEMA based gene delivery materials
Q40931003PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
Q42802517Parallel Synthesis and Biophysical Characterization of a Degradable Polymer Library for Gene Delivery
Q40523659Partial acetylation of polyethylenimine enhances in vitro gene delivery.
Q24646738Pathological and protective roles of glia in chronic pain
Q99724582Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain
Q34180767Pharmacological aspects of targeting cancer gene therapy to endothelial cells
Q44378483Physicochemical and biological evaluation of cationic polymethacrylates as vectors for gene delivery
Q33698747Poly(ethylenimine) and its role in gene delivery
Q40642378Polycation liposome-mediated gene transfer in vivo
Q45869587Polycation liposomes, a novel nonviral gene transfer system, constructed from cetylated polyethylenimine
Q44406323Polyethylene glycol modified polyethylenimine for improved CNS gene transfer: effects of PEGylation extent
Q40740217Polyethyleneimine-based immunopolyplex for targeted gene transfer in human lymphoma cell lines
Q24796341Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina
Q30801495Polyethylenimine (PEI).
Q46834268Polyethylenimine nanoparticles as efficient transfecting agents for mammalian cells
Q40044120Polyethylenimine-DNA solid particles for gene delivery
Q41985187Polyethylenimine-mediated gene delivery to the lung and therapeutic applications.
Q45876626Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity
Q45877889Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application
Q38110474Polyethylenimines for siRNA and miRNA delivery in vivo
Q37002661Polymers for DNA delivery.
Q45863670Polyplex-mediated gene transfer into human retinal pigment epithelial cells in vitro
Q35189737Preparation of poly(β-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery
Q43796875Prolonged organ retention and safety of plasmid DNA administered in polyethylenimine complexes
Q45297193Prospectives for cell and gene therapy in Huntington's disease
Q34804863Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
Q45988287Protein kinase CK2 enhances Mcl-1 gene expression through the serum response factor-mediated pathway in the rat hippocampus.
Q51974609Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1.
Q89462180Quantitating Endosomal Escape of a Library of Polymers for mRNA Delivery
Q40437826Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes
Q46875535RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling
Q38253654RETRACTED: Recent trends of polymer mediated liposomal gene delivery system.
Q47692544RLU and studies using the luciferase reporter gene
Q43583256Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine
Q34076933Receptor-mediated targeting of gene delivery vectors: insights from molecular mechanisms for improved vehicle design
Q42176571Reducible, dibromomaleimide-linked polymers for gene delivery
Q45863310Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord
Q40785121Role of endocytosis in the transfection of L929 fibroblasts by polyethylenimine/DNA complexes
Q28582941SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression
Q90216600Self-Assembled Nanoparticles Prepared from Low-Molecular-Weight PEI and Low-Generation PAMAM for EGFRvIII-Chimeric Antigen Receptor Gene Loading and T-Cell Transient Modification
Q48041220Sequence and characterisation of the RET proto-oncogene 5' flanking region: analysis of retinoic acid responsiveness at the transcriptional level.
Q40034016Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation.
Q28192320Side-effects of a systemic injection of linear polyethylenimine-DNA complexes
Q40943284Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle
Q35742331Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
Q45887753Somatic gene transfer into the lactating ovine mammary gland
Q44263349Spectrophotometric determination of polyethylenimine in the presence of an oligonucleotide for the characterization of controlled release formulations
Q40321762Successful in vivo tumor targeting of prostate-specific membrane antigen with a highly efficient J591/PEI/DNA molecular conjugate
Q64899804Suicide Gene Therapy By Amphiphilic Copolymer Nanocarrier for Spinal Cord Tumor.
Q58691061Surface Modification of Gelatin Nanoparticles with Polyethylenimine as Gene Vector
Q44378505Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells
Q36015641Targeted nanoparticles enhanced flow electroporation of antisense oligonucleotides in leukemia cells
Q36416427Targeted polymeric nanoparticles for cancer gene therapy
Q50769086Targeting Promoter-Associated Noncoding RNA In Vivo.
Q50474775The Involvement of the Decrease of Astrocytic Wnt5a in the Cognitive Decline in Minimal Hepatic Encephalopathy.
Q40169132The Shb signalling scaffold binds to and regulates constitutive signals from the Epstein-Barr virus LMP2A membrane protein
Q64922023The Use of ex Vivo Rodent Platforms in Neuroscience Translational Research With Attention to the 3Rs Philosophy.
Q42251504The effect of cationic charge density change on transfection efficiency of polyethylenimine
Q35748080The effect of glycosaminoglycan content on polyethylenimine-based gene delivery within three-dimensional collagen-GAG scaffolds
Q24631224The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor
Q35071074The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis
Q91595608The synthesis, properties and potential applications of cyclic polymers
Q43947690The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures
Q30635311Thyroid hormone effects on Krox-24 transcription in the post-natal mouse brain are developmentally regulated but are not correlated with mitosis
Q45862949Tissue-dependent factors affect gene delivery to tumors in vivo
Q36339428Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery
Q39849558Transfection efficiency of 25-kDa PEI-cholesterol conjugates with different levels of modification
Q34056573Translocating peptides and proteins and their use for gene delivery.
Q44345846Tumor regression by repeated intratumoral delivery of water soluble lipopolymers/p2CMVmIL-12 complexes
Q45888469Tumour gene expression from C12 spermine amphiphile gene delivery systems
Q34091796Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds
Q45872837Ultrasound- and liposome microbubble-mediated targeted gene transfer to cardiomyocytes in vivo accompanied by polyethylenimine.
Q48315993Up- and down-expression of the dopamine transporter by plasmid DNA transfer in the rat brain
Q33798105Use of polyethylenimine-modified magnetic nanoparticles for highly specific enrichment of phosphopeptides for mass spectrometric analysis
Q41771315Utilizing cell-matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels
Q34518719Vehicles for oligonucleotide delivery to tumours
Q45882273Water-soluble lipopolymer as a gene carrier to corpus cavernosum
Q40662542Water-soluble lipopolymer as an efficient carrier for gene delivery to myocardium
Q37284978Women and heart disease--physiologic regulation of gene delivery and expression: bioreducible polymers and ischemia-inducible gene therapies for the treatment of ischemic heart disease
Q28583307sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats

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