review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | G Schett | |
J Zwerina | |||
G Firestein | |||
P2860 | cites work | MAP kinase phosphatases | Q21999790 |
Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition | Q22009443 | ||
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways | Q24309037 | ||
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis | Q24311139 | ||
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation | Q24312012 | ||
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways | Q24313172 | ||
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta) | Q24321919 | ||
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase | Q24336591 | ||
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42 | Q24532640 | ||
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. | Q24537701 | ||
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor | Q24563111 | ||
c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation | Q24643842 | ||
Tumour necrosis factor activates the mitogen-activated protein kinases p38alpha and ERK in the synovial membrane in vivo | Q24812465 | ||
Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts | Q24816588 | ||
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 | Q28114883 | ||
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis | Q28239856 | ||
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles | Q28242608 | ||
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction | Q28271470 | ||
Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression | Q28281070 | ||
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway | Q28306490 | ||
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1 | Q28366337 | ||
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice | Q28509000 | ||
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2 | Q28509037 | ||
Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2 | Q28582470 | ||
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis | Q28593865 | ||
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta | Q28646538 | ||
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6 | Q28678886 | ||
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases | Q29614338 | ||
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis | Q31071549 | ||
Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils | Q33844346 | ||
A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs | Q33947411 | ||
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization | Q34132949 | ||
A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation | Q34206534 | ||
The role of TNF alpha and IL-1 in rheumatoid arthritis | Q34494501 | ||
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis | Q34600313 | ||
Osteoclasts are essential for TNF-alpha-mediated joint destruction | Q34826003 | ||
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. | Q35077234 | ||
Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis | Q35083265 | ||
Therapeutic strategies for rheumatoid arthritis | Q35140855 | ||
Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis | Q35764588 | ||
CD44 is a determinant of inflammatory bone loss | Q36403383 | ||
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases | Q36564552 | ||
Mechanisms of Disease: the link between RANKL and arthritic bone disease | Q36577375 | ||
Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways | Q38349161 | ||
Generation and characterization of p38beta (MAPK11) gene-targeted mice. | Q39891313 | ||
Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis | Q40291953 | ||
Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase | Q40310115 | ||
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms | Q40387373 | ||
Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts | Q40634144 | ||
Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor | Q40838540 | ||
p38 mitogen-activated protein kinase is involved in Fas ligand expression. | Q40932801 | ||
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase | Q41091097 | ||
Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2. | Q41159649 | ||
Mitogen-activated protein kinase cascades and the signaling of hyperosmotic stress to immediate early genes | Q41489240 | ||
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis | Q42093335 | ||
Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells. | Q42451113 | ||
Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cells | Q42506355 | ||
Activated Ras modifies the proliferative response of rheumatoid synovial cells to TNF-alpha and TGF-alpha | Q42516692 | ||
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38) | Q42609308 | ||
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression | Q42640386 | ||
Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages. | Q42820899 | ||
p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function | Q44072080 | ||
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes | Q44523741 | ||
Benzimidazolone p38 inhibitors | Q44794274 | ||
The development of novel inhibitors of tumor necrosis factor-alpha (TNF-alpha) production based on substituted [5,5]-bicyclic pyrazolones | Q44984428 | ||
Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids | Q45099909 | ||
Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathology | Q45099938 | ||
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase | Q45164329 | ||
The SCID mouse--a novel experimental model for gene therapy in human rheumatoid arthritis | Q45865451 | ||
Expression of hypoxia-inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint | Q45878755 | ||
Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase | Q47954457 | ||
The stathmin/tubulin interaction in vitro | Q48622434 | ||
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells | Q50336697 | ||
Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha-induced vascular permeability. | Q50503690 | ||
Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. | Q53663061 | ||
P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional Level | Q57243702 | ||
Oncoprotein expression in human synovial tissue: an immunohistochemical study of different types of arthritis | Q60375192 | ||
RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase | Q73091494 | ||
Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthr | Q73202432 | ||
The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts | Q73323617 | ||
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis | Q73374754 | ||
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653 | Q73401323 | ||
Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion | Q73661500 | ||
p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation | Q74196042 | ||
Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase | Q77229202 | ||
Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages | Q77320464 | ||
Purification and activation of recombinant p38 isoforms alpha, beta, gamma, and delta | Q77471905 | ||
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells | Q77911866 | ||
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis | Q79929670 | ||
Signal transduction in rheumatoid arthritis | Q79971761 | ||
Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction | Q82424436 | ||
A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis | Q83101988 | ||
