The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial

scientific article published on February 2008

The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1055-9965.EPI-07-0658
P932PMC publication ID2515594
P698PubMed publication ID18268112
P5875ResearchGate publication ID5584268

P50authorThomas E AhleringQ46075903
Frank L. Meyskens, Jr.Q22006852
Hoda Anton-CulverQ28052887
Argyrios ZiogasQ30831638
P2093author name stringChristine E McLaren
Eugene W Gerner
Ronald Lieberman
Thomas E Ahlering
Ray Nagle
Anne R Simoneau
Sharon Fujikawa-Brooks
Hagit Yerushalmi
P2860cites workChemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trialQ45062085
The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivationQ45169840
Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3.Q45238922
Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polypsQ46301309
Differences in ornithine decarboxylase and androgen receptor allele frequencies among ethnic groupsQ46672639
A randomized, placebo-controlled trial of low-dose alpha-difluoromethylornithine in individuals at risk for colorectal cancer.Q50503298
Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with alpha-difluoromethylornithine.Q53471823
Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa.Q53479543
Cell transformation, invasion, and angiogenesis: a regulatory role for ornithine decarboxylase and polyamines?Q53753522
Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme.Q54032299
Polyamine contents in rectal and buccal mucosae in humans treated with oral difluoromethylornithineQ54277312
SELECT: the next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention Trial.Q55035197
Androgen regulation of ornithine decarboxylase in human prostatic cells identified using differential displayQ63966054
High-performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivativesQ70730581
Copenhagen rat prostatic tumor ornithine decarboxylase activity (ODC) and the effect of the ODC inhibitor alpha-difluoromethylornithineQ71621379
The development of human benign prostatic hyperplasia with ageQ72743475
Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP miceQ73034159
Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithineQ73355841
Predictors of mortality after androgen-deprivation therapy in patients with rapidly rising prostate-specific antigen levels after local therapy for prostate cancerQ79776932
Predictors of prostate cancer-specific mortality after radical prostatectomy or radiation therapyQ81280205
Pretreatment predictors of posttreatment PSA doubling times for patients undergoing three-dimensional conformal radiotherapy for clinically localized prostate cancerQ81476462
A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor geneQ28194213
Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase geneQ28196474
Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma preventionQ28200776
Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiformeQ31861401
Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomasQ33346905
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylaseQ33392926
Polyamines and cancer: old molecules, new understandingQ34362757
The influence of finasteride on the development of prostate cancerQ34534815
The ageing male: demographics and challengesQ34712021
Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatmentQ35645345
Polyamines as clinical laboratory toolsQ35776575
Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemopreventionQ36775315
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseasesQ36803757
Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference rangesQ39377735
Altered polyamine profiles in prostatic hyperplasia and in kidney tumorsQ39496435
Polyamines in normal and cancer cellsQ39597954
Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trialsQ40939818
Effect of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissuesQ41512785
Polyamines in the male reproductive system.Q41530814
Effects of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated ratsQ42065740
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trialQ43514966
Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissionsQ43603023
Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer.Q43860642
A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkersQ44175750
Chemoprevention of prostate carcinogenesis by DFMO and/or finasteride treatment in male Wistar rats.Q44322483
Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survivalQ44407580
Association among an ornithine decarboxylase polymorphism, androgen receptor gene (CAG) repeat length and prostate cancer riskQ44721022
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer preventionQ44788424
Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP miceQ44976886
P433issue2
P921main subjectplaceboQ269829
P304page(s)292-299
P577publication date2008-02-01
P1433published inCancer Epidemiology, Biomarkers & PreventionQ326334
P1476titleThe effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial
P478volume17

Reverse relations

cites work (P2860)
Q36457059A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity
Q33608811A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation.
Q51135191Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats.
Q37403674Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival
Q37681944Cancer chemoprevention locks onto a new polyamine metabolic target
Q35595617Cellular diamine levels in cancer chemoprevention: modulation by ibuprofen and membrane plasmalogens
Q26471702Chemoprevention agents for prostate cancer
Q64997513Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity.
Q36838564Current status of the polyamine research field
Q35583635DFMO: targeted risk reduction therapy for colorectal neoplasia
Q37679982Design of polyamine-based therapeutic agents: new targets and new directions
Q34763431Diagnosis of prostate cancer using differentially expressed genes in stroma
Q38765477Difluoromethylornithine in cancer: new advances
Q33859016Difluoromethylornithine: the proof is in the polyamines
Q33883491Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase
Q39838831Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.
Q39935779Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma
Q35027354Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling
Q37570555Emerging drugs for prostate cancer
Q37543114Enhanced evaluation of selective androgen receptor modulators in vivo.
Q38957285Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells
Q39844175Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047.
Q39498622Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer
Q26740548One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling
Q38738879Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling
Q46636207Ornithine decarboxylase as a therapeutic target for endometrial cancer
Q63681549PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness
Q91675188Polyamine Depletion Inhibits Bunyavirus Infection via Generation of Noninfectious Interfering Virions
Q41107342Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma.
Q26864516Polyamines and cancer: implications for chemotherapy and chemoprevention
Q38315056Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells
Q38257840Polyamines metabolism and breast cancer: state of the art and perspectives
Q34371057Prevention and early detection of prostate cancer
Q37522449Recent advances in the development of polyamine analogues as antitumor agents
Q36958356Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice
Q30484125Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine
Q38474358Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma
Q36653461Targeting polyamines and inflammation for cancer prevention
Q33761692The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

Search more.