Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer

scientific article published on July 2011

Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2174/156800911796191024
P932PMC publication ID3670669
P698PubMed publication ID21599634

P2093author name stringW E Gillanders
D C Linehan
W G Hawkins
P Goedegebuure
A Wang-Gillam
B A Belt
J B Mitchem
M C B Tan
M R Porembka
P2860cites workDevelopment of bisphosphonatesQ21195188
CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancerQ24318416
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic nicheQ24600542
Modes of resistance to anti-angiogenic therapyQ24608005
S100 chemokines mediate bookmarking of premetastatic nichesQ24630751
Myeloid-derived suppressor cells: linking inflammation and cancerQ24641811
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 proteinQ24641894
The role of NKT cells in tumor immunityQ24648939
Inflammation and cancerQ24649640
Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancerQ24651062
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cellsQ24658240
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinomaQ24676809
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Cancer statistics, 2010Q27860525
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
PD-1 and its ligands in tolerance and immunityQ28131650
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
The tumor microenvironment and its role in promoting tumor growthQ36946019
Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cellsQ36969858
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.Q36982546
Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunityQ36996588
Creating immune privilege: active local suppression that benefits friends, but protects foes.Q37026641
Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature.Q37104501
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stromaQ37106218
Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells.Q37118160
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectivesQ37118164
High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinomaQ37222638
Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4Q37232937
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.Q37273173
Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer.Q37327260
Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition.Q37338140
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro.Q37340505
Myeloid dendritic cell: From sentinel of immunity to key player of peripheral tolerance?Q37393423
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.Q37486791
The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancerQ37487325
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammationQ37594369
Novel agents for the treatment of adenocarcinoma of the pancreasQ37614590
Immune infiltration in human tumors: a prognostic factor that should not be ignoredQ37641059
Myeloid-derived suppressor cell heterogeneity and subset definition.Q37695457
Antigen specificity of immune suppression by myeloid-derived suppressor cellsQ37864462
Mechanisms by which Activated Macrophages Inhibit Lymphocyte ResponsesQ37991335
Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trialQ38391782
The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasisQ39567775
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunityQ39715226
Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF.Q39770285
Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1.Q39901596
New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridineQ39947732
Equilibrium between host and cancer caused by effector T cells killing tumor stromaQ40006201
Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristicsQ40011425
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activityQ40013431
Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinomaQ40017876
Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 miceQ40045304
Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic headQ40068712
A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor modelQ40099109
Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 responseQ80582229
Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responsesQ80798275
Dynamics of the immune reaction to pancreatic cancer from inception to invasionQ81381605
CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitisQ81386279
Patients undergoing treatment for pancreatic adenocarcinoma can mount an effective immune response to vaccinationsQ81540982
Phenotypic and functional analysis of dendritic cells and clinical outcome in patients with high-risk melanoma treated with adjuvant granulocyte macrophage colony-stimulating factorQ81555396
CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cellsQ81598364
Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14⁻/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancerQ84156945
Immature immunosuppressive CD14+HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-signQ84256128
Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinomaQ84425427
Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen speciesQ73719137
Systemic and local immunosuppression in pancreatic cancer patientsQ73745122
Clinical significance of defective dendritic cell differentiation in cancerQ73803370
Increased presence of CD34+ cells in the peripheral blood of head and neck cancer patients and their differentiation into dendritic cellsQ73939950
Down-regulation of HLA class II and costimulatory CD86/B7-2 on circulating monocytes from melanoma patientsQ75275280
Immunological escape mechanisms in pancreatic carcinomaQ78027682
Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patientsQ79323463
1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experienceQ79369906
Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansionQ79441078
Systemic immune dysfunction in pancreatic cancer patientsQ79603775
CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancersQ79674004
Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patientsQ80480802
Type, density, and location of immune cells within human colorectal tumors predict clinical outcomeQ28131662
Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activationQ28141319
The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophilsQ28269488
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasisQ28275735
The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phaseQ28507440
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell functionQ28510096
Monocyte and macrophage heterogeneityQ29547438
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trialQ29547565
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
Regulation of immune responses by L-arginine metabolismQ29614284
Subsets of myeloid-derived suppressor cells in tumor-bearing miceQ29614297
The role of myeloid cells in the promotion of tumour angiogenesisQ29614299
Distinct role of macrophages in different tumor microenvironmentsQ29614304
IDO expression by dendritic cells: tolerance and tryptophan catabolismQ29614752
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials GroupQ29619344
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicityQ29620119
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE).Q30781823
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.Q31034362
Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunityQ33186765
A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cellsQ33335471
Modulators of arginine metabolism support cancer immunosurveillanceQ33398779
Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cellsQ33567728
Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteineQ33584867
All-trans retinoic acid and hematopoietic growth factors regulating the growth and differentiation of blast progenitors in acute promyelocytic leukemiaQ33604359
