The proteome of schizophrenia

scientific article published on 4 March 2015

The proteome of schizophrenia is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/NPJSCHZ.2014.3
P932PMC publication ID4849438
P698PubMed publication ID27336025
P5875ResearchGate publication ID276407208

P50authorJuliana Minardi NascimentoQ37368289
Daniel Martins-de-SouzaQ28678599
P2860cites workDisease biomarkers in cerebrospinal fluid of patients with first-onset psychosisQ21144689
Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulationQ21260256
Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with MitofilinQ24301405
Biological insights from 108 schizophrenia-associated genetic lociQ24561833
High resolution two-dimensional electrophoresis of proteinsQ24608190
Common variants conferring risk of schizophreniaQ24614376
Modelling schizophrenia using human induced pluripotent stem cellsQ24633007
Genome-scale neurogenetics: methodology and meaningQ26859474
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomicsQ28131742
Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortexQ28138248
Genome-wide association study identifies five new schizophrenia lociQ28248384
Common polygenic variation contributes to risk of schizophrenia and bipolar disorderQ28250609
Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissuesQ28253419
A first step toward completion of a genome-wide characterization of the human proteomeQ45740688
Quantitative profiling of proteins in complex mixtures using liquid chromatography and mass spectrometry.Q45997049
A comparative proteomics analysis of rat mitochondria from the cerebral cortex and hippocampus in response to antipsychotic medications.Q46012495
Targeted proteomicsQ46143284
2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric diseaseQ46661063
Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia.Q47383429
Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem studyQ47900194
2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophreniaQ48319021
Quintessence from proteomics networks--the HUPO Brain Proteome Project Pilot StudiesQ48422993
Protein phosphorylation patterns in serum from schizophrenia patients and healthy controlsQ48526200
Global proteomic profiling reveals altered proteomic signature in schizophrenia serumQ48536502
A proteome analysis of the anterior cingulate cortex gray matter in schizophreniaQ48642132
Proteomic and genomic evidence implicates the postsynaptic density in schizophreniaQ48646111
Anterior hippocampus in schizophrenia pathogenesis: molecular evidence from a proteome studyQ48698691
Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patientQ48860052
Proteomic approaches to unravel the complexity of schizophreniaQ37980246
Proteomic analysis of cell fate decisionQ38128685
The role of anti-inflammatory treatment in psychiatric disorders.Q38139245
Next-generation sequencing in schizophrenia and other neuropsychiatric disordersQ38153345
The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patientsQ38170139
Myelination and oligodendrocyte functions in psychiatric diseasesQ38199654
2DE: the phoenix of proteomics.Q38202467
The synapse in schizophreniaQ38203024
The emergence of proteome-wide technologies: systematic analysis of proteins comes of age.Q38221025
Modeling hippocampal neurogenesis using human pluripotent stem cellsQ38460557
MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene setsQ38989183
Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatmentQ39242341
Perturbation in mitochondrial network dynamics and in complex I dependent cellular respiration in schizophreniaQ39577276
Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjectsQ39664112
Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia.Q39791733
Mitochondrial complex I as a novel target for intraneuronal DA: modulation of respiration in intact cellsQ39850480
Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophreniaQ39928887
Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophreniaQ40834916
Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it.Q41248468
Synaptic dysregulation in a human iPS cell model of mental disordersQ41534293
Proteomics tackling schizophrenia as a pathway disorder.Q42352224
Activation of brain interleukin-1beta in schizophrenia.Q42852301
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophreniaQ43062918
Different apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase levels in cerebrospinal fluid of schizophrenia patients and healthy controlsQ43072099
Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patientsQ43185085
Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia.Q43940200
Targeted proteomics for validation of biomarkers in early psychosisQ44138872
Identification and validation of platelet low biological variation proteins, superior to GAPDH, actin and tubulin, as tools in clinical proteomics.Q44773945
Distinct cerebrospinal fluid amyloid-beta peptide signatures in cognitive decline associated with Alzheimer's disease and schizophrenia.Q45420612
Perspective: Revealing molecular secrets.Q50651034
Quantification of Proteins by Label-Free LC-MS/MSQ51661501
The human proteome project: Current state and future direction.Q51711697
Using our brains: the findings, flaws, and future of postmortem studies of psychiatric disorders.Q51770691
Characterization of salivary proteins of schizophrenic and bipolar disorder patients by top-down proteomics.Q53059728
iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia.Q54530327
The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome.Q55055789
Isoelectric focusing in immobilized pH gradients: Principle, methodology and some applicationsQ56032045
S100B is downregulated in the nuclear proteome of schizophrenia corpus callosumQ59791401
Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorderQ60440984
Identification of a biological signature for schizophrenia in serumQ60649874
Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patientsQ60649880
Approach to stationary two-dimensional pattern: influence of focusing time and immobiline/carrier ampholytes concentrationsQ69057084
SchizophreniaQ79226206
Impaired glucose tolerance in first-episode drug-naïve patients with schizophreniaQ80024902
Abnormal pathways in the genu of the corpus callosum in schizophrenia pathogenesis: a proteome studyQ82774054
Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestationQ84971446
Biomarkers in schizophreniaQ86928194
Talking back to madnessQ87437638
