Membrane-binding properties of the Factor VIII C2 domain

scientific article published on April 2011

Membrane-binding properties of the Factor VIII C2 domain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20101797
P932PMC publication ID3670696
P698PubMed publication ID21210768
P5875ResearchGate publication ID49733133

P2093author name stringJames D Baleja
Gary E Gilbert
Valerie A Novakovic
Philip J Fay
Hironao Wakabayashi
David B Cullinan
P2860cites workStructure and topography of the membrane-binding C2 domain of factor VIII in the presence of dodecylphosphocholine micellesQ24530891
Crystal structures of the membrane-binding C2 domain of human coagulation factor VQ27620579
Structure of the C2 domain of human factor VIII at 1.5 A resolutionQ27620583
Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIIIQ27632668
The tertiary structure and domain organization of coagulation factor VIIIQ27648918
Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motifQ27649435
Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complexQ27650288
Trp2313-His2315 of Factor VIII C2 Domain Is Involved in Membrane Binding: STRUCTURE OF A COMPLEX BETWEEN THE C2 DOMAIN AND AN INHIBITOR OF MEMBRANE BINDINGQ27659074
Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as determined by NMR spectroscopyQ27730428
Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitorQ28115761
Molecular cloning of a cDNA encoding human antihaemophilic factorQ28268498
Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserineQ28299233
Binding of human factor VIII to phospholipid vesiclesQ28630342
Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated plateletsQ28631517
cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequencesQ33790760
Factor VIII lacking the C2 domain retains cofactor activity in vitroQ34055694
A simple method for the preparation of homogeneous phospholipid vesiclesQ34405356
Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activationQ36447889
Coagulation factors V and VIII and ceruloplasmin constitute a family of structurally related proteinsQ37576606
The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX.Q38362540
Mutation of the surface-exposed amino acid Trp to Ala in the FVIII C2 domain results in defective secretion of the otherwise functional proteinQ40555265
Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activityQ43290531
Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifsQ43792218
Deletion analysis of recombinant human factor V. Evidence for a phosphatidylserine binding site in the second C-type domainQ44106754
The Gla domain of factor IXa binds to factor VIIIa in the tenase complexQ44463045
Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activityQ44727130
Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor XaseQ44861371
Disruption of protein-membrane binding and identification of small-molecule inhibitors of coagulation factor VIII.Q45110663
Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesisQ45865459
Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activitiesQ45878659
The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complexQ46220531
Role of the C2 domain of factor VIIIa in the assembly of factor-X activating complex on the platelet membraneQ46756615
Characterization of the human factor VIII geneQ48385931
The preparation and phospholipid binding property of the C2 domain of human factor VIIIQ50331339
Specificity of phosphatidylserine-containing membrane binding sites for factor VIII. Studies with model membranes supported by glass microspheres (lipospheres).Q52416182
Factor VIII procoagulant protein interacts with phospholipid vesicles via its 80 kDa light chainQ67245901
The binding of factor Va to phospholipid vesiclesQ67919544
The association of human coagulation factors VIII, IXa and X with phospholipid vesicles involves both electrostatic and hydrophobic interactionsQ68028824
Membrane binding kinetics of factor VIII indicate a complex binding processQ70660197
Localization of a factor X interactive site in the A1 subunit of factor VIIIaQ71985134
A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserineQ72076617
Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive siteQ72108212
Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserineQ72927413
Amphipathic helices support function of blood coagulation factor IXaQ73015517
Functional analyses of two cellular binding domains of bovine lactadherinQ73815267
Inhibitory anti-factor V antibodies bind to the factor V C2 domain and are associated with hemorrhagic manifestationsQ74576919
Phospholipid-binding domain of factor VIII is involved in endothelial cell-mediated activation of factor X by factor IXaQ77743425
Anticoagulant effects of a synthetic peptide containing residues Thr-2253-Gln-2270 within factor VIII C2 domain that selectively inhibits factor Xa-catalysed factor VIII activationQ77748060
Immunodominant T-cell epitopes in the factor VIII C2 domain are located within an inhibitory antibody binding siteQ80534658
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)187-196
P577publication date2011-04-01
P1433published inBiochemical JournalQ864221
P1476titleMembrane-binding properties of the Factor VIII C2 domain
P478volume435

Reverse relations

cites work (P2860)
Q27680655Antibacterial membrane attack by a pore-forming intestinal C-type lectin
Q44781327Backbone resonance assignments of the C2 domain of coagulation factor VIII.
Q30153398Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.
Q30384710Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes.
Q27677560Domain organization of membrane-bound factor VIII.
Q35688388In situ quantification of protein binding to the plasma membrane.
Q37915629Localized amyloids important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta
Q41316755Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail
Q42425297Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer
Q42581565Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine
Q30353558Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa

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