Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells.

scientific article published on 27 March 2013

Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2012-10-461566
P932PMC publication ID3656449
P698PubMed publication ID23535064

P50authorPilar Martínez-ViedmaQ80421794
P2093author name stringSumeet Gupta
Nayoung Kim
Anna Aldovini
Sami Kukkonen
P2860cites workIRF7: activation, regulation, modification and functionQ24299740
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene clusterQ24313936
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathwayQ24650627
Mutational analysis of the conserved basic domain of human immunodeficiency virus tat proteinQ24656004
Mammalian MAP kinase signalling cascadesQ28204140
HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophagesQ28204428
Mechanisms of type-I- and type-II-interferon-mediated signallingQ28247893
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptorsQ28260114
Genetic variation in Toll-like receptors and disease susceptibilityQ28267031
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesQ29614338
Toll-like receptors and innate immunityQ29615458
Cell-type-specific proteome and interactome: using HIV-1 Tat as a test caseQ33347964
HIV-1 activates macrophages independent of Toll-like receptorsQ33388690
HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytesQ33455734
Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytesQ33604853
Association of Tat with Promoters of PTEN and PP2A Subunits Is Key to Transcriptional Activation of Apoptotic Pathways in HIV-Infected CD4+ T CellsQ33700607
TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFNQ33763210
A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrationsQ33998110
Chromatin immunoprecipitation and microarray-based analysis of protein locationQ34003310
p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylationQ34190231
Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infectionQ34346743
Activation and signaling of the p38 MAP kinase pathwayQ34390191
Transcription factor redundancy ensures induction of the antiviral stateQ34439072
MAP kinases in the immune responseQ34542231
New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).Q34919381
Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitisQ35083375
Regulation of JAK-STAT signalling in the immune systemQ35605437
Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammationQ35685580
Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.Q35804608
Human and simian immunodeficiency virus-mediated upregulation of the apoptotic factor TRAIL occurs in antigen-presenting cells from AIDS-susceptible but not from AIDS-resistant speciesQ35914497
Impact of Tat Genetic Variation on HIV-1 DiseaseQ36148507
Alternative and accessory pathways in the regulation of IFN-beta-mediated gene expressionQ36351976
Type I interferon during viral infections: multiple triggers for a multifunctional mediator.Q36985410
Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytesQ37150920
The multi-tasking P-TEFb complexQ37177846
Activation of host pattern recognition receptors by viruses.Q37764231
Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response.Q37781305
The control of HIV transcription: keeping RNA polymerase II on trackQ37958430
An overview of intracellular interactions between immunodeficiency viruses and their hostsQ37999622
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferonsQ38319422
Interferon gene expression following HIV type 1 infection of monocyte-derived macrophages.Q38333364
Differentiation of monocytes to macrophages primes cells for lipopolysaccharide stimulation via accumulation of cytoplasmic nuclear factor kappaB.Q39512511
Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli.Q39875310
Proinflammatory cytokines and HIV-1 synergistically enhance CXCL10 expression in human astrocytes.Q39921141
Role of STAT2 in the alpha interferon signaling pathwayQ40015757
Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling.Q40467468
Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line modelQ40964829
Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferonsQ45219850
Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation.Q48492843
The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteinsQ73947973
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)4090-4100
P577publication date2013-03-27
P1433published inBloodQ885070
P1476titleTat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells
P478volume121

Reverse relations

cites work (P2860)
Q38214994Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection
Q34364911Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3
Q41639946Effect of combination therapy of propofol and sevoflurane on MAP2K3 level and myocardial apoptosis induced by ischemia-reperfusion in rats
Q89659960Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells
Q36520900HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells
Q33678960HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells.
Q38856263Improving combination antiretroviral therapy by targeting HIV-1 gene transcription.
Q40097513Mechanism of Interferon Stimulated Gene Induction in HIV-1 Infected Macrophages
Q40683578MicroRNA-541 promotes the proliferation of vascular smooth muscle cells by targeting IRF7.
Q47245579Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain
Q90635181TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection
Q39130522Tat is a multifunctional viral protein that modulates cellular gene expression and functions
Q42207619The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin

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