Mechanism of T cell tolerance induced by myeloid-derived suppressor cells.Q33705930
Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cellsQ33707270
Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.Q33733198
Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism.Q33763653
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumorQ33805313
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cellsQ33873201
Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activationQ33887648
Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytesQ33978763
Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cellsQ34072679
Targeting immune suppressing myeloid-derived suppressor cells in oncology.Q34082067
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironmentQ34243443
All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia.Q36703036
Reversal of tumor-mediated immunosuppressionQ36718968
The adaptive immunologic microenvironment in colorectal cancer: a novel perspectiveQ36749070
New developments of aminobisphosphonates: the double face of Janus.Q36860167
Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathwaysQ36927973
The metastatic niche: adapting the foreign soilQ36928869
Zoledronic acid has direct antiproliferative and antimetastatic effect on pancreatic carcinoma cells and acts as an antigen for delta2 gamma/delta T cellsQ40141520
Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancerQ40314081
Inflammation induces myeloid-derived suppressor cells that facilitate tumor progressionQ40338318
Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasisQ40339595
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activityQ40372686
High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cellsQ40519826
Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer.Q40605195
Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism.Q40758963
Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasoneQ41826343
Immunosuppressive CD14+HLA-DRlow/- monocytes in prostate cancerQ42183073
The terminology issue for myeloid-derived suppressor cellsQ42425163
Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients.Q42445950
Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patientsQ42482401
Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patientsQ42516923
In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory siteQ42728755
Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE₂ catabolism in myeloid cells.Q43001771
Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cellsQ43582877
Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.Q43640348
IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing miceQ44259082
Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinomaQ44427230
Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3.Q44675420
Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing miceQ44946383
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responsesQ45020410
Tumor-induced immune dysfunction: the macrophage connection.Q45113707
Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivityQ45862329
Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory propertiesQ46064310
Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patientsQ46093084
Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasionQ46440292
Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II studyQ46466364
Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic headQ46473461
Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma.Q46529900
Survival among patients with adenocarcinoma of the pancreas: a population-based study (United States).Q46672853
Cancer immunology. Cancer's bulwark against immune attack: MDS cellsQ46813671
CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stressQ46925832
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.Q51803685
Specific immune recognition of pancreatic carcinoma by patient-derived CD4 and CD8 T cells and its improvement by interferon-gamma.Q51982680
High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients.Q51987499
Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer.Q54287306
Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.Q54692947
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinomaQ56904280
Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing HostQ57054792
Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple MyelomaQ59245171
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesisQ59276609
Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor VaccineQ60311223
Early hematopoietic events during tumor growth in miceQ68794382
Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumorsQ70019545
Suppressor cells in immunodepressed bladder and prostate cancer patientsQ70532777
Suppression of antitumor immunity by macrophages in spleens of mice bearing a large MOPC-315 tumorQ70863242
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cellsQ71607047
Identification of an IL-10-producing HLA-DR-negative monocyte subset in the malignant ascites of patients with ovarian carcinoma that inhibits cytokine protein expression and proliferation of autologous T cellsQ73202053
Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancerQ73311980
Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cellsQ34312635
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axisQ34418159
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).Q34465280
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.Q34504134
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunityQ34505678
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancerQ34546440
Mast cells are essential intermediaries in regulatory T-cell toleranceQ34559099
Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitorQ34577892
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trialQ34602771
Proteomic pathway analysis reveals inflammation increases myeloid-derived suppressor cell resistance to apoptosisQ34616787
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cellsQ34723007
Modulation of the antitumor immune response by complementQ34838919
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cellsQ35052425
All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patientsQ35062106
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progressionQ35478848
Derangement of immune responses by myeloid suppressor cellsQ35573513
The biology of myeloid‐derived suppressor cells: The blessing and the curse of morphological and functional heterogeneityQ35750663
Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in boneQ35956822
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapyQ36108095
Immunotherapy for pancreatic cancer - science driving clinical progressQ36133140
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsisQ36229458
CD25+ CD4+ regulatory T-cells in cancerQ36232697
Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppressionQ36259867
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancerQ36260673
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironmentQ36306137
Myeloid derived suppressor cells in human diseasesQ36338349
Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor functionQ36384598
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patientsQ36399737
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferationQ36403539
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinomaQ36403544
Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.Q36432026
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasisQ36464443
Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicityQ36490747
Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil responseQ36528201
P433issue6
P921main subjectpancreatic cancerQ212961
P304page(s)734-751
P577publication date2011-07-01
P1433published inCurrent Cancer Drug TargetsQ332547
P1476titleMyeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer
P478volume11