P433 | issue | 7 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | rheumatoid arthritis | Q187255 |
mitogen-activated protein kinase p38 binding | Q21119245 | ||
P304 | page(s) | 909-916 | |
P577 | publication date | 2007-09-07 | |
P1433 | published in | Annals of the Rheumatic Diseases | Q4767876 |
P1476 | title | The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis | |
P478 | volume | 67 |
Q37649076 | "Go upstream, young man": lessons learned from the p38 saga |
Q47109368 | A Central Bioactive Region of LTBP-2 Stimulates the Expression of TGF-β1 in Fibroblasts via Akt and p38 Signalling Pathways |
Q58751480 | A frog cathelicidin peptide effectively promotes cutaneous wound healing in mice |
Q40840109 | A multitude of kinases--which are the best targets in treating rheumatoid arthritis? |
Q33576200 | A potential wound-healing-promoting peptide from salamander skin |
Q34067264 | Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. |
Q21131225 | An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity |
Q36096147 | Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6 |
Q90101187 | Apixaban exhibits anti-arthritic effects by inhibiting activated factor X-mediated JAK2/STAT3 and MAPK phosphorylation pathways |
Q34103531 | Autoantibodies against the catalytic domain of BRAF are not specific serum markers for rheumatoid arthritis |
Q60628150 | C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10 |
Q39002838 | Cell Signaling Pathways That Regulate Antigen Presentation |
Q38129724 | Cell-signaling therapy in rheumatoid arthritis |
Q33811207 | Chiral kinase inhibitors |
Q33923272 | Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis |
Q35705460 | Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice |
Q37581863 | Development of extracellular signal-regulated kinase inhibitors. |
Q42429559 | Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes |
Q43680539 | Differential roles of JNK, ERK1/2, and p38 mitogen-activated protein kinases on endothelial cell tissue repair functions in response to tumor necrosis factor-α. |
Q37418631 | Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study. |
Q39508065 | Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors |
Q39736497 | Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors |
Q47379129 | Effect of nobiletin on the MAPK/NF-κB signaling pathway in the synovial membrane of rats with arthritis induced by collagen |
Q37763192 | Emerging drugs for psoriatic arthritis. |
Q38182971 | Emerging role of endosomal toll-like receptors in rheumatoid arthritis |
Q37020591 | Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome |
Q24598633 | Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis |
Q52608167 | Flavonoid quercetin-methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis. |
Q64235378 | Flemingia philippinensis Flavonoids Relieve Bone Erosion and Inflammatory Mediators in CIA Mice by Downregulating NF-B and MAPK Pathways |
Q37688086 | Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses |
Q34076975 | Genome-wide gene and pathway analysis. |
Q52632432 | Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis. |
Q42044465 | ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes |
Q42081434 | Identification of dysregulated genes in rheumatoid arthritis based on bioinformatics analysis |
Q88933245 | Identification of key genes in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis |
Q91900926 | Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes |
Q47232180 | Immunosuppressive Effect of Geniposide on Mitogen-Activated Protein Kinase Signalling Pathway and Their Cross-Talk in Fibroblast-Like Synoviocytes of Adjuvant Arthritis Rats. |
Q41889582 | Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway |
Q48821093 | Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes-mediated synovial inflammation and joint destruction in rheumatoid arthritis |
Q64986074 | Inhibition of Osteoclastogenesis by Thioredoxin-Interacting Protein-Derived Peptide (TN13). |
Q42500459 | Inhibition of p38 pathway leads to OA-like changes in a rat animal model |
Q47329677 | Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation. |
Q34551138 | Intracellular signal pathways: potential for therapies. |
Q38323383 | Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease |
Q34276089 | JAK inhibition for the treatment of rheumatoid arthritis: a new era in oral DMARD therapy |
Q38413562 | Juglone ameliorates skin wound healing by promoting skin cell migration through Rac1/Cdc42/PAK pathway |
Q37237647 | Keratinocytes express cytokines and nerve growth factor in response to neuropeptide activation of the ERK1/2 and JNK MAPK transcription pathways |
Q40173296 | Kinetic analysis of synovial signalling and gene expression in animal models of arthritis |
Q33562738 | Korean red ginseng saponin fraction rich in ginsenoside-Rb1, Rc and Rb2 attenuates the severity of mouse collagen-induced arthritis |
Q35775909 | Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1β-induced arthritis |
Q37033102 | Long-range regulatory synergy is required to allow control of the TAC1 locus by MEK/ERK signalling in sensory neurones |
Q42384664 | Losmapimod does not reduce cardiovascular events in patients with acute myocardial infarction |
Q37855881 | Low-molecular-weight MK2 inhibitors: a tough nut to crack! |
Q35047271 | Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma |
Q50736383 | Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine. |
Q92647957 | P38 MAPK signaling pathway mediates COM crystal-induced crystal adhesion change in rat renal tubular epithelial cells |
Q92636977 | Peficitinib Inhibits the Chemotactic Activity of Monocytes via Proinflammatory Cytokine Production in Rheumatoid Arthritis Fibroblast-Like Synoviocytes |
Q37113415 | Post-transcriptional control of cytokine production |
Q42272947 | Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study |
Q92078915 | RA-map: building a state-of-the-art interactive knowledge base for rheumatoid arthritis |
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Q35751545 | Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well |
Q45923771 | Signal pathways regulating hyaluronan secretion into static and cycled synovial joints of rabbits. |
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Q57422855 | Smoking and polymorphisms of genes encoding mannose-binding lectin and surfactant protein-D in patients with rheumatoid arthritis |
Q97519111 | Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling |
Q91163336 | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 2 |
Q92841691 | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1 |
Q33504871 | Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice |
Q43061922 | Synthesis and biological testing of N-aminoimidazole-based p38alpha MAP kinase inhibitors. |
Q34868949 | The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid |
Q35739675 | The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes |
Q52726758 | The Efficacy and Underlying Mechanism of Moxibustion in Preventing Cognitive Impairment: A Systematic Review of Animal Studies. |
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Q34713116 | The shared crosstalk of multiple pathways involved in the inflammation between rheumatoid arthritis and coronary artery disease based on a digital gene expression profile |
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