Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity

scientific article published on 26 October 2007

Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/PR700571D
P932PMC publication ID2547408
P698PubMed publication ID17960875
P5875ResearchGate publication ID5884743

P2093author name stringYinsheng Wang
Qingchun Zhang
P2860cites workThe AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6Q24295612
HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic functionQ24338503
Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-YQ24633159
Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependentQ27739821
The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motifQ27741511
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factorsQ28118264
HMGI/Y proteins: flexible regulators of transcription and chromatin structureQ28201754
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2Q28210189
Pinning down proline-directed phosphorylation signalingQ28215887
Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin proteinQ28242474
The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structureQ28259556
Identification of sites on chromosomal protein HMG-I phosphorylated by casein kinase IIQ28280083
Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinomaQ28283657
Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2Q28588947
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanismQ29614787
Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulationsQ29615346
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growthQ30732289
Discovering high mobility group A molecular partners in tumour cellsQ30780691
Tandem mass spectrometry for the examination of the posttranslational modifications of high-mobility group A1 proteins: symmetric and asymmetric dimethylation of Arg25 in HMGA1a proteinQ31160572
Fragmentation of phosphopeptides by atmospheric pressure MALDI and ESI/Ion trap mass spectrometryQ32067278
HMGA proteins: isolation, biochemical modifications, and nucleosome interactionsQ33197876
Acetylation and phosphorylation of high-mobility group A1 proteins in PC-3 human tumor cellsQ33245710
A mass spectrometric study on the in vitro methylation of HMGA1a and HMGA1b proteins by PRMTs: methylation specificity, the effect of binding to AT-rich duplex DNA, and the effect of C-terminal phosphorylationQ33286747
A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteinsQ33290698
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiationQ33891341
Distinct organization of DNA complexes of various HMGI/Y family proteins and their modulation upon mitotic phosphorylationQ33921793
Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.Q33928378
Molecular biology of HMGA proteins: hubs of nuclear functionQ34095287
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.Q34108288
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissuesQ34110016
Posttranscriptional gene regulation and specific binding of the nonhistone protein HMG-I by the 3' untranslated region of bovine interleukin 2 cDNA.Q34346833
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancerQ34347197
A mammalian high mobility group protein recognizes any stretch of six A.T base pairs in duplex DNA.Q35592304
A method to determine the ionization efficiency change of peptides caused by phosphorylationQ36168296
Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y).Q36438182
Proline-directed protein phosphorylation and cell cycle regulationQ37102170
Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: reduction of binding affinityQ37413109
Multivalent DNA-binding properties of the HMG-1 proteinsQ37539021
Substrates for p34cdc2: in vivo veritas?Q37925623
Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycinQ38291149
Protein footprinting reveals specific binding modes of a high mobility group protein I to DNAs of different conformationQ38335074
Intra- and intermolecular cooperative binding of high-mobility-group protein I(Y) to the beta-interferon promoterQ40022546
Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cellsQ40186775
HMGA1 inhibits the function of p53 family members in thyroid cancer cells.Q40304192
HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damageQ40421589
Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of GrouchoQ40440527
Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosisQ40598361
High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function.Q41080193
Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteinsQ41205647
Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genesQ41344654
Mechanisms of p34cdc2 regulationQ43182453
A link between apoptosis and degree of phosphorylation of high mobility group A1a protein in leukemic cellsQ43516503
Coordination of a transcriptional switch by HMGI(Y) acetylationQ43703056
During apoptosis of tumor cells HMGA1a protein undergoes methylation: identification of the modification site by mass spectrometryQ44373391
Increase of HMGA1a protein methylation is a distinctive characteristic of leukaemic cells induced to undergo apoptosisQ44407044
Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosomeQ44646118
Mass spectrometric analysis of high-mobility group proteins and their post-translational modifications in normal and cancerous human breast tissues.Q45975124
Purification and postsynthetic modifications of Friend erythroleukemic cell high mobility group protein HMG-I.Q46146440
Dynamic interaction of HMGA1a proteins with chromatinQ47302322
Constitutive phosphorylation of the acidic tails of the high mobility group 1 proteins by casein kinase II alters their conformation, stability, and DNA binding specificity.Q52571445
Consecutive steps of phosphorylation affect conformation and DNA binding of the chironomus high mobility group A protein.Q52587955
Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.Q53568110
A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome.Q53910276
Phosphorylation of the Transactivation Domain of Pax6 by Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein KinaseQ57271959
Mass spectrometric analysis of the HMGY protein from Lewis lung carcinoma. Identification of phosphorylation sitesQ67926104
The metaphase specific phosphorylation of HMG IQ68475117
On the phosphorylation of low molecular mass HMG (high mobility group) proteins in Ehrlich ascites cellsQ69881599
Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma and neurogranin/RC3 genesQ73315938
Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervixQ74150837
Fragmentation of phosphopeptides in an ion trap mass spectrometerQ77482776
Electrospray tandem mass spectrometric studies of phosphopeptides and phosphopeptide analoguesQ78539826
Improving fragmentation of poorly fragmenting peptides and phosphopeptides during collision-induced dissociation by malondialdehyde modification of arginine residuesQ80407899
Neutral loss-based phosphopeptide recognition: a collection of caveatsQ80479455
Cdk1: the dominant sibling of Cdk2Q80964932
Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosisQ83855474
P4510describes a project that usesImageQuantQ112270642
P433issue12
P921main subjectphosphorylationQ242736
P304page(s)4711-4719
P577publication date2007-10-26
P1433published inJournal of Proteome ResearchQ3186939
P1476titleHomeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity
P478volume6

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cites work (P2860)
Q46022392An RNA interference screen identifies druggable regulators of MeCP2 stability.
Q38709288Circulating high mobility group AT-hook 2 and pleomorphic adenoma gene 1 in blood of patients with oral squamous cell carcinoma.
Q90467625Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice
Q39182057Effect of silencing of high mobility group A2 gene on gastric cancer MKN-45 cells
Q33637999HMG modifications and nuclear function
Q38264460HMGA proteins as modulators of chromatin structure during transcriptional activation.
Q37015673High mobility group proteins and their post-translational modifications
Q28073422Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome
Q34251143Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response
Q47071467Homeodomain-interacting protein kinase (Hipk) phosphorylates the small SPOC family protein Spenito
Q39137648Interaction and cooperation of the CCAAT-box enhancer-binding protein β (C/EBPβ) with the homeodomain-interacting protein kinase 2 (Hipk2).
Q92147199Phosphorylation orchestrates the structural ensemble of the intrinsically disordered protein HMGA1a and modulates its DNA binding to the NFκB promoter
Q38101509Posttranslational modifications regulate HIPK2, a driver of proliferative diseases
Q33613335The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development
Q36282953The dynamics of HMG protein-chromatin interactions in living cells
Q24311659The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4

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