Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide

scientific article published on 23 July 2008

Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BBRC.2008.07.061
P932PMC publication ID2556571
P698PubMed publication ID18655771
P5875ResearchGate publication ID51428961

P2093author name stringRaymond F Regan
Zhi Li
Jing Chen-Roetling
Xuefeng Zhang
Mai Chen
P2860cites workProteome analysis of human substantia nigra in Parkinson's diseaseQ21245637
Ferritin, iron homeostasis, and oxidative damageQ28216801
Ferritin: a cytoprotective antioxidant strategem of endotheliumQ28264360
Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasisQ28505771
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in miceQ28510424
Ferritin, iron homeostasis, and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.Q29399399
Iron in chronic brain disorders: imaging and neurotherapeutic implicationsQ31117154
Targeting mRNA to regulate iron and oxygen metabolismQ33800751
Regulation of ferritin genes and proteinQ34126332
The up-regulation of ferritin expression using a small-molecule ligand to the native mRNAQ34249780
A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brainsQ34300345
Excess capacity of the iron regulatory protein systemQ34644336
Iron misregulation in the brain: a primary cause of neurodegenerative disordersQ35172307
Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targetsQ36428733
Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobinQ36879524
Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA - (antioxidant response elements) and mRNA (iron responsive elements) sequencesQ38307919
Induction of ferritin expression by oxalomalateQ40562354
On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stabilityQ41056041
Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase.Q41438340
Lysosomal origin of the ferric iron required for cell killing by hydrogen peroxideQ41916319
Iron and iron-handling proteins in the brain after intracerebral hemorrhage.Q42452709
Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteinsQ42801891
Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicityQ44615955
Endogenous glutathione and catalase protect cultured rat astrocytes from the iron-mediated toxicity of hydrogen peroxide.Q44935958
Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic miceQ48275740
Neurotoxicity of hemoglobin in cortical cell cultureQ48300815
Increased body iron stores are associated with poor outcome after thrombolytic treatment in acute stroke.Q48351055
Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's diseaseQ48450930
Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction.Q54445792
Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitroQ70940537
Patterns of immunocytochemical staining for ferritin and transferrin in the human spinal cord following traumatic injuryQ74395795
Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stressQ77470748
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)6-10
P577publication date2008-07-23
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleIron regulatory proteins increase neuronal vulnerability to hydrogen peroxide
P478volume375

Reverse relations

cites work (P2860)
Q38796693Brain Iron Metabolism Dysfunction in Parkinson's Disease.
Q37145363Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2
Q89951766Deferoxamine deconditioning increases neuronal vulnerability to hemoglobin
Q33990386Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage
Q37436917Minocycline attenuates iron neurotoxicity in cortical cell cultures
Q36530600Oxidative stress increases HO-1 expression in ARPE-19 cells, but melanosomes suppress the increase when light is the stressor
Q37832421The many faces of the octahedral ferritin protein
Q39744987Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent