Generation and characterization of p38beta (MAPK11) gene-targeted mice.

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Generation and characterization of p38beta (MAPK11) gene-targeted mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.25.23.10454-10464.2005
P8608Fatcat IDrelease_v2sawrzthfg2niocxyfzyvrb7i
P932PMC publication ID1291241
P698PubMed publication ID16287858

P50authorGiorgos KolliasQ11260534
Simon J. ArthurQ46843760
Marietta ArmakaQ49464153
P2093author name stringLaura J Armit
Victoria A Beardmore
Heather J Hinton
Carol Clacher
Julia M Carr
Maria Apostolaki
Christina Eftychi
Joanne Darragh
Joanne McIlrath
Loraine Malone
P2860cites workInduction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathwaysQ24309037
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREBQ24319704
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3Q24320233
The protein kinase complement of the human genomeQ24324497
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblastsQ24537233
p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAPQ24555714
Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivoQ36375760
Feedback control of the protein kinase TAK1 by SAPK2a/p38Q40240134
Molecular determinants that mediate selective activation of p38 MAP kinase isoformsQ40387373
MAPK p38 alpha is dispensable for lymphocyte development and proliferation.Q40468334
MSK1 activity is controlled by multiple phosphorylation sites.Q40487132
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutationQ40561467
Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanismsQ40971614
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosisQ42093335
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitutionQ42541263
MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.Q42953889
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocketQ47982160
Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase.Q52519672
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.Q52547825
Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich ElementsQ62819809
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular developmentQ74191149
Effect of SB 203580 on the activity of c-Raf in vitro and in vivoQ77733964
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificityQ27641774
MAPK-regulated transcription: a continuously variable gene switch?Q28217211
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionQ28271470
Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cellsQ28343994
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesisQ28505039
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expressionQ28507834
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient miceQ28509000
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2Q28509037
Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascadesQ28566826
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levelsQ28586348
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesisQ28593865
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesisQ28594675
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6Q28678886
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesQ29614338
On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel diseaseQ33333935
The p38 signal transduction pathway: activation and functionQ33838955
p38 MAP kinases: beyond the stress responseQ33934138
Inhibition of p38 MAP kinase as a therapeutic strategyQ33957191
Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.Q34081023
MAP-kinase signaling pathways in T cellsQ34282347
Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elementsQ34364003
Activation and signaling of the p38 MAP kinase pathwayQ34390191
Identification and characterization of a predominant isoform of human MKK3.Q34416895
MAP kinases in the immune responseQ34542231
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.Q34787933
Mixed-lineage kinase control of JNK and p38 MAPK pathwaysQ34810173
In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistanceQ35009282
PI3K-signalling in B- and T-cells: insights from gene-targeted miceQ35053089
Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis.Q35165967
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseasesQ35209995
The p38 MAP kinase pathway as a therapeutic target in inflammatory diseaseQ35834912
Modeling the function of tumor necrosis factor in immune pathophysiologyQ35862356
Mechanism of p38 MAP kinase activation in vivo.Q35967224
New therapies for rheumatoid arthritisQ36088346
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)10454-10464
P577publication date2005-12-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleGeneration and characterization of p38beta (MAPK11) gene-targeted mice
P478volume25

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cites work (P2860)
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Q36469025SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3' untranslated region in macrophages independently of its effect on p38 MAPK activity
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Q38260028p38δ MAPK: Emerging Roles of a Neglected Isoform

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