Suppression of cancer relapse and metastasis by inhibiting cancer stemness

scientific article

Suppression of cancer relapse and metastasis by inhibiting cancer stemness is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112.1839L
P356DOI10.1073/PNAS.1424171112
P932PMC publication ID4330785
P698PubMed publication ID25605917
P5875ResearchGate publication ID273352737

P2093author name stringWei Li
Yuan Gao
Keith Mikule
Arthur B Pardee
Youzhi Li
David Leggett
Sarah Keates
Chiang J Li
Harry A Rogoff
Sylaja Murikipudi
P2860cites workDrug Resistance: Challenges to Effective TherapyQ37864345
The developing cancer stem-cell model: clinical challenges and opportunitiesQ37980960
Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer.Q38023942
Emerging insights into resistance to BRAF inhibitors in melanomaQ38167587
Revisiting STAT3 signalling in cancer: new and unexpected biological functionsQ38262473
CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG RegulationQ39512947
Targeting of CD44 eradicates human acute myeloid leukemic stem cellsQ40228130
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesisQ42972239
TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cellsQ45077632
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasisQ24307454
Phenotypic characterization of human colorectal cancer stem cellsQ24674126
Prospective identification of tumorigenic breast cancer cellsQ24683474
Cancer stem cells--important players in tumor therapy resistanceQ26823015
Concise Review: The Sox2-Oct4 Connection: Critical Players in a Much Larger Interdependent Network Integrated at Multiple LevelsQ27001663
A human colon cancer cell capable of initiating tumour growth in immunodeficient miceQ27860831
Stem cells, cancer, and cancer stem cellsQ27860878
Identification of human brain tumour initiating cellsQ27860921
A cell initiating human acute myeloid leukaemia after transplantation into SCID miceQ28131777
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cellsQ28250509
Identification and expansion of the tumorigenic lung cancer stem cell populationQ28259332
Identification of pancreatic cancer stem cellsQ28286997
Cancer stem cells in solid tumours: accumulating evidence and unresolved questionsQ28293535
Model of tumor dormancy/recurrence after short-term chemotherapyQ28539003
Stat3 as an oncogeneQ29614606
Cancer drug resistance: an evolving paradigmQ29616694
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapyQ29617584
Tumour stem cells and drug resistanceQ29617742
Tumour heterogeneity and cancer cell plasticityQ29617990
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cellsQ29617991
Wnt activity defines colon cancer stem cells and is regulated by the microenvironmentQ29618024
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinomaQ29620604
A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemiaQ33182313
ALDH Activity Selectively Defines an Enhanced Tumor-Initiating Cell Population Relative to CD133 Expression in Human Pancreatic AdenocarcinomaQ33939548
The role of STATs in transcriptional control and their impact on cellular functionQ33941346
Nonadhesive Culture System as a Model of Rapid Sphere Formation with Cancer Stem Cell PropertiesQ34168436
Induction of cancer cell stemness by chemotherapyQ34316857
Ionizing radiation induces stemness in cancer cellsQ34395869
Transcription factors as targets for cancer therapyQ34932264
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumorsQ35572396
Concise Review: Pursuing Self-Renewal and Pluripotency with the Stem Cell Factor NanogQ36997249
Module map of stem cell genes guides creation of epithelial cancer stem cellsQ37067205
Cancer stem cell and cancer stemloids: from biology to therapyQ37111467
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway.Q37151086
Cancer stem cells and tumor response to therapy: current problems and future prospectsQ37403290
Treatment resistance in stem cells and breast cancerQ37406059
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1839-1844
P577publication date2015-01-20
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSuppression of cancer relapse and metastasis by inhibiting cancer stemness
P478volume112

