The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6

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The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6 is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M510231200
P8608Fatcat IDrelease_wrpuxk3lsfgdncjog47ubfanhm
P698PubMed publication ID16293633

P50authorRiccardo SgarraQ37375473
P2093author name stringBarbara Spolaore
Guidalberto Manfioletti
Jaeho Lee
Mark T Bedford
Michela A Tessari
Sandro Altamura
Vincenzo Giancotti
P2860cites workThe novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificityQ24291936
Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2Q24300865
Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3)Q24306650
PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginineQ24307732
PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulationQ24310138
PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificityQ24320263
PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in ProteinsQ56227906
Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1aQ24322755
Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)Q24329201
PABP1 identified as an arginine methyltransferase substrate using high-density protein arraysQ24522567
Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expressionQ24558697
cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypesQ24626142
Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate PeptidesQ27641186
The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motifQ27741511
HMGI/Y proteins: flexible regulators of transcription and chromatin structureQ28201754
Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1Q28218037
Methylation of histone H3 by coactivator-associated arginine methyltransferase 1Q28589913
Arginine methylation an emerging regulator of protein functionQ29617311
Discovering high mobility group A molecular partners in tumour cellsQ30780691
Differential in vivo modifications of the HMGI(Y) nonhistone chromatin proteins modulate nucleosome and DNA interactionsQ30884734
Tandem mass spectrometry for the examination of the posttranslational modifications of high-mobility group A1 proteins: symmetric and asymmetric dimethylation of Arg25 in HMGA1a proteinQ31160572
In vivo posttranslational modifications of the high mobility group A1a proteins in breast cancer cells of differing metastatic potentialQ33206483
Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteinsQ33209784
Architecture of high mobility group protein I-C.DNA complex and its perturbation upon phosphorylation by Cdc2 kinase.Q33886632
Molecular biology of HMGA proteins: hubs of nuclear functionQ34095287
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancerQ34347197
Role of the high mobility group A proteins in human lipomasQ34384823
Histones and histone modificationsQ35842800
Role of protein methylation in regulation of transcriptionQ35915940
Reversing histone methylationQ36240192
Mechanism by which the IFN-beta enhanceosome activates transcriptionQ36666284
Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: reduction of binding affinityQ37413109
Multivalent DNA-binding properties of the HMG-1 proteinsQ37539021
NF-kappaB mediated transcriptional activation is enhanced by the architectural factor HMGI-C.Q38338382
Arginine methylation of scaffold attachment factor A by heterogeneous nuclear ribonucleoprotein particle-associated PRMT1.Q40516117
The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosomeQ42136458
A link between apoptosis and degree of phosphorylation of high mobility group A1a protein in leukemic cellsQ43516503
Coordination of a transcriptional switch by HMGI(Y) acetylationQ43703056
During apoptosis of tumor cells HMGA1a protein undergoes methylation: identification of the modification site by mass spectrometryQ44373391
Increase of HMGA1a protein methylation is a distinctive characteristic of leukaemic cells induced to undergo apoptosisQ44407044
Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidiansQ47073419
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)3764-72
P577publication date2006-02-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6
P478volume281

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cites work (P2860)
Q33983567A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator
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Q37410634Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat.
Q28585783Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification
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Q35876542Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a.
Q27681586Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei
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Q34721443High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma
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Q28251805Mapping intact protein isoforms in discovery mode using top-down proteomics
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Q51932859Over-expression of an AT-hook gene, AHL22, delays flowering and inhibits the elongation of the hypocotyl in Arabidopsis thaliana.
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Q41583100pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication

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