Evaluation of RevA, a fibronectin-binding protein of Borrelia burgdorferi, as a potential vaccine candidate for lyme disease

scientific article published on 17 April 2013

Evaluation of RevA, a fibronectin-binding protein of Borrelia burgdorferi, as a potential vaccine candidate for lyme disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/CVI.00758-12
P932PMC publication ID3675963
P698PubMed publication ID23595502
P5875ResearchGate publication ID236224804

P2093author name stringAngela M Floden
Robert A Gaultney
Tammy Gonzalez
Catherine A Brissette
P2860cites workGenomic sequence of a Lyme disease spirochaete, Borrelia burgdorferiQ22122357
Lyme DiseaseQ22250902
The Lyme vaccine: a cautionary taleQ22251377
Hidden in plain sight: Borrelia burgdorferi and the extracellular matrixQ22251447
Human pathogenic Borrelia spielmanii sp. nov. resists complement-mediated killing by direct binding of immune regulators factor H and factor H-like protein 1Q24672482
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferiQ27638660
A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferiQ28144621
Lyme borreliosisQ29013670
A monoclonal antibody generated by antigen inoculation via tick bite is reactive to the Borrelia burgdorferi Rev protein, a member of the 2.9 gene family locusQ32105929
Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouseQ33595436
The borrelial fibronectin-binding protein RevA is an early antigen of human Lyme diseaseQ33627104
Serum complement sensitivity as a key factor in Lyme disease ecology.Q33751851
Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferiQ33757680
Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversionQ33757693
Borrelia burgdorferi RevA antigen is a surface-exposed outer membrane protein whose expression is regulated in response to environmental temperature and pHQ34008806
Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infectionQ34031718
Approaches toward the directed design of a vaccine against Borrelia burgdorferiQ34543900
Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicityQ34681119
Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteinsQ34721407
Borrelia burgdorferi and its tropisms for adhesion molecules in the joint.Q34739476
Laboratory maintenance of Borrelia burgdorferiQ34821083
Temporal analysis of Borrelia burgdorferi Erp protein expression throughout the mammal-tick infectious cycleQ34945715
Adhesion mechanisms of the Lyme disease spirochete, Borrelia burgdorferiQ35010698
Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signalsQ35011172
'Nothing is permanent but change'- antigenic variation in persistent bacterial pathogensQ35968220
Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infectionQ36999798
Borrelia burgdorferi RevA antigen binds host fibronectinQ37256541
Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteinsQ37778852
Early and late cutaneous manifestations in Ixodes-borne borreliosis (erythema migrans borreliosis, Lyme borreliosis).Q39540066
Complement-mediated serum sensitivity among spirochetes that cause Lyme disease.Q39829393
A reverse transcriptase-polymerase chain reaction assay of Borrelia burgdorferi 16S rRNA for highly sensitive quantification of pathogen load in a vectorQ43220298
Dermatologic manifestations of Lyme diseaseQ44634069
Fibronectin-binding activity in Borrelia burgdorferi1.Q47760192
Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis.Q52591505
Multiplex PCR as a tool for validating plasmid content of Borrelia burgdorferi.Q54369916
The Spirochetal Etiology of Lyme DiseaseQ58402764
Inactivation of the fibronectin-binding adhesin genebbk32significantly attenuates the infectivity potential ofBorrelia burgdorferiQ62966001
Characterization of Borrelia burgdorferi associated antigens by monoclonal antibodiesQ67245001
Experimental Lyme arthritis in rats infected with Borrelia burgdorferiQ68091421
Etiology of the acrodermatitis chronica atrophicans lesion in Lyme diseaseQ71237076
Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosisQ72607871
Heterogeneity in the complement-dependent bacteriolysis within the species of Borrelia burgdorferiQ73313091
Insights from a novel three-dimensional in vitro model of lyme arthritis: standardized analysis of cellular and molecular interactions between Borrelia burgdorferi and synovial explants and fibroblastsQ73521683
Borrelia burgdorferi-specific monoclonal antibodies derived from mice primed with Lyme disease spirochete-infected Ixodes scapularis ticksQ74582507
The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogensQ80832075
Cultivation of Borrelia burgdorferi in dialysis membrane chambers in rat peritoneaQ81928321
Summary of notifiable diseases: United States, 2009Q84088142
Lyme borreliosisQ94329194
P433issue6
P921main subjectLyme diseaseQ201989
Borrelia burgdorferiQ2723634
P304page(s)892-899
P577publication date2013-04-17
P1433published inClinical and Vaccine ImmunologyQ5133811
P1476titleEvaluation of RevA, a fibronectin-binding protein of Borrelia burgdorferi, as a potential vaccine candidate for lyme disease
P478volume20

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cites work (P2860)
Q28533878BB0347, from the lyme disease spirochete Borrelia burgdorferi, is surface exposed and interacts with the CS1 heparin-binding domain of human fibronectin
Q35947418Borrelia burgdorferi RevA Significantly Affects Pathogenicity and Host Response in the Mouse Model of Lyme Disease
Q88310828Borrelia burgdorferi SpoVG DNA- and RNA-Binding Protein Modulates the Physiology of the Lyme Disease Spirochete
Q50334209Eliminating Factor H-Binding Activity of Borrelia burgdorferi CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine
Q92977211Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family
Q37695366That's my story, and I'm sticking to it--an update on B. burgdorferi adhesins
Q38414296The Borrelia burgdorferi CheY3 response regulator is essential for chemotaxis and completion of its natural infection cycle.
Q93034876The Lyme disease spirochete's BpuR DNA/RNA-binding protein is differentially expressed during the mammal-tick infectious cycle, which affects translation of the SodA superoxide dismutase
Q90050455The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
Q34747553The Western progression of lyme disease: infectious and Nonclonal Borrelia burgdorferi Sensu Lato populations in Grand Forks County, North Dakota