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cites work (P2860)
Q618020202-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells
Q64244208A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness
Q64908014A Phase I Study of Napabucasin Plus Paclitaxel for Japanese Patients With Advanced/Recurrent Gastric Cancer.
Q41691950A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer
Q90259957A framework for the development of effective anti-metastatic agents
Q93054756A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells
Q90310096A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3-PBX1 and β-catenin-ABCG2 signaling
Q92787908A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells
Q102063580A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors
Q37684647Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity
Q26744536Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal
Q38971795Approaches for targeting cancer stem cells drug resistance
Q64269621BP‑1‑102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways
Q49189846Beyond Alkylating Agents for Gliomas: Quo Vadimus?
Q89965741Bidirectional Crosstalk Between Cancer Stem Cells and Immune Cell Subsets
Q90131783Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death
Q38511172Bioregulation
Q91999244CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling
Q26770274Cancer Stem Cell Plasticity Drives Therapeutic Resistance
Q50027179Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases
Q46088698Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.
Q38647014Cancer stem cell research in Iran: potentials and challenges.
Q38950219Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistance
Q86838788Cancer stem cells: Targeting the root of cancer relapse
Q47158074Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis.
Q39038994Challenges in molecular targeted therapy for gastric cancer: considerations for efficacy and safety
Q38815071Chemotherapy for advanced gastric cancer: future perspective in Japan
Q45067426Classifying the evolutionary and ecological features of neoplasms
Q33922534Clinical impact of tumour biology in the management of gastroesophageal cancer
Q44731136Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers
Q39112034Concise Review: Emerging Drugs Targeting Epithelial Cancer Stem-Like Cells
Q28081553Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation
Q57455148Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
Q60929057DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells
Q93204682DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression
Q64947408Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis.
Q89857370Differential sequences and single nucleotide polymorphism of exosomal SOX2 DNA in cancer
Q37639772Drug-Loaded Polymeric Nanoparticles for Cancer Stem Cell Targeting
Q58577525Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells
Q37652650Effects of U0126 and MK2206 on cell growth and re-growth of endometriotic stromal cells grown on substrates of varying stiffness
Q37129279Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer
Q55515412Emerging Therapies and Future Directions in Targeting the Tumor Stroma and Immune System in the Treatment of Pancreatic Adenocarcinoma.
Q57111080Emerging Therapies in the Management of Advanced-Stage Gastric Cancer
Q132042456Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
Q92282534Endoplasmic Reticulum Stress Pathway, the Unfolded Protein Response, Modulates Immune Function in the Tumor Microenvironment to Impact Tumor Progression and Therapeutic Response
Q60931354Engineered Models of Tumor Dormancy and Reactivation
Q87179773Epithelial-mesenchymal transition: a new target in anticancer drug discovery
Q26801710Evolutionary determinants of cancer
Q92156808Fibronectin in Cancer: Friend or Foe
Q36241043Functional significance of CD105-positive cells in papillary renal cell carcinoma.
Q38717511Generation of an inducible mouse model to reversibly silence Stat3.
Q91276909Gjb4 serves as a novel biomarker for lung cancer and promotes metastasis and chemoresistance via Src activation
Q64914568Glucosamine decreases the stemness of human ALDH+ breast cancer stem cells by inactivating STAT3.
Q47282038HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis.
Q60302891HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer
Q32177089Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples
Q37708991Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase
Q36165598Heterogeneity of Cancer Stem Cells: Rationale for Targeting the Stem Cell Niche
Q93018164Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane
Q47100629Hyperhomocysteinemia, Suppressed Immunity, and Altered Oxidative Metabolism Caused by Pathogenic Microbes in Atherosclerosis and Dementia
Q92551740IL-11 drives postsurgical hepatocellular carcinoma recurrence
Q36502358Identification of metastasis-associated genes in colorectal cancer using metaDE and survival analysis
Q30238811Identifying and targeting cancer stem cells in the treatment of gastric cancer
Q93190592If You Cannot Win Them, Join Them: Understanding New Ways to Target STAT3 by Small Molecules
Q52616966Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells
Q49849111In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: Autophagy may be required for regrowth of endometriosis.
Q60913777Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception
Q57028266Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
Q94460537LncRNA WT1-AS over-expression inhibits non-small cell lung cancer cell stemness by down-regulating TGF-β1
Q40975462Loss of Endometrial Plasticity in Recurrent Pregnancy Loss.
Q90266844MTA3-SOX2 Module Regulates Cancer Stemness and Contributes to Clinical Outcomes of Tongue Carcinoma
Q57112976Mammary Stem Cells and Breast Cancer Stem Cells: Molecular Connections and Clinical Implications
