| scholarly article | Q13442814 |
| P50 | author | Lyle L Moldawer | Q92147747 |
| Matthew J. Delano | Q42554493 | ||
| James L Wynn | Q47503963 | ||
| P2093 | author name string | Ofer Levy | |
| Philip O Scumpia | |||
| Robert D Winfield | |||
| Tolga Barker | |||
| Ricardo Ungaro | |||
| Kindra Kelly-Scumpia | |||
| P2860 | cites work | Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 | Q24310398 |
| A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection | Q24646925 | ||
| Pathogen recognition and innate immunity | Q27861084 | ||
| Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway | Q28216760 | ||
| Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis | Q28585138 | ||
| Effect of a novel topical immunomodulator, S-28463, on keratinocyte cytokine gene expression and production | Q71605650 | ||
| Lymphocyte subpopulations in full-term septic neonates | Q73103198 | ||
| Monocyte deactivation in septic patients: restoration by IFN-gamma treatment | Q73400029 | ||
| Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans | Q73896312 | ||
| Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover | Q74303609 | ||
| Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection | Q74754482 | ||
| Depletion of dendritic cells, but not macrophages, in patients with sepsis | Q77671545 | ||
| Neonatal adaptive immunity comes of age | Q80270958 | ||
| T cell activation by TLRs: a role for TLRs in the adaptive immune response | Q81039397 | ||
| Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells | Q28594415 | ||
| The epidemiology of sepsis in the United States from 1979 through 2000 | Q29547760 | ||
| Dysregulation of in vitro cytokine production by monocytes during sepsis | Q34211246 | ||
| 4 million neonatal deaths: when? Where? Why? | Q34400748 | ||
| Imiquimod and resiquimod as novel immunomodulators | Q34457001 | ||
| Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis | Q34581804 | ||
| Activation of common antiviral pathways can potentiate inflammatory responses to septic shock | Q34885791 | ||
| Toll-like receptors induce a phagocytic gene program through p38. | Q35834699 | ||
| Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells | Q35849930 | ||
| Neonatal T cell function | Q36086833 | ||
| Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells | Q36229355 | ||
| MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis | Q36229458 | ||
| Type I interferon production enhances susceptibility to Listeria monocytogenes infection | Q36399599 | ||
| Type I interferon dependence of plasmacytoid dendritic cell activation and migration. | Q36403406 | ||
| Necrotising enterocolitis | Q36617416 | ||
| Adaptive immune cells temper initial innate responses | Q36731614 | ||
| Innate immunity of the newborn: basic mechanisms and clinical correlates | Q36800979 | ||
| Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists | Q36811131 | ||
| Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance | Q40085281 | ||
| Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides | Q40212635 | ||
| Sepsis in neonates and children: definitions, epidemiology, and outcome. | Q41589972 | ||
| Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. | Q42468030 | ||
| Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. | Q42767187 | ||
| Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation | Q43737915 | ||
| Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines | Q44119028 | ||
| Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response | Q44428306 | ||
| Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses | Q44521235 | ||
| Interleukin 6 as early mediator in neonatal sepsis | Q44583920 | ||
| Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis | Q44639646 | ||
| Type I IFN modulates host defense and late hyperinflammation in septic peritonitis. | Q44749093 | ||
| Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte | Q45018156 | ||
| CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus. | Q53629031 | ||
| Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis. | Q53850410 | ||
| CpG oligodeoxynucleotides enhance neonatal resistance to Listeria infection. | Q53875128 | ||
| TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. | Q54439429 | ||
| Gene-specific control of inflammation by TLR-induced chromatin modifications | Q59065852 | ||
| Control of B-cell responses by Toll-like receptors | Q59066168 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | sepsis | Q183134 |
| toll-like receptor | Q408004 | ||
| P304 | page(s) | 1750-1758 | |
| P577 | publication date | 2008-06-30 | |
| P1433 | published in | Blood | Q885070 |
| P1476 | title | Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists | |
| P478 | volume | 112 |
| Q27321672 | A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses |
| Q37624325 | A prime time for trained immunity: innate immune memory in newborns and infants. |
| Q48157738 | Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation. |
| Q35911931 | Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants. |
| Q37407684 | An Immunological Perspective on Neonatal Sepsis. |
| Q41516125 | An impaired inflammatory cytokine response to gram-negative LPS in human neonates is associated with the defective TLR-mediated signaling pathway |
| Q27021053 | Arginine depletion increases susceptibility to serious infections in preterm newborns |
| Q59486987 | Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis |
| Q90697733 | BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny |
| Q42706724 | CD4+ T cells are not essential for control of early acute Cryptosporidium parvum infection in neonatal mice. |
| Q34911516 | Cardiac function and circulating cytokines after endotoxin exposure in neonatal mice |
| Q89505794 | Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis |
| Q28475947 | Cellular and molecular mechanisms underlying the strong neonatal IL-12 response of lamb mesenteric lymph node cells to R-848 |
| Q38212484 | Challenges in vaccination of neonates, infants and young children |
| Q35012945 | Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency |
| Q36852546 | Could Biomarkers Direct Therapy for the Septic Patient? |
| Q35328903 | Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. |
| Q57284692 | Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality |
| Q35060860 | Delayed emergency myelopoiesis following polymicrobial sepsis in neonates |
| Q38675239 | Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease |
| Q36756012 | Early sepsis does not increase the risk of late sepsis in very low birth weight neonates |
