Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells

scientific article published on 20 June 2011

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1047181286
P356DOI10.1038/ONC.2011.222
P932PMC publication ID3179812
P698PubMed publication ID21685938
P5875ResearchGate publication ID51231383

P2093author name stringG Wong
K Krueger
C Earle
C C Spevak
L Y W Bourguignon
P2860cites workRegulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.Q37500527
Role of Hyaluronan-Mediated CD44 Signaling in Head and Neck Squamous Cell Carcinoma Progression and ChemoresistanceQ37847694
Establishment and characterization of a cisplatin-resistant oral squamous cell carcinoma cell line, H-1R.Q38320162
Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinomaQ39966384
Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancerQ40134000
Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinomaQ40361266
Hyaluronan and tumor growthQ42794422
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancerQ24292870
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cellsQ24319922
Principles of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
A microRNA expression signature of human solid tumors defines cancer gene targetsQ24541455
Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell InvasionQ24608189
CD44 variant isoforms in head and neck squamous cell carcinoma progressionQ24642719
Global cancer statistics, 2002Q27860562
Cancer statistics, 2008Q27860585
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cellsQ28176663
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
STATs and Gene RegulationQ29547796
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancerQ29616316
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signalingQ33867608
STAT signaling in head and neck cancerQ33941351
Signaling Properties of Hyaluronan ReceptorsQ34444928
Hyaluronan-Cell Interactions in Cancer and Vascular DiseaseQ34444933
MicroRNA alterations in head and neck squamous cell carcinoma.Q35253630
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cellsQ36719279
Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implicationsQ36749049
The inhibitors of apoptosis (IAPs) as cancer targetsQ36851057
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progressionQ37152303
SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.Q37445045
Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotheraQ37446718
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
head and neck squamous cell carcinomaQ18348812
P304page(s)149-160
P577publication date2011-06-20
P1433published inOncogeneQ1568657
P1476titleStem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells
P478volume31

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