The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein

scientific article published on August 1996

The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.271.32.19304
P698PubMed publication ID8702614
P5875ResearchGate publication ID14498961

P50authorDerek LeRoithQ5262136
P2093author name stringWerner H
Rauscher FJ 3rd
Karnieli E
Benjamin LE
P2860cites workGene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumoursQ24298221
EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft partsQ24317557
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1Q24629399
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locusQ28236741
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumpingQ28236877
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERGQ28252253
Physical and functional interaction between WT1 and p53 proteinsQ28575245
Role of insulin-like growth factors in embryonic and postnatal growthQ29620034
Developmental regulation of the rat insulin-like growth factor I receptor geneQ34307361
Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumorQ34676847
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.Q36374350
Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene productQ36378010
Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expressionQ36552308
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblastsQ36653985
A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptorQ36656841
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptorQ36696132
Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumorQ37874427
DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1Q38307463
Novel Oncogenic Mutations in the WT1 Wilms' Tumor Suppressor Gene: A t(11;22) Fuses the Ewing's Sarcoma Gene, EWS1, to WT1 in Desmoplastic Small Round Cell TumorQ38313089
Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequenceQ38338176
Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysisQ40016977
Transcriptional repression mediated by the WT1 Wilms tumor gene productQ41661461
Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor geneQ41744244
Chromosomal translocations in human cancer.Q52512616
The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric TranscriptsQ57756648
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemiaQ59080605
Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpointsQ60035789
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)Q60060443
A Novel Reciprocal Chromosome Translocation t(11;22)(p13;q12) in an Intraabdominal Desmoplastic Small Round-Cell TumorQ67487724
Cytogenetic abnormalities in an intraabdominal desmoplastic small cell tumorQ67992109
Chromosome translocation in peripheral neuroepitheliomaQ71438112
Translocation (11;22)(p13;q12): Primary change in intra‐abdominal desmoplastic small round cell tumorQ72087891
Intra-abdominal desmoplastic small cell tumor: a light microscopic, immunocytochemical, ultrastructural, and flow cytometric studyQ72931317
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)19304-19309
P577publication date1996-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein
P478volume271

Reverse relations

cites work (P2860)
Q37423988A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease.
Q38347709A tetraspanin-family protein, T-cell acute lymphoblastic leukemia-associated antigen 1, is induced by the Ewing's sarcoma-Wilms' tumor 1 fusion protein of desmoplastic small round-cell tumor
Q33654843Antiangiogenic effects in patients with progressive desmoplastic small round cell tumor: data from the French national registry dedicated to the use of off-labeled targeted therapy in sarcoma (OUTC's)
Q33408460Characterization of inhibitory anti-insulin-like growth factor receptor antibodies with different epitope specificity and ligand-blocking properties: implications for mechanism of action in vivo
Q33259363Coexpression of an unusual form of the EWS-WT1 fusion transcript and interleukin 2/15 receptor betamRNA in a desmoplastic small round cell tumour
Q39025917Desmoplastic small round cell tumor 20 years after its discovery
Q44576314Desmoplastic small round cell tumor presenting as a neck mass: a case report
Q33304145Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical and molecular study of four patients
Q34250202Desmoplastic small round cell tumour: characteristics and prognostic factors of 41 patients and review of the literature
Q74462743Detection of EWS-WT1 fusion mRNA in ascites of a patient with desmoplastic small round cell tumor by RT-PCR
Q37512587Development of IGF-IR Inhibitors in Pediatric Sarcomas.
Q52531695Dysregulation of the type 1 IGF receptor as a paradigm in tumor progression.
Q37993924Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors.
Q35587544Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour
Q38972581GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4
Q92702627IGF2/IGF1R Signaling as a Therapeutic Target in MYB-Positive Adenoid Cystic Carcinomas and Other Fusion Gene-Driven Tumors
Q37328268Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells.
Q34223145Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein
Q44259989Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis.
Q38290072Induction of the interleukin-2/15 receptor beta-chain by the EWS-WT1 translocation product.
Q39108056Lost miRNA surveillance of Notch, IGFR pathway--road to sarcomagenesis
Q36743270Modification of EWS/WT1 functional properties by phosphorylation
Q30168994Modulation of EWS/WT1 activity by the v-Src protein tyrosine kinase
Q58776408Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers
Q33747747Molecular strategies for detecting chromosomal translocations in soft tissue tumors (review).
Q35508728Myeloablative chemotherapy with autologous stem cell transplant for desmoplastic small round cell tumor
Q49887886Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway
Q34661253Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product
Q36163571Role of insulin-like growth factor 1 receptor signalling in cancer
Q30395770Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer
Q28257266Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src
Q41727239Structure and function of the insulin-like growth factor I receptor
Q21285014Targeted therapies in sarcomas: challenging the challenge
Q37975246Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy
Q48684446The IGF-I receptor in cell growth, transformation and apoptosis
Q35036870The IGFI receptor gene: a molecular target for disrupted transcription factors
Q28142781The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties
Q40542365The oncogenic fusion protein EWS/NOR-1 induces transformation of CFK2 chondrogenic cells
Q34001125The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes.
Q38612221The role of insulin-like growth factor system in soft tissue sarcomas: from physiopathology to targeted therapeutic approaches
Q37931268Therapeutic pipeline for soft-tissue sarcoma
Q40653110Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein
Q97681227Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children's Oncology Group
Q34990678Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. desmoplastic small round-cell tumors
Q37973027Updates on the multimodality management of desmoplastic small round cell tumor
Q28191433WT1 proteins: functions in growth and differentiation