HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer

HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/CMAR.S188364
P932PMC publication ID6296682
P698PubMed publication ID30588091

P2093author name stringHaiyong Wang
Lisong Teng
Mengjie Wu
Haohao Wang
Zhongqi Li
Zhenzhen Xu
Xiongfei Yu
Xiaoxia Jiang
P2860cites workDual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal CancersQ26781362
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Stat3 as an oncogeneQ29614606
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WEGO: a web tool for plotting GO annotationsQ29616658
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptorsQ33941380
STAT-3 correlates with lymph node metastasis and cell survival in gastric cancerQ34306802
The MAPK pathway across different malignancies: a new perspectiveQ34459097
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic interventionQ34595904
STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.Q53594652
Suppression of cancer relapse and metastasis by inhibiting cancer stemnessQ35090120
Strategies and Approaches of Targeting STAT3 for Cancer Treatment.Q35884979
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signalingQ36006981
The challenge of targeting metastasisQ36322825
KEGG as a reference resource for gene and protein annotationQ36434599
Discovery of O-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer AgentsQ36641981
Constitutive activation of STAT3 in breast cancer cells: A reviewQ36711689
Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implicationsQ36749049
Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma.Q37345331
STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancerQ37491122
Pathological roles of MAPK signaling pathways in human diseasesQ37676393
Targeting MAPK pathway in melanoma therapyQ38098888
A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancerQ38170840
Compromised MAPK signaling in human diseases: an updateQ38359194
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cellsQ38360859
c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Q38492604
A Comprehensive Structural Overview of p38α MAPK in Complex with Type I InhibitorsQ38503202
Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cellsQ38558752
The prognostic value of pSTAT3 in gastric cancer: a meta-analysisQ38559001
Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152.Q38718723
Targeting metastasisQ38786658
Cancer treatment and survivorship statistics, 2016.Q38859236
Cancer Statistics, 2017.Q39038674
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancerQ39587868
Cancer statistics in China, 2015.Q40064386
Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line.Q40064435
Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model.Q41634189
Role of MAPKs in platinum-induced neuronal apoptosis.Q46018598
FH535 Inhibits Proliferation and Motility of Colon Cancer Cells by Targeting Wnt/β-catenin Signaling PathwayQ47135534
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P1104number of pages11
P304page(s)6857-6867
P577publication date2018-01-01
P1433published inCancer Management and ResearchQ5031417
P1476titleHJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer
P478volume10

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cites work (P2860)
Q64087577A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma
Q92094288Dysregulated miRNA in a cancer-prone environment: A study of gastric non-neoplastic mucosa
Q89542508HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism
Q92626717Upregulation of family with sequence similarity 83 member D expression enhances cell proliferation and motility via activation of Wnt/β-catenin signaling and predicts poor prognosis in gastric cancer

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