Over expression of hyaluronan promotes progression of HCC via CD44-mediated pyruvate kinase M2 nuclear translocation

scientific article published on 15 January 2016

Over expression of hyaluronan promotes progression of HCC via CD44-mediated pyruvate kinase M2 nuclear translocation is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID4859677
P698PubMed publication ID27186420

P2093author name stringYan Wang
Lan Zhang
Rui Zhang
Yan-Hong Wang
Jing-Huan Li
Rong-Rong Yao
Zheng-Gang Ren
Xiao-Ying Xie
Cheng-Dong Qin
Ying-Cong Wang
P2860cites workHyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1)Q24294210
Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell InvasionQ24608189
Global cancer statistics, 2012Q27860501
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinomaQ29616287
The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor GenesQ29619577
4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expressionQ34346660
Mechanical Stretch Induces Epithelial-Mesenchymal Transition in Alveolar Epithelia via Hyaluronan Activation of Innate ImmunityQ34978863
CD44 variant 6 is associated with prostate cancer metastasis and chemo-/radioresistanceQ35116847
Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1Q36111609
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cellsQ36116059
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effectQ36437994
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancerQ36550798
Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signalsQ36890696
Role of Hyaluronan-Mediated CD44 Signaling in Head and Neck Squamous Cell Carcinoma Progression and ChemoresistanceQ37847694
Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.Q38052531
Extracellular matrix components in breast cancer progression and metastasisQ38145838
Metabolic control of hyaluronan synthases.Q38153502
Hyaluronan: towards novel anti-cancer therapeuticsQ38176587
Hyaluronan: biosynthesis and signaling.Q38186894
The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistanceQ38216639
Modulation of hyaluronan production by CD44 positive glioma cellsQ38405896
Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cellsQ38558752
Role of hyaluronan synthase 2 to promote CD44‐dependent oral cavity squamous cell carcinoma progressionQ39369826
Overexpression of Hyaluronan-binding Protein 1 (HABP1/p32/gC1qR) in HepG2 Cells Leads to Increased Hyaluronan Synthesis and Cell Proliferation by Up-regulation of Cyclin D1 in AKT-dependent PathwayQ39373283
Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.Q39403553
Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice.Q39450694
Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cellsQ39723976
Differential activation of ERK and Rac mediates the proliferative and anti-proliferative effects of hyaluronan and CD44.Q41895263
Transient elastography for the detection of hepatocellular carcinoma in viral C liver cirrhosis. Is there something else than increased liver stiffness?Q42265812
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressureQ42655521
Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis.Q54611728
Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarrayQ73083120
P433issue2
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)509-521
P577publication date2016-01-15
P1433published inAmerican Journal of Cancer ResearchQ17511667
P1476titleOver expression of hyaluronan promotes progression of HCC via CD44-mediated pyruvate kinase M2 nuclear translocation
P478volume6

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cites work (P2860)
Q58554489Activated hepatic stellate cells promote epithelial-to-mesenchymal transition in hepatocellular carcinoma through transglutaminase 2-induced pseudohypoxia
Q64109809Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis
Q53177828Inhibition of Systemic Hyaluronan Synthesis Exacerbates Murine Hepatic Carcinogenesis
Q64052630PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma

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