CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

scientific article published on 23 January 2013

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011367227
P356DOI10.1186/AR4151
P932PMC publication ID3672729
P698PubMed publication ID23343403
P5875ResearchGate publication ID235366127

P2093author name stringChih-Hsin Tang
Chin-Jung Hsu
Ju-Fang Liu
Chun-Han Hou
Sheng-Mon Hou
P2860cites workWISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumorsQ22008485
A novel role of CCN3 in regulating endothelial inflammationQ24306569
WISP-1 is a Wnt-1- and beta-catenin-responsive oncogeneQ24608963
WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte deathQ24642477
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8Q28609808
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathwayQ28615706
Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathwaysQ30424909
Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford StudyQ33739798
IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritisQ33817665
Age-related changes in the musculoskeletal system and the development of osteoarthritisQ34062933
Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.Q34152999
The CCN family: a new class of inflammation modulators?Q34153304
The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction.Q34417592
Catalysis by a multiprotein IkappaB kinase complexQ34743658
The CCN family: a new stimulus packageQ35194555
The role of cytokines in cartilage matrix degeneration in osteoarthritis.Q35916137
Metastasis and AKT activationQ37279743
Obesity, the PI3K/Akt signal pathway and colon cancerQ37519914
To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapyQ37701895
Integrins and signal transductionQ37765261
Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts.Q38290654
Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts.Q38325637
Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways.Q39465565
CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cellsQ39578305
Detection of vascular endothelial growth factor (VEGF) in moderate osteoarthritis in a rabbit model.Q39638997
Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathwayQ39736733
Bradykinin enhances cell migration in human chondrosarcoma cells through BK receptor signaling pathwaysQ39779760
Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritisQ39866174
Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domainQ40638509
Transcriptional regulation of the interleukin-6 gene in mesangial cellsQ40942132
Will o' the wisp: CCN4 as a novel molecular target in osteoarthritisQ41768626
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytesQ42013999
The CCL5/CCR5 axis promotes interleukin‐6 production in human synovial fibroblastsQ42878657
Differential gene expression of scopolamine-treated rat hippocampus-application of cDNA microarray technologyQ44485460
Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK.Q44995332
Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.Q45748576
Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway.Q45918486
A single-chain integrin?Q46449844
Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reactionQ47749141
Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age.Q51702354
HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src, Akt and NF-κB pathways.Q54594317
Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritisQ60454905
Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced eventsQ79394740
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathwayQ81386355
Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai populationQ84815355
P4510describes a project that usesImageQuantQ112270642
P433issue1
P921main subjectNF-κBQ411114
P304page(s)R19
P577publication date2013-01-23
P1433published inArthritis Research and TherapyQ15757229
P1476titleCCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts
P478volume15

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cites work (P2860)
Q40095754A functional analysis of Wnt inducible signalling pathway protein -1 (WISP-1/CCN4).
Q36933268Activation of protease-activated receptor 2-mediated signaling by mast cell tryptase modulates cytokine production in primary cultured astrocytes
Q53306751Advanced glycation end-products induced VEGF production and inflammatory responses in human synoviocytes via RAGE-NF-κB pathway activation.
Q36562200Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma
Q28567429CCN4 regulates vascular smooth muscle cell migration and proliferation
Q47131296CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts
Q26751449Cell surface receptors for CCN proteins
Q38258015Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions
Q39038707Concomitant activation of the PI3K/Akt and ERK1/2 signalling is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cells
Q39125163Dual effect of WISP-1 in diverse pathological processes
Q47169599Effects of baicalein on IL-1β-induced inflammation and apoptosis in rat articular chondrocytes
Q37681712Epigenetic modifications of interleukin-6 in synovial fibroblasts from osteoarthritis patients
Q42135044Excessive activation of the TLR9/TGF-β1/PDGF-B pathway in the peripheral blood of patients with systemic lupus erythematosus
Q35632717Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway
Q26999676Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system
Q59339933Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-αvβ5 integrin pathway in TLR4-mediated inflammation and injury
Q36585324Picking a bone with WISP1 (CCN4): new strategies against degenerative joint disease
Q36317379Role of WNT1-inducible-signaling pathway protein 1 in etoposide resistance in lung adenocarcinoma A549 cells
Q33729855Shen-Yuan-Dan Capsule Inhibiting Inflammatory Reaction by Regulating Insulin Receptor Substrate 1/PI3K/Akt/NF-κB Signaling Pathway in Apoliprotein E Knockout Mice Fed with a High-Fat Diet.
Q33755839Signaling pathways in cartilage repair
Q91868423WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors
Q38381157WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts.
Q26775922Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis
Q52926003¹⁸F-FPRGD₂ PET/CT imaging of musculoskeletal disorders.

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