Q64061518Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells
Q28076041Molecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer
Q36354866Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity
Q94561568Napabucasin (BBI 608), a potent chemoradiosensitizer in rectal cancer
Q49351167Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial
Q91660543Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells
Q38675856Napabucasin: An Update on the First-in-Class Cancer Stemness Inhibitor
Q33734466Natural and synthetic progestins enrich cancer stem cell-like cells in hormone-responsive human breast cancer cell populations in vitro
Q38759129New agents on the horizon in gastric cancer
Q48943023New orally active DNA minor groove binding small molecule CT-1 acts against breast cancer by targeting tumor DNA damage leading to p53-dependent apoptosis
Q64951391Next Viable Routes to Targeting Pancreatic Cancer Stemness: Learning from Clinical Setbacks.
Q64990976Next-generation sequencing and biomarkers for gastric cancer: what is the future?
Q132047915Novel Anti-Cancer Stem Cell Compounds: A Comprehensive Review
Q38870465Novel STAT 3 inhibitors for treating gastric cancer
Q37688017Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells
Q53750080Novel pharmaceutical treatment approaches for gastric cancer
Q38794338Novel therapeutics in metastatic colorectal cancer: molecular insights and pharmacogenomic implications
Q91785141Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression
Q33902576Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling
Q48156973Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles.
Q36998357Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling
Q39406329Overview of Cancer Stem Cells and Stemness for Community Oncologists
Q92705174Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma
Q38682533Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells
Q99551134Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
Q38656908Pharmacotherapeutic treatment of germ cell tumors: standard of care and recent developments.
Q39039925Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer
Q39424549Prostate Cancer Stem Cell Markers Drive Progression, Therapeutic Resistance, and Bone Metastasis
Q92445524Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells
Q38633691Repurposing itraconazole as an anticancer agent
Q39190733Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme
Q92154668STAT3 Activation and Oncogenesis in Lymphoma
Q90400267STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
Q58778783STAT3 activation confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive breast cancer
Q39145689STAT3 activation in infection and infection-associated cancer
Q42324012STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter
Q90751298STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers
Q91211189STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells
Q89537609Self-Renewal Signalling Pathway Inhibitors: Perspectives on Therapeutic Approaches for Cancer Stem Cells
Q38747573Signaling pathways as therapeutic targets in biliary tract cancer.
Q64114562Single‑cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer
Q40971187Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells
Q50063665Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference
Q38792113Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin
Q55015991Targeted Therapies for Pancreatic Cancer.
Q64249982Targeted Therapies in Cholangiocarcinoma: Emerging Evidence from Clinical Trials
Q60956875Targeting Cancer Stem Cells to Overcome Chemoresistance
Q64885776Targeting Cancer Stem Cells: A Strategy for Effective Eradication of Cancer.
Q89776510Targeting DNA binding proteins for cancer therapy
Q49167162Targeting Pancreatic Cancer Cell Plasticity: The Latest in Therapeutics
Q92512238Targeting cancer stem cells in drug discovery: Current state and future perspectives
Q57805012Targeting colon cancer with the novel STAT3 inhibitor bruceantinol
Q100750176Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer
Q92652651Targeting the Interplay Between Cancer Fibroblasts, Mesenchymal Stem Cells, and Cancer Stem Cells in Desmoplastic Cancers
Q38600094Targeting the Wnt signaling pathway in colorectal cancer
Q64099576The Cancer Stem Cell Inhibitor Napabucasin (BBI608) Shows General Cytotoxicity in Biliary Tract Cancer Cells and Reduces Cancer Stem Cell Characteristics
Q38645695The Implications and Future Perspectives of Nanomedicine for Cancer Stem Cell Targeted Therapies.
Q97074390The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
Q92421507The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042
Q38691017The Use of Endometrial Cancer Patient-Derived Organoid Culture for Drug Sensitivity Testing Is Feasible
Q92980181The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis
Q38691172The immune system and cancer evasion strategies: therapeutic concepts
Q64110601Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies
Q26778983Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
Q90712078Therapeutically exploiting STAT3 activity in cancer - using tissue repair as a road map
Q64260465Transcriptional Reprogramming and Novel Therapeutic Approaches for Targeting Prostate Cancer Stem Cells
Q99212125Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I
Q88748954Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer
Q38824383Tumor-Initiating Cells: Emerging Biophysical Methods of Isolation
Q37649057Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies.
Q58787017Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells
Q91587954Wnt/β-Catenin Signaling in Liver Cancers
Q41281151YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells

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