Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling

scientific article published on 15 June 2017

Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1086033390
P356DOI10.1038/CDDIS.2017.248
P932PMC publication ID5520906
P698PubMed publication ID28617438

P50authorNingbo XuQ57571770
P2093author name stringZhao Yang
Boyang Liu
Hongbo Guo
Changlin Lian
Huijun Zeng
Zhao Fu
P2860cites workCTGF is overexpressed in papillary thyroid carcinoma and promotes the growth of papillary thyroid cancer cellsQ54377230
Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM ModelQ38739262
Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibitionQ38759750
Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathwayQ38846848
Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cellsQ38849643
Targeting cancer stem cell-specific markers and/or associated signaling pathways for overcoming cancer drug resistanceQ38937280
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.Q38955683
Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapyQ39017301
CTGF increases drug resistance to paclitaxel by upregulating survivin expression in human osteosarcoma cellsQ39030787
TGF-β: an emerging player in drug resistanceQ39105549
Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.Q39224420
CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration.Q39524486
Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacityQ39680687
Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1.Q39863143
Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell linesQ40252973
Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinaseQ42479992
Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomasQ44418604
Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signalingQ45852778
Proposal for a unified CCN nomenclatureQ24535512
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Cancer stem cell metabolism: a potential target for cancer therapyQ28079045
Signal transduction by the TGF-beta superfamilyQ28201963
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancerQ29616360
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating featuresQ29620020
Non-Smad pathways in TGF-beta signalingQ29620040
The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cellsQ30440228
Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiformeQ34158700
Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling.Q34217241
Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathwayQ34410089
miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomasQ34423084
Chemoresistance of glioblastoma cancer stem cells - much more complex than expectedQ35521316
Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factorsQ35545648
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinomaQ35871985
O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomasQ36288503
Mechanisms of chemoresistance to alkylating agents in malignant gliomaQ36726010
Cancer stem cells and chemoresistance: The smartest survives the raidQ36730432
The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrenceQ36795940
Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cellsQ36942777
CCN2, the connective tissue growth factorQ37031962
Connective tissue growth factor (CTGF) and cancer progressionQ37214721
Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activationQ37234131
Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell linesQ37536715
Current concepts and management of glioblastomaQ37904921
Deregulated expression of connective tissue growth factor (CTGF/CCN2) is linked to poor outcome in human cancerQ38212057
Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditionsQ38258015
Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells.Q38315365
Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cellsQ38558752
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue6
P921main subjectconnective tissueQ25615
glioblastomaQ282142
P304page(s)e2885
P577publication date2017-06-15
P1433published inCell Death and DiseaseQ2197222
P1476titleConnective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling
P478volume8

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cites work (P2860)
Q57788828Apatinib suppresses cell growth and metastasis and promotes antitumor activity of temozolomide in glioma
Q91251189CTGF regulates cyclic stretch-induced vascular smooth muscle cell proliferation via microRNA-19b-3p
Q64068632Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
Q92237966Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools
Q90515465Connective tissue growth factor as an unfavorable prognostic marker promotes the proliferation, migration, and invasion of gliomas
Q65000057ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer.
Q58797237Glycogenolysis in Acquired Glioma Resistance to Temozolomide: A Role for the [Ca]-dependent Activation of Na,K-ATPase/ERK Signaling
Q59136674Long noncoding RNA AC003092.1 promotes temozolomide chemosensitivity through miR-195/TFPI-2 signaling modulation in glioblastoma
Q59335925OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth
Q57816901The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
Q91791041The TGFβ1-FOXM1-HMGA1-TGFβ1 positive feedback loop increases the cisplatin resistance of non-small cell lung cancer by inducing G6PD expression
Q92592813YAP/TAZ Signaling and Resistance to Cancer Therapy

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