Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis.

scientific article published on 3 March 2016

Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.AJPATH.2015.12.017
P8608Fatcat IDrelease_2nomoratwretzdiau2iiyvnnpq
P932PMC publication ID4861760
P698PubMed publication ID26948424

P50authorArti V ShindeQ114513566
Vikrant RaiQ42684496
Nikolaos G FrangogiannisQ56899107
Ilaria RussoQ57345537
P2093author name stringYa Su
Amit Saxena
Claudio Humeres
Waqas Hanif
Olga Frunza
P2860cites workExpression of galectin-3 modulates T-cell growth and apoptosisQ24309392
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Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosisQ24649584
CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycansQ34106221
Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesisQ34316944
Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and functionQ34356195
Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunctionQ34364121
Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failureQ34566520
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Galectin-3: a novel mediator of heart failure development and progressionQ34995162
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Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulationQ35534242
The Mac-2 antigen is a galactose-specific lectin that binds IgE.Q35596399
Galectin-3 expression and subcellular localization in senescent human fibroblastsQ73492361
Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 familyQ73931768
Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysmQ83706455
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Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages.Q35798551
Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.Q35809897
Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic MiceQ35883067
Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the communityQ36439679
Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxicationQ36456913
Systematic characterization of myocardial inflammation, repair, and remodeling in a mouse model of reperfused myocardial infarctionQ37047650
Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loadingQ37089500
IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium.Q37293969
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Galectin-1 and galectin-3 in fetal development of bovine respiratory and digestive tracts. Comparison of cell type-specific expression profiles and subcellular localization.Q38292645
Galectin-3 stimulates cell proliferationQ38330513
Galectin-3 blockade inhibits cardiac inflammation and fibrosis in experimental hyperaldosteronism and hypertensionQ38387964
Regulation of alternative macrophage activation by galectin-3.Q40016366
The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.Q41744993
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarctionQ41769718
Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cellsQ41922181
Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.Q42086638
Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction.Q42278450
Intranuclear distribution of galectin-3 in mouse 3T3 fibroblasts: comparative analyses by immunofluorescence and immunoelectron microscopyQ42824084
Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failureQ44426645
Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarctionQ44762410
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Myocardial remodeling in hypertensive Ren-2 transgenic ratsQ46720922
Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow.Q46891774
Role of colony-stimulating factor-1 in macrophage activation in tumor-bearing miceQ53995738
Galectin-3 Mediates Aldosterone-Induced Vascular FibrosisQ61187743
Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesionQ72110806
Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophagesQ72772895
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1114-1127
P577publication date2016-03-03
P1433published inThe American Journal of PathologyQ4744259
P1476titleMyocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis
P478volume186

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cites work (P2860)
Q90069019Association between Galectin-3 levels within central and peripheral venous blood, and adverse left ventricular remodelling after first acute myocardial infarction
Q88007741Authors' Reply
Q64328935Cystatin C and galectin-3 as therapeutic targets in heart failure
Q90585459Disconnect between Fibrotic Response and Right Ventricular Dysfunction
Q50542706Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy.
Q87936770Galectin-3 in the pathogenesis of heart failure: a causative mediator or simply a biomarker?
Q49670112Galectin-3 regulation of wound healing and fibrotic processes: insights for chronic skin wound therapeutics
Q51816888Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure.
Q55230733Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure.
Q90692343Moving galectin-3 closer to the goal line
Q91594685Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition
Q64061682Perindopril and a Galectin-3 Inhibitor Improve Ischemic Heart Failure in Rabbits by Reducing Gal-3 Expression and Myocardial Fibrosis
Q87883713Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload
Q90729459Post-operative acute kidney injury is associated with a biomarker of acute brain injury after paediatric cardiac surgery
Q99587532Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?
Q47171988The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling.
Q54785371Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling.

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