Integrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expression

scientific article published on 18 May 2016

Integrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expression is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1002504871
P356DOI10.1038/SREP26252
P932PMC publication ID4870583
P698PubMed publication ID27188220

P2093author name stringHua Zhang
Nan Li
Xiang Hu
Xuetao Cao
Jing Jin
Chaofeng Han
Tianliang Li
Kewei Qin
P2860cites workAkt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylationQ24312168
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient miceQ24523182
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-bQ28506491
Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradationQ28512759
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectinsQ28588506
Mycobacteria target DC-SIGN to suppress dendritic cell functionQ28616857
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
The regulation of IL-10 production by immune cellsQ29615479
Recognition of microorganisms and activation of the immune responseQ29617903
Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10Q83181554
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritisQ30434426
E3 ubiquitin ligase Cbl-b in innate and adaptive immunityQ33953086
Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cellsQ35144129
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage functionQ35884586
CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiationQ36229469
Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells.Q36275547
Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance.Q36941065
Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppressionQ36983876
Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.Q37098840
The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell wallsQ37139051
The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applicationsQ37331097
Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis.Q37408857
The ins and outs of leukocyte integrin signalingQ37419383
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Comprehensive review: antitumor necrosis factor agents in inflammatory bowel disease and factors implicated in treatment responseQ38118313
Why interleukin-10 supplementation does not work in Crohn's disease patients.Q38120519
IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphismsQ38227341
Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis.Q38448841
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and diseaseQ38681728
A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammationQ38855496
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.Q39669362
Chemically induced mouse models of intestinal inflammationQ42510602
Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.Q44591687
Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.Q45718626
The history of Toll-like receptors - redefining innate immunity.Q46240771
Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammationQ46339677
A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cellsQ47810460
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.Q52956682
ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis.Q53003283
Characteristics of intestinal lamina propria dendritic cells in a mouse model of postinfectious irritable bowel syndrome.Q53201131
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.Q53587595
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.Q54600671
Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils.Q54709609
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitisQ57339877
Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activationQ58807981
Characteristics of Intestinal Dendritic Cells in Inflammatory Bowel DiseasesQ60175418
MyD88-dependent autoimmune disease in Lyn-deficient miceQ60444744
Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cellsQ61645726
Tumour necrosis factor alpha in stool as a marker of intestinal inflammationQ67512879
P2507corrigendum / erratumAuthor Correction: Integrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expressionQ101564272
P407language of work or nameEnglishQ1860
P304page(s)26252
P577publication date2016-05-18
P1433published inScientific ReportsQ2261792
P1476titleIntegrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expression
P478volume6

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cites work (P2860)
Q89689733Integrin CD11b Deficiency Aggravates Retinal Microglial Activation and RGCs Degeneration After Acute Optic Nerve Injury
Q54108748Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.
Q57039639[EXPRESS] CD11b activated Src signal attenuates neuroinflammatory pain by orchestrating inflammatory and anti-inflammatory cytokines in microglia

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