The TGFβ1-FOXM1-HMGA1-TGFβ1 positive feedback loop increases the cisplatin resistance of non-small cell lung cancer by inducing G6PD expression

scientific article published on 15 November 2019

The TGFβ1-FOXM1-HMGA1-TGFβ1 positive feedback loop increases the cisplatin resistance of non-small cell lung cancer by inducing G6PD expression is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID6895501
P698PubMed publication ID31814893

P50authorZejun FangQ50084464
P2093author name stringRongwei Zhang
Yanyan Hu
Chaoju Gong
Fuzheng Tao
Lingming Mei
Miaoxian Hu
Shenghui Ruan
P2860cites workFOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistanceQ26864654
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Glucose-6-phosphate dehydrogenase, NADPH, and cell survivalQ35886019
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistanceQ36165185
Phospho-ΔNp63α/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistanceQ36392145
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Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer.Q37698720
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Simvastatin attenuates macrophage-mediated gemcitabine resistance of pancreatic ductal adenocarcinoma by regulating the TGF-β1/Gfi-1 axisQ38731433
FOXM1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and mediates sensitivity to cisplatin in A549 cells via the JNK/mitochondrial pathwayQ38922674
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Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activityQ39523446
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligaseQ40700999
The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cellsQ40996773
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder CancerQ41481557
ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathwayQ46255272
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TGFβ1 synergizes with FLT3 ligand to induce chemoresistant quiescence in acute lymphoblastic leukemia with MLL gene rearrangementsQ47792704
Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox SystemQ49441931
TGFβ pathway inhibition in the treatment of non-small cell lung cancerQ50054712
NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signalingQ50084400
FASN-TGF-β1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cellsQ50152457
Cancer-associated fibroblasts mediated chemoresistance by a FOXO1/TGFβ1 signaling loop in esophageal squamous cell carcinoma.Q51370517
FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway.Q51573165
ATR-CHK1-E2F3 signaling transactivates human ribonucleotide reductase small subunit M2 for DNA repair induced by the chemical carcinogen MNNG.Q54211934
Targeting Forkhead Box M1 Transcription Factor in Breast Cancer.Q54977309
Involvement of FoxM1 in non-small cell lung cancer recurrenceQ85492085
Elevated expression of HMGA1 correlates with the malignant status and prognosis of non-small cell lung cancerQ85853672
Recent clinical advances in lung cancer managementQ87355242
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cellsQ90277883
The long noncoding RNA HIF1A-AS2 facilitates cisplatin resistance in bladder cancerQ91449607
P433issue11
P921main subjectcisplatinQ412415
non-small-cell lung carcinomaQ3658562
P304page(s)6860-6876
P577publication date2019-11-15
P1433published inAmerican Journal of Translational ResearchQ4744272
P1476titleThe TGFβ1-FOXM1-HMGA1-TGFβ1 positive feedback loop increases the cisplatin resistance of non-small cell lung cancer by inducing G6PD expression
P478volume11

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Q89550697The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistancecites workP2860

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