HIV-1 reverse transcription: close encounters between the viral genome and a cellular tRNA.

scientific article published on January 2007

HIV-1 reverse transcription: close encounters between the viral genome and a cellular tRNA. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1054-3589(07)55003-9
P698PubMed publication ID17586313

P50authorBen BerkhoutQ29840155
Truus E M AbbinkQ92487230
P2860cites workIncorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1Q24529517
Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys)Q24675393
Preferences for the selection of unique tRNA primers revealed from analysis of HIV-1 replication in peripheral blood mononuclear cellsQ24791889
The connection domain in reverse transcriptase facilitates the in vivo annealing of tRNALys3 to HIV-1 genomic RNAQ24806162
Initiation of HIV-1 reverse transcription is regulated by a primer activation signalQ28198193
The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assemblyQ28205104
RNA interactions in the 5' region of the HIV-1 genomeQ28241918
Nucleotide sequence of the AIDS virus, LAVQ28286313
Role of Pr160gag-pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particlesQ28646824
Identification of tRNAs incorporated into wild-type and mutant human immunodeficiency virus type 1Q28646853
Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1Q28646885
Primer tRNAs for reverse transcriptionQ28775697
Compilation of tRNA sequences and sequences of tRNA genesQ29615891
The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogueQ30176747
Selection of functional tRNA primers and primer binding site sequences from a retroviral combinatorial library: identification of new functional tRNA primers in murine leukemia virus replicationQ30651852
Replication of avian sarcoma virus in vivo requires an interaction between the viral RNA and the TpsiC loop of the tRNA(Trp) primerQ31093710
Human immunodeficiency virus uses tRNA(Lys,3) as primer for reverse transcription in HeLa-CD4+ cellsQ45789971
Interactions with tRNALysinduce important structural changes in human immunodeficiency virus reverse transcriptaseQ45859998
Preferential interaction of human immunodeficiency virus reverse transcriptase with two regions of primer tRNA(Lys) as evidenced by footprinting studies and inhibition with synthetic oligoribonucleotidesQ45873081
Structural variability of the initiation complex of HIV-1 reverse transcription.Q47350836
Heteronuclear NMR studies of the interaction of tRNA3Lys with HIV-1 nucleocapsid protein11Edited by M. F. SummersQ57526892
In VitroCharacterization of the Interaction between HIV-1 Gag and Human Lysyl-tRNA SynthetaseQ58076318
Effects of tRNA3Lys aminoacylation on the initiation of HIV-1 reverse transcriptionQ61911604
Dynamics of the HIV-1 Reverse Transcription Complex during Initiation of DNA SynthesisQ61911616
Restoration of tRNA3Lys-primed(-)-strand DNA synthesis to an HIV-1 reverse transcriptase mutant with extended tRNAs. Implications for retroviral replicationQ71058744
HIV-1 reverse transcriptase discriminates against non-self tRNA primersQ71850775
Analysis of the Interactions of HIV1 Replication Primer tRNALys,3 with Nucleocapsid Protein and Reverse TranscriptaseQ72083397
Initiation of reverse transcription of HIV-1: secondary structure of the HIV-1 RNA/tRNA(3Lys) (template/primer)Q72134543
HIV-1 RNA editing, hypermutation, and error-prone reverse transcriptionQ73728115
Sequences within Pr160gag-pol affecting the selective packaging of primer tRNA(Lys3) into HIV-1Q73910219
Nucleotide sequences within the U5 region of the viral RNA genome are the major determinants for an human immunodeficiency virus type 1 to maintain a primer binding site complementary to tRNA(His).Q45765891
Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domainsQ45774047
The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding siteQ33647840
Few mutations in the 5' leader region mediate fitness recovery of debilitated human immunodeficiency type 1 virusesQ33755126
Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interactionQ33889660
Structural basis for the specificity of the initiation of HIV-1 reverse transcriptionQ33890456
Initiation of HIV-2 reverse transcription: a secondary structure model of the RNA-tRNA(Lys3) duplexQ33940170
