The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex

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The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M804955200
P8608Fatcat IDrelease_3y3byxucubh6xfnsuet66o3gni
P698PubMed publication ID19047063
P5875ResearchGate publication ID23559996

P50authorMidori ShimaQ111804989
P2093author name stringAkira Yoshioka
Yoichi Sakata
Keiji Nogami
Katsumi Nishiya
Masahiro Takeyama
Kenichi Ogiwara
Tetsuhiro Soeda
P2860cites workA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Structure of the C2 domain of human factor VIII at 1.5 A resolutionQ27620583
Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complexQ27650288
Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IXQ27732837
Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIaQ28116089
Molecular cloning of a cDNA encoding human antihaemophilic factorQ28268498
Structure of human factor VIIIQ28630991
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.Q31775088
Structure-function relationships in factor IX and factor IXa.Q35055282
Sequence of the murine factor VIII cDNA.Q36763337
Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteasesQ37289290
The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX.Q38362540
Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa bindingQ40418012
Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIaQ43560122
3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallographyQ43878410
The Gla domain of factor IXa binds to factor VIIIa in the tenase complexQ44463045
Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor XaseQ44861371
Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domainQ44912906
Factor VIII inhibitors in mild and moderate-severity haemophilia A.Q45855037
Expression of active human factor VIII from recombinant DNA clonesQ45862746
Specific detection of human coagulation factor IX in cynomolgus macaquesQ45873385
Common inhibitory effects of human anti-C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factorQ45875920
Real-time competitive kinetic analysis of interactions between low-molecular-weight ligands in solution and surface-immobilized receptorsQ47370870
The A2 subunit of factor VIIIa modulates the active site of factor IXa.Q47828224
Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance: use of nonlinear least squares analysis methods.Q52392958
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3379-3388
P577publication date2008-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex
P478volume284

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cites work (P2860)
Q37441223Activation mechanisms of coagulation factor IX.
Q30153398Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.
Q30384710Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes.
Q57803175Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity
Q52666862Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.
Q47950005Heme binds to factor VIII and inhibits its interaction with activated factor IX.
Q84798069Mechanisms of factor VIIa‐catalyzed activation of factor VIII
Q36896861Membrane-binding properties of the Factor VIII C2 domain
Q45878590Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.
Q41905130Modification of interdomain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity
Q42187640Next generation FIX muteins with FVIII-independent activity for alternative treatment of hemophilia A.
Q36310238Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody
Q27680123Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes

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