Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).

scientific article published on 18 December 2007

Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/ARD.2007.077537
P932PMC publication ID2566534
P698PubMed publication ID18094002
P5875ResearchGate publication ID5755052

P2093author name stringShimizu S
Takeda A
Yoshimura A
Nakashima H
Yoshida H
Miyake K
Yoshimura T
Sugiyama N
Masutani K
Hamano S
Igawa T
Akahoshi M
Sadanaga A
P2860cites workCutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 CommitmentQ24301442
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27Q24307411
Cloning and characterization of a novel class I cytokine receptorQ24319055
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cellsQ28214882
Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosisQ28303824
Development of Th1-type immune responses requires the type I cytokine receptor TCCRQ28591931
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cellsQ34556912
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupusQ36403146
Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.Q40224822
Role of Fas-mediated cell death in the regulation of immune responsesQ41102922
IL-27 limits IL-2 production during Th1 differentiation.Q42676181
The pathogenesis of glomerulonephritisQ43449334
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine productionQ44721986
Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitisQ44788662
Toll-like receptor 9 signaling protects against murine lupusQ46872996
WSX-1: a key role in induction of chronic intestinal nematode infectionQ47371263
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionQ47388000
WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation.Q53674763
Murine models of systemic lupus erythematosusQ69894910
Predominance of Th1 immune response in diffuse proliferative lupus nephritisQ74602869
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infectionQ74840049
Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosusQ78124722
IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathwaysQ79370177
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous systemQ80102518
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunityQ80884527
Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient miceQ81009043
The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosisQ81482647
Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)Q81512203
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)1461-1467
P577publication date2007-12-18
P1433published inAnnals of the Rheumatic DiseasesQ4767876
P1476titleAmelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).
P478volume67

Reverse relations

cites work (P2860)
Q35031602An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
Q35227723Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.
Q45928071Decreased serum interleukin 27 in Brazilian systemic lupus erythematosus patients.
Q28072519Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity
Q42209377Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A.
Q39399282IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice
Q34325776IL-27 Regulates IL-18 binding protein in skin resident cells
Q48030835IL-27 is elevated in acute lung injury and mediates inflammation
Q34488727IL-27-induced modulation of autoimmunity and its therapeutic potential
Q37607910Interleukin 27: a double-edged sword for offense and defense
Q27022577Interleukin-27 in T cell immunity
Q26830400Interleukin-27: balancing protective and pathological immunity
Q42132106Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient
Q26822662Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus
Q42284538Overexpression of Epstein-Barr virus-induced gene 3 protein (EBI3) in MRL/lpr mice suppresses their lupus nephritis by activating regulatory T cells
Q37973328Regulatory T-cell-associated cytokines in systemic lupus erythematosus
Q37053851Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination
Q42702527Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
Q52608191T cell-specific overexpression of interleukin-27 receptor α subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice.
Q34463612TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses
Q34756202The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.
Q93158307The Immunobiology of the Interleukin-12 Family: Room for Discovery
Q30476952The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus
Q35294513The dysregulation of cytokine networks in systemic lupus erythematosus
Q37720703Therapeutic potential of IL-27 in systemic lupus erythematosus.
Q54119830Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice.
Q33895262WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells

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