Proteolytic activation transforms heparin cofactor II into a host defense molecule

scientific article published on 8 May 2013

Proteolytic activation transforms heparin cofactor II into a host defense molecule is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1203030
P932PMC publication ID3677170
P698PubMed publication ID23656734
P5875ResearchGate publication ID236664938

P50authorMartin MalmstenQ58780071
Artur SchmidtchenQ88461456
Martina KalleQ114138745
P2093author name stringMatthias Mörgelin
Douglas M Tollefsen
Praveen Papareddy
Gopinath Kasetty
P2860cites workHistidine-rich glycoprotein protects from systemic Candida infectionQ24313429
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanismQ24534965
Heparin cofactor II inhibits arterial thrombosis after endothelial injuryQ24551168
Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3Q28117302
Antimicrobial peptides of multicellular organismsQ28131811
Pigment epithelium-derived factor: a potent inhibitor of angiogenesisQ28139159
Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular coagulationQ28205180
Protein C inhibitor--a novel antimicrobial agentQ28268083
Interaction of heparin cofactor II with neutrophil elastase and cathepsin GQ28280127
Proteolysis of human thrombin generates novel host defense peptidesQ29871443
Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytesQ33583259
C-terminal peptides of tissue factor pathway inhibitor are novel host defense moleculesQ34107512
Hormone binding globulins undergo serpin conformational change in inflammationQ34167746
Genetic control of blood pressure and the angiotensinogen locusQ34498129
Shape-shifting serpins--advantages of a mobile mechanismQ34544636
The contact system--a novel branch of innate immunity generating antibacterial peptidesQ35191114
Serpins in thrombosis, hemostasis and fibrinolysisQ36884340
The antipathogen activities of eosinophil cationic proteinQ37233059
Vascular Dermatan Sulfate and Heparin Cofactor IIQ37784316
Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?Q37807232
Lactoferrin a multiple bioactive protein: an overview.Q37897330
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Cationic host defence peptides: multifaceted role in immune modulation and inflammation.Q38022156
Maspin: molecular mechanisms and therapeutic implicationsQ38023237
A comparison of three heparin-binding serine proteinase inhibitorsQ38328907
Role of the proposed serpin-enzyme complex receptor recognition site in binding and internalization of thrombin-heparin cofactor II complexes by hepatocytesQ41176529
Innate immunity and coagulation.Q42856952
Heparin cofactor II activity in patients with disseminated intravascular coagulation and hepatic failureQ43911431
Ultrasensitive assays for endogenous antimicrobial polypeptidesQ45416239
Domain 5 of high molecular weight kininogen is antibacterialQ46642869
Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa.Q51642205
C1 inhibitor, a multi-functional serine protease inhibitorQ56772868
Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin–HCII complexQ57649373
Preferential consumption of heparin cofactor II in disseminated intravascular coagulation associated with acute promyelocytic leukemiaQ67564079
Heparin cofactor II-proteinase reaction products exhibit neutrophil chemoattractant activityQ69597083
Hereditary homozygous heparin cofactor II deficiency and the risk of developing venous thrombosisQ73013486
Degradation of antiproteinases, complement and fibronectin in chronic leg ulcersQ74211300
[Heparin cofactor II, a thrombin inhibitor with a still not clarified physiologic role]Q77814040
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
heparinQ190016
P304page(s)6303-6310
P577publication date2013-05-08
P1433published inJournal of ImmunologyQ3521441
P1476titleProteolytic activation transforms heparin cofactor II into a host defense molecule
P478volume190