Genome organization and transactivation of the human immunodeficiency virus type 2.Q34048704
Interaction of tryptophan tRNA and avian myeloblastosis virus reverse transcriptase: further characterization of the binding reactionQ34276169
Effect of altering the tRNA(Lys)(3) concentration in human immunodeficiency virus type 1 upon its annealing to viral RNA, GagPol incorporation, and viral infectivityQ34344599
Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAsQ34353288
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.Q34382153
Forced evolution of a regulatory RNA helix in the HIV-1 genomeQ34626639
The primer binding site on the RNA genome of human and simian immunodeficiency viruses is flanked by an upstream hairpin structureQ34639614
Mutational analysis of the tRNA3Lys/HIV-1 RNA (primer/template) complex.Q34658242
The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcriptionQ34969808
Retrovirus-mediated insertion of expressed and non-expressed genes at identical chromosomal locationsQ34983618
Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assemblyQ35123403
Effect of polymerase mutations on packaging of primer tRNAPro during murine leukemia virus assemblyQ35237462
The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in repQ35794241
Human immunodeficiency virus type 1 can use different tRNAs as primers for reverse transcription but selectively maintains a primer binding site complementary to tRNA(3Lys)Q35847385
Primer tRNA3Lys on the viral genome exists in unextended and two-base extended forms within mature human immunodeficiency virus type 1.Q35875824
Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanismQ36258296
Reverse transcriptase as the major determinant for selective packaging of tRNA's into Avian sarcoma virus particlesQ36508415
Small RNAs of Rous sarcoma virus: characterization by two-dimensional polyacrylamide gel electrophoresis and fingerprint analysisQ36596117
Incorporation of excess wild-type and mutant tRNA(3Lys) into human immunodeficiency virus type 1.Q36637578
Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcriptionQ36701633
Isolation of a recombinant murine leukemia virus utilizing a new primer tRNA.Q36855313
A retroviral RNA secondary structure required for efficient initiation of reverse transcriptionQ36872904
Recombination between a defective retrovirus and homologous sequences in host DNA: reversion by patch repairQ36898930
Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingersQ37111477
Reverse transcriptase of human immunodeficiency virus can use either human tRNA(3Lys) or Escherichia coli tRNA(2Gln) as a primer in an in vitro primer-utilization assayQ37248161
Initiation of (-) strand DNA synthesis from tRNA(3Lys) on lentiviral RNAs: implications of specific HIV-1 RNA-tRNA(3Lys) interactions inhibiting primer utilization by retroviral reverse transcriptases.Q37324137
Synthetic tRNALys,3 as the replication primer for the HIV-1HXB2 and HIV-1Mal genomesQ37509321
Site-specific crosslinking of 4-thiouridine-modified human tRNA(3Lys) to reverse transcriptase from human immunodeficiency virus type I.Q37698214
Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: a quantitative in vivo assay for function of initiation complexes.Q37730594
Structural requirements for the binding of tRNA Lys3 to reverse transcriptase of the human immunodeficiency virus type 1.Q38290548
An expanded model of replicating human immunodeficiency virus reverse transcriptaseQ38296396
Studies on primer binding of HIV-1 reverse transcriptase using a fluorescent probeQ38311025
Mutated primer binding sites interacting with different tRNAs allow efficient murine leukemia virus replicationQ38314018
A structured RNA motif is involved in correct placement of the tRNA(3)(Lys) primer onto the human immunodeficiency virus genomeQ38315663
Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcriptionQ38328581
Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer bindingQ38332453
Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcriptionQ38334633
Interaction of HIV-1 reverse transcriptase with a synthetic form of its replication primer, tRNALys,3Q38336483
Stability of HIV type 1 proviral genomes that contain two distinct primer-binding sitesQ38348466
On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genomeQ38351251
Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcriptionQ38354024
Molecular analysis of the second template switch during reverse transcription of the HIV RNA templateQ38354136
Does the HIV-1 primer activation signal interact with tRNA3(Lys) during the initiation of reverse transcription?Q38358122
Efficient initiation of HIV-1 reverse transcription in vitro. Requirement for RNA sequences downstream of the primer binding site abrogated by nucleocapsid protein-dependent primer-template interactionsQ38358135
Transfer RNA into RNA tumor virusesQ39456157
Roles of Pr55(gag) and NCp7 in tRNA(3)(Lys) genomic placement and the initiation step of reverse transcription in human immunodeficiency virus type 1.Q39585566
Stabilization of the U5-leader stem in the HIV-1 RNA genome affects initiation and elongation of reverse transcriptionQ39597535
Probing the importance of tRNA anticodon: human immunodeficiency virus type 1 (HIV-1) RNA genome complementarity with an HIV-1 that selects tRNA(Glu) for replicationQ39796706
Forced selection of a human immunodeficiency virus type 1 variant that uses a non-self tRNA primer for reverse transcription: involvement of viral RNA sequences and the reverse transcriptase enzymeQ39991696
Specific inhibition of the synthesis of human lysyl-tRNA synthetase results in decreases in tRNA(Lys) incorporation, tRNA(3)(Lys) annealing to viral RNA, and viral infectivity in human immunodeficiency virus type 1.Q39996496
The G490E mutation in reverse transcriptase does not impact tRNA primer selection by HIV-1 with altered PBS and A-loopQ40266291
Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1.Q40284337
tRNAs as primer of reverse transcriptasesQ40402097
Alternative tRNA priming of human immunodeficiency virus type 1 reverse transcription explains sequence variation in the primer-binding site that has been attributed to APOBEC3G activityQ40458904
Ability of wild-type and mutant lysyl-tRNA synthetase to facilitate tRNA(Lys) incorporation into human immunodeficiency virus type 1.Q40468614
Improved envelope function selected by long-term cultivation of a translation-impaired HIV-1 mutantQ41040160
Insights into the interaction between tRNA and primer binding site from characterization of a unique HIV-1 virus which stably maintains dual PBS complementary to tRNA(Gly) and tRNA(His).Q41076573
Functional differences between the human LINE retrotransposon and retroviral reverse transcriptases for in vivo mRNA reverse transcriptionQ41082589
Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcriptionQ41191459
HIV-1 Reverse Transcription A Termination Step at the Center of the GenomeQ41443092
DNA found in human immunodeficiency virus type 1 particles may not be required for infectivityQ41459906
Variable tRNA content in HIV-1IIIB.Q41618219
Mutations in the central polypurine tract of HIV-1 result in delayed replicationQ42021373
Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS.Q42107901
Defective replication in human immunodeficiency virus type 1 when non-primers are used for reverse transcription.Q42589496
A novel long distance base-pairing interaction in human immunodeficiency virus type 1 RNA occludes the Gag start codonQ42689207
The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation.Q42764292
Cross-linking localization of a HIV-1 reverse transcriptase peptide involved in the binding of primer tRNALys3.Q43722479
HIV-1 nucleocapsid protein zinc finger structures induce tRNA(Lys,3) structural changes but are not critical for primer/template annealingQ44253743
Correlation between tRNALys3 aminoacylation and its incorporation into HIV-1.Q44702647
Identification of a human immunodeficiency virus type 1 that stably uses tRNALys1,2 rather than tRNALys,3 for initiation of reverse transcriptionQ45749973
Sequence elements downstream of the human immunodeficiency virus type 1 long terminal repeat are required for efficient viral gene transcriptionQ45760530
Sequence variation of the human immunodeficiency virus primer-binding site suggests the use of an alternative tRNA(Lys) molecule in reverse transcriptionQ45763410
P304page(s)99-135
P577publication date2007-01-01
P1433published inAdvances in PharmacologyQ15753809
P1476titleHIV-1 reverse transcription: close encounters between the viral genome and a cellular tRNA.
P478volume55