Insights into the regulation of protein abundance from proteomic and transcriptomic analysesQ36846022
Selected reaction monitoring for quantitative proteomics: a tutorialQ36973024
Proteomic analysis of eccrine sweat: implications for the discovery of schizophrenia biomarker proteinsQ36989604
Proteomic profiling in schizophrenia: enabling stratification for more effective treatmentQ36998471
A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathologyQ37235856
Redox dysregulation, neurodevelopment, and schizophreniaQ37501168
Proteome and transcriptome analysis suggests oligodendrocyte dysfunction in schizophreniaQ37584569
The audacity of proteomics: a chance to overcome current challenges in schizophrenia researchQ37636121
Proteome analysis of schizophrenia brain tissueQ37682924
The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomicsQ37776737
The neuroproteomics of schizophrenia.Q37796059
Sub-proteome approach to the knowledge of liverQ37817300
After GWAS: searching for genetic risk for schizophrenia and bipolar disorder.Q37834132
The genetic architecture of schizophrenia: new mutations and emerging paradigmsQ37950402
Proteomic technologies for biomarker studies in psychiatry: advances and needsQ37952388
Antipsychotics in the treatment of schizophrenia: an overviewQ37973145
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stressQ28257571
Difference gel electrophoresis: a single gel method for detecting changes in protein extractsQ28258266
Effectiveness of antipsychotic drugs in patients with chronic schizophreniaQ28273164
Genome-wide association analysis identifies 13 new risk loci for schizophreniaQ28297287
DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial traffickingQ28299770
A framework for interpreting genome-wide association studies of psychiatric disordersQ28300576
CSF metabolic and proteomic profiles in patients prodromal for psychosisQ28469277
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brainQ28507787
The role of genetics in the etiology of schizophreniaQ28748800
Cerebral organoids model human brain development and microcephalyQ28973619
Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagentsQ29547450
Mass-spectrometry-based draft of the human proteomeQ29617249
A draft map of the human proteomeQ29617250
Direct analysis of protein complexes using mass spectrometryQ29617450
Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophreniaQ30447546
Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patientsQ30468799
Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic modelsQ30476810
Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patientsQ30511886
Myelination, oligodendrocytes, and serious mental illnessQ30838265
Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collectionsQ30977897
Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression.Q33319373
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.Q33398247
Identification of subgroups of schizophrenia patients with changes in either immune or growth factor and hormonal pathwaysQ33762512
Differential proteomic analysis of mammalian tissues using SILAM.Q33809263
Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3.Q33887879
Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology ConsortiumQ33902752
Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomicsQ33920482
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophreniaQ33941953
Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disordersQ33945211
Genetic architectures of psychiatric disorders: the emerging picture and its implicationsQ33949729
Impaired metabolic reactivity to oxidative stress in early psychosis patientsQ34048645
A polygenic burden of rare disruptive mutations in schizophreniaQ34060200
Sex-specific proteome differences in the anterior cingulate cortex of schizophreniaQ34109438
Catching up on schizophrenia: natural history and neurobiologyQ34122141
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learnedQ34147518
The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophreniaQ34197032
Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trialsQ34205157
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degenerationQ34256510
Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directionsQ34279143
Analyzing schizophrenia by DNA microarraysQ34367499
Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophreniaQ34398952
Mass spectrometry in proteomicsQ34441839
Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteinsQ34473545
Oxidative stress in schizophrenia: An integrated approachQ34494844
RNA-Seq analysis implicates dysregulation of the immune system in schizophreniaQ34530641
De novo mutations in schizophrenia implicate synaptic networksQ34540372
The genetics of schizophrenia and bipolar disorder: dissecting psychosisQ34555635
The nature of systems biologyQ34582744
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysisQ34888915
Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.Q34911118
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophreniaQ34928687
Deciphering the human brain proteome: characterization of the anterior temporal lobe and corpus callosum as part of the Chromosome 15-centric Human Proteome ProjectQ35052619
Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorderQ35079675
Multiplatform metabolome and proteome profiling identifies serum metabolite and protein signatures as prospective biomarkers for schizophrenia.Q35162008
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.Q35216451
A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlasQ35264564
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Q35856391
Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia.Q36148572
Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophreniaQ36152879
Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic functionQ36377477
Critical appraisal of DNA microarrays in psychiatric genomics.Q36450259
Biochemical fractionation and stable isotope dilution liquid chromatography-mass spectrometry for targeted and microdomain-specific protein quantification in human postmortem brain tissueQ36455717
Interpreting the protein language using proteomics.Q36488705
DISC1 genetics, biology and psychiatric illnessQ36634401
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P921main subjectschizophreniaQ41112
P304page(s)14003
P577publication date2015-03-04
P1433published inNPJ schizophreniaQ27726482
P1476titleThe proteome of schizophrenia
P478volume1