| Q43615027 | Effects of age and R848 stimulation on expression of Toll-like receptor 8 mRNA by foal neutrophils |
| Q92425388 | Effects of immunotherapy on mortality in neonates with suspected or proven sepsis: a systematic review and network meta-analysis |
| Q91824488 | Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis |
| Q57922233 | Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis |
| Q43198361 | Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis |
| Q40321050 | Estradiol and thermoregulation in adult endotoxemic rats exposed to lipopolysaccharide in neonatal life |
| Q36735992 | Genome-wide expression profiling in pediatric septic shock |
| Q90413444 | Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis |
| Q37061098 | Harnessing the beneficial heterologous effects of vaccination |
| Q26864779 | Heterologous ("nonspecific") and sex-differential effects of vaccines: epidemiology, clinical trials, and emerging immunologic mechanisms |
| Q40696555 | Heterologous vaccine effects |
| Q33941919 | Human Neonatal Peripheral Blood Leukocytes Demonstrate Pathogen-Specific Coordinate Expression of TLR2, TLR4/MD2, and MyD88 During Bacterial Infection In Vivo |
| Q36826887 | Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis |
| Q46583824 | IL-17 in neonatal health and disease |
| Q36389045 | Immunization of pregnant women: Future of early infant protection |
| Q37627158 | Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches. |
| Q57175340 | Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future |
| Q38660625 | Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease. |
| Q88886241 | Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production |
| Q35782203 | Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2. |
| Q37262438 | Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. |
| Q41482261 | Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation |
| Q42275242 | Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection |
| Q36511529 | Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly |
| Q37680770 | Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines |
| Q38061668 | Innate immune responses against Cryptosporidium parvum infection. |
| Q37766905 | Innate immunity in human newborn infants: prematurity means more than immaturity. |
| Q37239351 | Interleukin 27 as a sepsis diagnostic biomarker in critically ill adults |
| Q46380926 | Intraperitoneal gardiquimod protects against hepatotoxicity through inhibition of oxidative stress and inflammation in mice with sepsis |
| Q40250597 | LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production. |
| Q52672346 | Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats. |
| Q36818068 | Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis |
| Q34630952 | Maternal vaccination: moving the science forward |
| Q37353938 | Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model. |
| Q99711536 | Maturation of the Acute Hepatic TLR4/NF-κB Mediated Innate Immune Response Is p65 Dependent in Mice |
| Q38690754 | Murine Models of Sepsis and Trauma: Can We Bridge the Gap? |
| Q35864705 | Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality. |
| Q52579157 | Neonatal Immunization: Rationale, Current State, and Future Prospects. |
| Q26823812 | Neonatal host defense against Staphylococcal infections |
| Q34758294 | Neonatal immune adaptation of the gut and its role during infections |
| Q38648972 | Neurological consequences of systemic inflammation in the premature neonate |
| Q33730288 | Neutrophil and endothelial adhesive function during human fetal ontogeny |
| Q30419805 | Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling |
| Q47665126 | Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen |
| Q34464971 | Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis. |
| Q27000632 | Ontogeny of early life immunity |
| Q55014943 | Outgrowing the Immaturity Myth: The Cost of Defending From Neonatal Infectious Disease. |
| Q33940492 | Pathophysiology and treatment of septic shock in neonates. |
| Q34076339 | Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. |
| Q37980790 | Perspectives on immunomodulation early in life. |
| Q47583345 | Poly(I:C) Priming Exacerbates Cecal Ligation and Puncture-Induced Polymicrobial Sepsis in Mice |
| Q28569467 | Postnatal development of hepatic innate immune response |
| Q37260284 | Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis. |
| Q90069519 | Prognostic and predictive enrichment in sepsis |
| Q38058122 | Progress in the field of necrotising enterocolitis--year 2012. |
| Q36223575 | Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis |
| Q37667952 | Protective immunity and defects in the neonatal and elderly immune response to sepsis |
| Q35152743 | Ready to benefit from training: heterologous effects of early life immunization |
| Q33940417 | Role of innate host defenses in susceptibility to early-onset neonatal sepsis. |
| Q26999064 | Role of innate immunity in neonatal infection |
| Q33941032 | Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. |
| Q37189501 | Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine |
| Q51537067 | Stimulation of TLR7 prior to polymicrobial sepsis improves the immune control of the inflammatory response in adult mice. |
| Q34980381 | TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis |
| Q36905009 | Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18. |
| Q35191988 | The Toll-like receptor 4 agonist monophosphoryl lipid a augments innate host resistance to systemic bacterial infection |
| Q47602497 | The biology of natural killer cells during sepsis. |
| Q36016375 | The developing human preterm neonatal immune system: a case for more research in this area. |
| Q33950741 | The host response to sepsis and developmental impact |
| Q35876790 | The influence of developmental age on the early transcriptomic response of children with septic shock |
| Q39014478 | The neonatal immune system: immunomodulation of infections in early life |
| Q37073999 | Toll-Like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice. |
| Q35570164 | Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants |
| Q38161561 | Toll-like receptor signaling in neonatal sepsis and inflammation: a matter of orchestration and conditioning |
| Q92434451 | Toward precision adjuvants: optimizing science and safety |
| Q40278317 | Treatment with milk fat globule epidermal growth factor-factor 8 (MFG-E8) reduces inflammation and lung injury in neonatal sepsis |
| Q36291304 | Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis |
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