STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells

scientific article published on 29 August 2018

STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41388-018-0449-Z
P698PubMed publication ID30158673

P2093author name stringGeorge Miller
N Joseph Espat
Steven C Katz
Prajna Guha
Richard P Junghans
Matthew Lima
Marissa Cunetta
Jillian Gardell
Josephine Darpolor
P2860cites workBcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell deathQ24312211
p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expressionQ28115373
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
IL-23 promotes tumour incidence and growthQ28239522
Apoptosis: a review of programmed cell deathQ28305845
Stat3 mediates myeloid cell-dependent tumor angiogenesis in miceQ28385532
Bax suppresses tumorigenesis and stimulates apoptosis in vivoQ28506493
The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cellsQ28592278
The STATs of cancer--new molecular targets come of ageQ29614601
Stattic: a small-molecule inhibitor of STAT3 activation and dimerizationQ33264035
Tumor MHC class I expression improves the prognostic value of T-cell density in resected colorectal liver metastases.Q33724135
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumorQ33805313
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathwaysQ33888307
The role of interleukin-2 during homeostasis and activation of the immune systemQ34255232
Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathwayQ34314210
Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects.Q34473451
Stat proteins and oncogenesisQ34627064
GM-CSF in inflammation and autoimmunity.Q34754737
Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell–expressed FasLQ35029951
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosisQ35035620
Suppression of cancer relapse and metastasis by inhibiting cancer stemnessQ35090120
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cellsQ35134007
NF-κB and STAT3 – key players in liver inflammation and cancerQ35347976
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progressionQ35478848
Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-TQ35798161
Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells.Q35799094
Fas/FasL interaction: a novel immune therapy approach with immobilized biologicalsQ35984883
Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cellsQ35987390
Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling.Q36302820
Transcriptional regulation of myeloid-derived suppressor cellsQ36322351
Signal transducer and activator of transcription 5 (STAT5), a crucial regulator of immune and cancer cellsQ36352260
Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor functionQ36384598
Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice.Q36410807
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteasesQ36564552
Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosisQ36564701
Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer.Q36967364
Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.Q37087293
Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironmentQ37169987
The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppressionQ37253328
Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic deliveryQ37497357
Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasisQ37744890
Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC).Q38006616
PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cellsQ38047052
Shaping gene expression in activated and resting primary macrophages by IL-10.Q38363550
The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review).Q38529820
Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasinQ38792113
Immunosuppression in liver tumors: opening the portal to effective immunotherapy.Q39026963
Abrogation of constitutive Stat3 activity circumvents cisplatin resistant ovarian cancerQ39107664
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunityQ39715226
Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastasesQ39751334
Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2.Q39876429
Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53.Q40138858
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunityQ40351340
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activityQ40372686
High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cellsQ40519826
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophilsQ40591759
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cellsQ40602668
p38 mitogen-activated protein kinase is involved in Fas ligand expression.Q40932801
JNK activation is not required for Fas-mediated apoptosisQ40944633
Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.Q41075660
Role of apoptosis resistance in immune evasion and metastasis of colorectal cancerQ41114891
Mitochondrial control of apoptosisQ41339880
Bcl-2 and the ICE family of apoptotic regulators: making a connection.Q41345463
Carcinoembryonic antigen-immunoglobulin Fc fusion protein (CEA-Fc) for identification and activation of anti-CEA immunoglobulin-T-cell receptor-modified T cells, representative of a new class of Ig fusion proteinsQ47997557
Frontline Science: Functionally impaired geriatric CAR-T cells rescued by increased α5β1 integrin expressionQ50032034
Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillanceQ57174100
Conventional liver CD4 T cells are functionally distinct and suppressed by environmental factorsQ58034341
Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153Q73617992
Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cellsQ80274418
T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastasesQ84150373
P433issue4
P304page(s)533-548
P577publication date2018-08-29
P1433published inOncogeneQ1568657
P1476titleSTAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells
P478volume38

Reverse relations

cites work (P2860)
Q97067646CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
Q90321041Candesartan ameliorates vascular smooth muscle cell proliferation via regulating miR-301b/STAT3 axis
Q92977405Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
Q92375496Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling
Q90092950Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells
Q96231527Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies
Q92731408Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells
Q102369377Monocytic and granulocytic myeloid-derived suppressor cell plasticity and differentiation are organ-specific
Q97883099P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress
Q92863682PLCA8 suppresses breast cancer apoptosis by activating the PI3k/AKT/NF-κB pathway
Q97526934Renal cancer-derived exosomes induce tumor immune tolerance by MDSCs-mediated antigen-specific immunosuppression
Q93079065STAT3, a Master Regulator of Anti-Tumor Immune Response
Q98289192STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells
Q64099576The Cancer Stem Cell Inhibitor Napabucasin (BBI608) Shows General Cytotoxicity in Biliary Tract Cancer Cells and Reduces Cancer Stem Cell Characteristics
Q97644531Upregulated TRAIL and Reduced DcR2 Mediate Apoptosis of Decidual PMN-MDSC in Unexplained Recurrent Pregnancy Loss

Search more.