Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation

scientific article published on 20 April 2016

Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/NU8040231
P932PMC publication ID4848699
P698PubMed publication ID27104563

P50authorJianzhong XuQ51024336
Ce DouQ58914412
P2093author name stringHong Jiang
Min Hu
Fei Luo
Zhen Cao
Shiwu Dong
Ning Ding
Fei Kang
Tianyong Hou
Zhao Xie
Xiaochao Yang
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
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From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosisQ28385120
Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS productionQ28535889
A new superoxide-generating oxidase in murine osteoclastsQ28587361
Osteoclast differentiation and activationQ29547556
Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory?Q30368268
FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulationQ33587373
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivoQ34244296
Update on denosumab in postmenopausal osteoporosis--recent clinical dataQ34300462
Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathwaysQ34386876
MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation.Q53473415
Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitinationQ85295108
Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynaminQ85841218
Dual Effect of Cyanidin on RANKL-Induced Differentiation and Fusion of OsteoclastsQ86419329
Cordycepin (3'-deoxyadenosine) down-regulates the proinflammatory cytokines in inflammation-induced osteoporosis modelQ87226184
Cordycepin (3'-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in ratsQ87353386
Calcium metabolism and oxidative stress in bone fractures: role of antioxidants.Q34640274
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The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signalingQ37095379
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesisQ37259220
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Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesisQ37370702
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JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life spanQ37447693
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p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agentsQ38170919
The inhibition of RANK-ligand in the management of postmenopausal osteoporosis and related fractures: the role of denosumabQ38193181
Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generationQ38466415
Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in MacrophagesQ38488996
Nuclear Nrf2 induction by protein transduction attenuates osteoclastogenesisQ38956349
Cordycepin induces S phase arrest and apoptosis in human gallbladder cancer cells.Q38968922
Fluid flow-induced calcium response in osteoclasts: signaling pathwaysQ39006749
Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species‑mediated mitochondrial death pathwayQ39215740
Cordycepin inhibits albumin-induced epithelial-mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species productionQ39431747
Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cellsQ39594556
High oxygen tension prolongs the survival of osteoclast precursors via macrophage colony-stimulating factorQ39923235
Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation.Q40317083
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.Q40493379
An essential role for free radicals and derived species in signal transduction.Q41353458
Nrf2 regulates ROS production by mitochondria and NADPH oxidaseQ41883957
Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury.Q42237002
Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytesQ44223897
Reactive oxygen species mediate RANK signaling in osteoclasts.Q45142284
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiationQ46427712
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P304page(s)231
P577publication date2016-04-20
P1433published inNutrientsQ7070485
P1476titleCordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation
P478volume8

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cites work (P2860)
Q91045130A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin
Q58553046Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro
Q92642434Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
Q47137712Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE-/- mice.
Q52331539Graphene-Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization.
Q47100432Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen
Q33851991Osthole Enhances Osteogenesis in Osteoblasts by Elevating Transcription Factor Osterix via cAMP/CREB Signaling In Vitro and In Vivo.
Q91942005Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss
Q64082993The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis
Q92815759Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi

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