Therapeutic approaches for prion disorders

scientific article published on August 2007

Therapeutic approaches for prion disorders is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1586/14787210.5.4.613
P698PubMed publication ID17678425

P2093author name stringStefan Weiss
Inga Zerr
Chantal Zuber
Daphne Nikles
Karen Vana
Heike Ludewigs
P2860cites workAmphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters.Q48263573
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Intracerebroventricular delivery of dominant negative prion protein in a mouse model of iatrogenic Creutzfeldt-Jakob disease after dura graft transplantationQ48506670
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A novel generation of heparan sulfate mimetics for the treatment of prion diseases.Q51834544
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Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.Q54037114
Porphyrin and phthalocyanine antiscrapie compounds.Q54061556
Potent inhibition of scrapie-associated PrP accumulation by congo redQ54131452
Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection.Q54197273
Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells.Q54528615
Failure of interferon to modify Creutzfeldt-Jakob diseaseQ55260779
Cationic Lipopolyamines Induce Degradation of PrPSc in Scrapie-Infected Mouse Neuroblastoma CellsQ57375636
Monoclonal antibodies inhibit prion replication and delay the development of prion diseaseQ59053964
Branched polyamines cure prion-infected neuroblastoma cellsQ24529092
Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion diseaseQ24550300
Elimination of prions by branched polyamines and implications for therapeuticsQ24646752
Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected miceQ24673105
Formation of native prions from minimal components in vitroQ24676353
Akinetic mutism as a classification criterion for the diagnosis of Creutzfeldt-Jakob diseaseQ24680088
Evaluation of quinacrine treatment for prion diseasesQ24682427
NMR structure of the mouse prion protein domain PrP(121-231)Q27733163
Mice devoid of PrP are resistant to scrapieQ28249108
Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptorQ28363055
Production of cattle lacking prion protein.Q30492928
Tetracyclines affect prion infectivityQ30531528
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Clinical diagnosis and differential diagnosis of CJD and vCJD. With special emphasis on laboratory testsQ30698122
Novel single chain antibodies to the prion protein identified by phage displayQ30826530
Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease.Q30983435
Clinical course in young patients with sporadic Creutzfeldt-Jakob diseaseQ30995751
Anti-amyloidogenic activity of tetracyclines: studies in vitro.Q31861027
Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replicationQ33225026
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.Q33248701
Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodiesQ33843281
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibodyQ33930771
Acridine and phenothiazine derivatives as pharmacotherapeutics for prion diseaseQ33933969
Dominant-negative inhibition of prion replication in transgenic miceQ34191612
A prion protein epitope selective for the pathologically misfolded conformationQ34201802
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.Q34273746
A porphyrin increases survival time of mice after intracerebral prion infectionQ34352240
A new variant of Creutzfeldt-Jakob disease in the UK.Q34374893
Compassionate use of quinacrine in Creutzfeldt-Jakob disease fails to show significant effectsQ34380330
Mucosal vaccination delays or prevents prion infection via an oral route.Q34416637
Suppression of prion protein in livestock by RNA interference.Q34506076
Potent antiscrapie activities of degenerate phosphorothioate oligonucleotidesQ34509751
Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro.Q34509758
Unsuccessful intraventricular pentosan polysulphate treatment of variant Creutzfeldt-Jakob diseaseQ34511219
Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesisQ34521384
CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease.Q34559367
Infectious prions in the saliva and blood of deer with chronic wasting diseaseQ34571835
Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor.Q35085199
MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapieQ35121108
Patients with Alzheimer's disease and dementia with Lewy bodies mistaken for Creutzfeldt-Jakob diseaseQ35462665
The neuropsychology of variant CJD: a comparative study with inherited and sporadic forms of prion disease.Q35486440
Early cognitive decline in Creutzfeldt-Jakob disease associated with human growth hormone treatment.Q35560261
Prion protein-specific antibodies for therapeutic intervention of transmissible spongiform encephalopathiesQ36407253
Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyaninesQ36518232
A systematic review of prion therapeutics in experimental modelsQ36525632
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagationQ36581272
Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPScQ36672125
Novel aspects of prions, their receptor molecules, and innovative approaches for TSE therapyQ36676179
Therapeutic approaches targeting the prion receptor LRP/LR.Q36820454
Creutzfeldt-Jakob disease treated with amantidine: A report of two casesQ37093073
Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.Q37569845
Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal modelsQ37730189
DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregationQ38295713
Prion-protein-specific aptamer reduces PrPSc formationQ38363420
DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challengeQ38761934
Short report: Creutzfeldt-Jakob disease treated with amantadineQ39227068
The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion proteinQ39644598
Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations.Q39692874
Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation.Q39719132
Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseasesQ40166050
Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.Q40168614
The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanesQ40245615
Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).Q40283366
Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.Q40477337
Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies.Q40483672
Cell-surface retention of PrPC by anti-PrP antibody prevents protease-resistant PrP formationQ40504536
The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.Q40537139
PrPSc binding antibodies are potent inhibitors of prion replication in cell lines.Q40558013
Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA.Q40569086
Specific inhibition of pathological prion protein accumulation by small interfering RNAsQ40646170
Inhibition of scrapie-associated PrP accumulation. Probing the role of glycosaminoglycans in amyloidogenesisQ40654314
The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cellsQ40666067
Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP releaseQ40734071
The anti-prion activity of Congo red. Putative mechanismQ41062006
The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cellsQ41077192
Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP.Q41904973
Long term survival in a patient with variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulphateQ42765732
Prion (PrPSc)-specific epitope defined by a monoclonal antibodyQ42816365
Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia, and CanadaQ43218822
Normal development and behaviour of mice lacking the neuronal cell-surface PrP proteinQ43522858
Effects of the polyene antibiotic derivative MS-8209 on the astrocyte lysosomal system of scrapie-infected hamstersQ44023828
Quinacrine-induced cytolytic hepatitis in sporadic Creutzfeldt-Jakob diseaseQ44383471
Amphotericin B binds to amyloid fibrils and delays their formation: a therapeutic mechanism?Q44446729
Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected miceQ44559545
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind studyQ44790692
Differential diagnosis of 201 possible Creutzfeldt-Jakob disease patientsQ44795783
Toxicity of quinacrine can be reduced by co-administration of P-glycoprotein inhibitor in sporadic Creutzfeldt-Jakob diseaseQ45239690
Antibodies inhibit prion propagation and clear cell cultures of prion infectivityQ46161882
Polymerization of murine recombinant prion protein in nucleic acid solutionQ46243624
Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.Q46501596
Sporadic Creutzfeldt-Jakob disease: clinical and diagnostic characteristics of the rare VV1 typeQ46750178
KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivityQ46804222
Results of quinacrine administration to patients with Creutzfeldt-Jakob diseaseQ48087933
Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted diseaseQ48126727
RNA molecules stimulate prion protein conversionQ48170423
Creutzfeldt-Jakob disease in Germany: a prospective 12-year surveillanceQ48181910
P433issue4
P921main subjectprion protein familyQ24724413
P304page(s)613-630
P577publication date2007-08-01
P1433published inExpert Review of Anti-infective TherapyQ15734432
P1476titleTherapeutic approaches for prion disorders
P478volume5

Reverse relations

cites work (P2860)
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Q39856446The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein.
Q39990152siRNA-mediated silencing of the 37/67-kDa high affinity laminin receptor in Hep3B cells induces apoptosis.

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