Reverse relations

cites work (P2860)
Q36020336A reference library of peripheral blood mononuclear cells for SWATH-MS analysis
Q50054678Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients
Q47763221Combining Patient-Reprogrammed Neural Cells and Proteomics as a Model to Study Psychiatric Disorders.
Q90069138Computational chemoproteomics to understand the role of selected psychoactives in treating mental health indications
Q38869531Connecting Brain Proteomics with Behavioural Neuroscience in Translational Animal Models of Neuropsychiatric Disorders.
Q51298241Depletion of Highly Abundant Proteins of the Human Blood Plasma: Applications in Proteomics Studies of Psychiatric Disorders.
Q91942111Dystrophy of Oligodendrocytes and Adjacent Microglia in Prefrontal Gray Matter in Schizophrenia
Q30388470Effect of MK-801 and Clozapine on the Proteome of Cultured Human Oligodendrocytes
Q38985869Epigenetic Treatment of Persistent Viral Infections.
Q31049198Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases
Q46143080Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada
Q92188482Kininogen-1 as a protein biomarker for schizophrenia through mass spectrometry and genetic association analyses
Q26771434Making Sense of Blood-Based Proteomics and Metabolomics in Psychiatric Research
Q28078375Mass Spectrometry-Based Approaches to Understand the Molecular Basis of Memory
Q91619653Mitochondrial Dysfunction and Changes in High-Energy Compounds in Different Cellular Models Associated to Hypoxia: Implication to Schizophrenia
Q35880985Molecular Signatures of Psychosocial Stress and Cognition Are Modulated by Chronic Lithium Treatment
Q98205070Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders
Q52372478New considerations for hiPSC-based models of neuropsychiatric disorders.
Q89983282Post-translational protein modifications in schizophrenia
Q47763202Preparation of Peripheral Blood Mononuclear Cells (PBMCs) as a Model for Proteomic Studies of Psychiatric Disorders
Q26766821Proteomics Research in Schizophrenia
Q38903697Proteomics and molecular tools for unveiling missing links in the biochemical understanding of schizophrenia
Q57169146Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future
Q92070536Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
Q47688592Proteomics in the Diagnosis of Inborn Encephalopathies of Unknown Origin: A Myth or Reality
Q40671746Proteomics of the corpus callosum unravel pivotal players in the dysfunction of cell signaling, structure, and myelination in schizophrenia brains
Q91757366Salivary Flow Alteration in Patients Undergoing Treatment for Schizophrenia: Disease-Drug-Target Gene/Protein Association Study for Side-effects
Q34531777Schizophrenia interactome with 504 novel protein-protein interactions
Q48239735Selective Reaction Monitoring Mass Spectrometry for Quantitation of Glycolytic Enzymes in Postmortem Brain Samples.
Q41286620The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence
Q99238089The Gut Microbiome in Psychosis From Mice to Men: A Systematic Review of Preclinical and Clinical Studies
Q47844652The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains
Q60045096Ultrastructural pathology of oligodendrocytes adjacent to microglia in prefrontal white matter in schizophrenia

Search more.