Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells.

scientific article published on 25 March 2010

Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/CANCERS2020233
P932PMC publication ID3835077
P698PubMed publication ID24281069
P5875ResearchGate publication ID258954846

P50authorAntonino BelfioreQ57028878
P2093author name stringHaim Werner
Rive Sarfstein
P2860cites workEstrogen receptor alpha rapidly activates the IGF-1 receptor pathwayQ22253479
The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6Q24295612
pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167Q24533505
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor geneQ28118453
Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancerQ28237194
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysisQ28258638
Molecular and cellular aspects of the insulin-like growth factor I receptorQ28288023
Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.Q52584374
Circulating concentrations of insulin-like growth factor I and risk of breast cancerQ57751183
Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen Regulation of Insulin Receptor Substrate-1 Expressionin Vitroandin VivoQ62267728
Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor ActionQ62267755
Analysis of the human type I insulin-like growth factor receptor promoter regionQ67693079
Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancerQ69656778
Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancerQ72526379
Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancerQ73259722
A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor IQ73274526
The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissueQ74295881
The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinomaQ80282025
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinaseQ29617567
Improving large-scale proteomics by clustering of mass spectrometry data.Q30917029
Function of the IGF-I receptor in breast cancerQ33904112
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cellsQ33986318
Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.Q34319231
Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic miceQ34578428
Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met, involves exclusion from the endocytic degradative pathway.Q34632213
The IGFI receptor gene: a molecular target for disrupted transcription factorsQ35036870
Type 1 IGF receptor in human breast diseasesQ35465137
Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene productQ36378010
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblastsQ36653985
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptorQ36696132
Implications of applied research for prognosis and therapy of breast cancerQ37074906
Affinity purification of sequence-specific DNA binding proteinsQ37394403
Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start siteQ38308828
Structural and functional analysis of the insulin-like growth factor I receptor gene promoterQ38325320
Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutationsQ40086113
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivoQ40099249
Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.Q40196099
The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cellsQ40369437
The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cellsQ40387187
The insulin-like growth factor system as a target in breast cancerQ40396511
In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumorsQ40433669
Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.Q40519472
WT1-p53 interactions in insulin-like growth factor-I receptor gene regulationQ40688483
Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growthQ40789384
The role of the insulin-like growth factor system in human cancerQ41035980
The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion proteinQ41175804
Estradiol Down-Regulates the Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptor Gene and Induces Cathepsin-D in Breast Cancer Cells: A Receptor Saturation Mechanism to Increase the Secretion of Lysosomal ProenzymesQ41682889
Role of estrogen-induced insulin-like growth factors in the proliferation of human breast cancer cellsQ41710584
Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cellsQ41711044
Type I insulin-like growth factor receptor function in breast cancer.Q41727242
IGF system components as prognostic markers in breast cancer.Q41727250
Insulin-like growth factor receptor expression and function in human breast cancerQ41753631
Insulin receptor substrate 1 is a target for the pure antiestrogen ICI 182,780 in breast cancer cellsQ42470095
Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT elementQ42474843
Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiationQ42798205
ATM is a target for positive regulation by E2F-1.Q42806424
An intact and functional soluble form of the insulin receptor is secreted by cultured cells.Q42806584
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathwayQ43516376
BRCA1–Sp1 interactions in transcriptional regulation of the IGF‐IR geneQ44411062
Insulin-like growth factor-II (IGF-II): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-I receptorQ44490891
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectestrogenQ277954
preproinsulinQ7240673
P304page(s)233-261
P577publication date2010-03-25
P1433published inCancersQ27722963
P1476titleIdentification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells
P478volume2

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cites work (P2860)
Q38641329Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies
Q26742114Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways
Q36074111Insulin-like growth factor-1 signaling in renal cell carcinoma
Q35710097Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells
Q28486318Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners
Q92296751Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors
Q39043458Prognostic value of cross-omics screening for kidney clear cell renal cancer survival
Q35535296Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation
Q42409060TMPRSS2-ERG fusion protein regulates insulin-like growth factor-1 receptor (IGF1R) gene expression in prostate cancer: involvement of transcription factor Sp1.
Q93104633The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells
Q37551261The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells
Q35105295The role of the insulin-like growth factor-1 system in breast cancer
Q97421864Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter
Q37941372Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer
Q46894191Werner et al. Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells

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