The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis

scientific article published on 07 September 2007

The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1136/ARD.2007.074278
P932PMC publication ID2754165
P698PubMed publication ID17827184
P5875ResearchGate publication ID6013694

P2093author name stringG Schett
J Zwerina
G Firestein
P2860cites workMAP kinase phosphatasesQ21999790
Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognitionQ22009443
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathwaysQ24309037
A protein kinase involved in the regulation of inflammatory cytokine biosynthesisQ24311139
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiationQ24312012
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathwaysQ24313172
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)Q24321919
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinaseQ24336591
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42Q24532640
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.Q24537701
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factorQ24563111
c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activationQ24643842
Tumour necrosis factor activates the mitogen-activated protein kinases p38alpha and ERK in the synovial membrane in vivoQ24812465
Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblastsQ24816588
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1Q28114883
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritisQ28239856
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazolesQ28242608
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionQ28271470
Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expressionQ28281070
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathwayQ28306490
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1Q28366337
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient miceQ28509000
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2Q28509037
Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2Q28582470
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesisQ28593865
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38deltaQ28646538
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6Q28678886
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesQ29614338
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritisQ31071549
Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophilsQ33844346
A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKsQ33947411
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilizationQ34132949
A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formationQ34206534
The role of TNF alpha and IL-1 in rheumatoid arthritisQ34494501
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritisQ34600313
Osteoclasts are essential for TNF-alpha-mediated joint destructionQ34826003
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.Q35077234
Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritisQ35083265
Therapeutic strategies for rheumatoid arthritisQ35140855
Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritisQ35764588
CD44 is a determinant of inflammatory bone lossQ36403383
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteasesQ36564552
Mechanisms of Disease: the link between RANKL and arthritic bone diseaseQ36577375
Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathwaysQ38349161
Generation and characterization of p38beta (MAPK11) gene-targeted mice.Q39891313
Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritisQ40291953
Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinaseQ40310115
Molecular determinants that mediate selective activation of p38 MAP kinase isoformsQ40387373
Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclastsQ40634144
Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factorQ40838540
p38 mitogen-activated protein kinase is involved in Fas ligand expression.Q40932801
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinaseQ41091097
Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.Q41159649
Mitogen-activated protein kinase cascades and the signaling of hyperosmotic stress to immediate early genesQ41489240
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosisQ42093335
Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells.Q42451113
Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cellsQ42506355
Activated Ras modifies the proliferative response of rheumatoid synovial cells to TNF-alpha and TGF-alphaQ42516692
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)Q42609308
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expressionQ42640386
Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages.Q42820899
p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast functionQ44072080
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytesQ44523741
Benzimidazolone p38 inhibitorsQ44794274
The development of novel inhibitors of tumor necrosis factor-alpha (TNF-alpha) production based on substituted [5,5]-bicyclic pyrazolonesQ44984428
Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoidsQ45099909
Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathologyQ45099938
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinaseQ45164329
The SCID mouse--a novel experimental model for gene therapy in human rheumatoid arthritisQ45865451
Expression of hypoxia-inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed jointQ45878755
Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinaseQ47954457
The stathmin/tubulin interaction in vitroQ48622434
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cellsQ50336697
Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha-induced vascular permeability.Q50503690
Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1.Q53663061
P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional LevelQ57243702
Oncoprotein expression in human synovial tissue: an immunohistochemical study of different types of arthritisQ60375192
RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinaseQ73091494
Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthrQ73202432
The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblastsQ73323617
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritisQ73374754
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653Q73401323
Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasionQ73661500
p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulationQ74196042
Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinaseQ77229202
Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineagesQ77320464
Purification and activation of recombinant p38 isoforms alpha, beta, gamma, and deltaQ77471905
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cellsQ77911866
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritisQ79929670
Signal transduction in rheumatoid arthritisQ79971761
Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destructionQ82424436
A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritisQ83101988
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
mitogen-activated protein kinase p38 bindingQ21119245
P304page(s)909-916
P577publication date2007-09-07
P1433published inAnnals of the Rheumatic DiseasesQ4767876
P1476titleThe p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis
P478volume67

Reverse relations

cites work (P2860)
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