Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells

scientific article published on 06 June 2013

Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1017940876
P356DOI10.1186/1742-4690-10-60
P932PMC publication ID3681682
P698PubMed publication ID23742646
P5875ResearchGate publication ID237068984

P2093author name stringHaishan Li
C David Pauza
P2860cites workCritical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1-infected hu-PBL-NOD-SCID miceQ42944373
HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosisQ45143064
Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA.Q45853901
CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?Q59375800
Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patientsQ67755547
Abnormalities of B-Cell Activation and Immunoregulation in Patients with the Acquired Immunodeficiency SyndromeQ72790552
gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals: an immunoelectron microscopic studyQ73246042
Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T cell death that is facilitated by, but does not require cell-associated CD4Q80087943
Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteinsQ81889294
How much gp120 is there?Q83183629
The α4β7 integrin binds HIV envelope but does not mediate bystander killing of γδ T cellsQ84598272
Emerging concepts in the immunopathogenesis of AIDSQ22241984
Apoptosis of uninfected cells induced by HIV envelope glycoproteinsQ24801374
Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infectionQ28182419
Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosisQ28245953
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of diseaseQ28267375
The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosisQ28343812
Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronousQ28366094
Follicular helper CD4 T cells (TFH)Q29615063
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
T cell depletion in HIV-1 infection: how CD4+ T cells go out of stockQ34052457
Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissueQ34152017
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodesQ34297394
Influence of mitochondrial control of apoptosis on the pathogenesis, complications and treatment of HIV infectionQ34648909
HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDSQ35585948
Cytotoxic effect of HIV-1 gp120 on primary cultured human retinal capillary endothelial cells.Q35645059
Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolutionQ36048710
CD4 T follicular helper cell dynamics during SIV infectionQ36190736
Expansion of HIV-specific T follicular helper cells in chronic HIV infectionQ36190755
Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicityQ37360100
Pathogenic Mechanisms of HIV DiseaseQ37804860
Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes.Q39563512
Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposureQ40567871
Extensive apoptosis in lymphoid organs during primary SIV infection predicts rapid progression towards AIDS.Q40575730
Human Immunodeficiency Virus–Induced Apoptosis of Human Hepatocytes via CXCR4Q40615656
Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120).Q40895771
HIV-1 envelope glycoproteins-mediated apoptosis is regulated by CD4 dependent and independent mechanismsQ41135475
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P304page(s)60
P577publication date2013-06-06
P1433published inRetrovirologyQ15793508
P1476titleCritical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells
P478volume10

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cites work (P2860)
Q36742476CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo.
Q34944215CD25(+) Bcl6(low) T follicular helper cells provide help to maturing B cells in germinal centers of human tonsil
Q36085070Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection
Q40761860Expansion of myeloid-derived suppressor cells promotes differentiation of regulatory T cells in HIV-1+ individuals.
Q89535737Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network

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