AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

scientific article published on 27 May 2016

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP26758
P8608Fatcat IDrelease_orrudcdhy5ew5g7nbf7326ufli
P932PMC publication ID4882625
P698PubMed publication ID27230293

P50authorValérie VingtdeuxQ30421269
Luc BuéeQ56526742
Benoit ViolletQ42482187
Peter DaviesQ42689763
P2093author name stringPhilippe Marambaud
Haitian Zhao
Pallavi Chandakkar
Claudia Marinangeli
Sébastien Didier
Manon Domise
P2860cites workPhosphorylation of microtubule-associated protein tau by AMPK-related kinasesQ24292882
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruptionQ24313701
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivityQ24554361
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cellsQ24655644
Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's DiseaseQ26801929
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse modelQ28115206
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegenerationQ28140796
Metabolic regulation of neuronal plasticity by the energy sensor AMPKQ28472728
The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer diseaseQ28583038
Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous systemQ28587570
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficitsQ30478477
Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD.Q30984127
Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes.Q33418581
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.Q33726605
Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β.Q34123865
Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesisQ34296550
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signalingQ34411340
AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathiesQ34696305
Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse modelsQ35053059
Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's diseaseQ35130191
Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's diseaseQ35223831
Tau phosphorylation at serine 396 residue is required for hippocampal LTDQ35316005
AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.Q54622561
Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domainQ60603639
Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5Q60603655
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tauQ67894826
Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transportsQ73266498
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenesQ73716600
Neither LKB1 nor AMPK are the direct targets of metforminQ80212438
Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 PhosphorylationQ35905362
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitorsQ36067364
Sensitive quantitative assays for tau and phospho-tau in transgenic mouse modelsQ36328476
Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neuritesQ36604979
Methods for measuring tau pathology in transgenic mouse modelsQ36768791
Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in strokeQ37087368
The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylationQ37200468
Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.Q37780209
Multiple Defects in Energy Metabolism in Alzheimers DiseaseQ37788708
Function of the master energy regulator adenosine monophosphate-activated protein kinase in strokeQ38086798
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neuronsQ38342193
Glucose regulates amyloid β production via AMPK.Q38864538
The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3betaQ40097597
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.Q40223208
Pin1 allows for differential Tau dephosphorylation in neuronal cellsQ40280535
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.Q41423732
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like stateQ41525580
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.Q42654706
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubulesQ43273610
Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1.Q43759003
AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivationQ43772807
Mitotic-like tau phosphorylation by p25-Cdk5 kinase complexQ44491452
Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament TauQ46127208
cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.Q48128979
Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.Q48166125
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)26758
P577publication date2016-05-27
P1433published inScientific ReportsQ2261792
P1476titleAMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
P478volume6

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cites work (P2860)
Q60950124AMP-activated Protein Kinase Controls Immediate Early Genes Expression Following Synaptic Activation Through the PKA/CREB Pathway
Q90599555AMPK Signaling Regulates the Age-Related Decline of Hippocampal Neurogenesis
Q38998405AMPK in Neurodegenerative Diseases
Q92970102Adiponectin Protects Against Cerebral Ischemic Injury Through AdipoR1/AMPK Pathways
Q90432920Adiponectin and Cognitive Decline
Q47132179An AMPK-dependent regulatory pathway in tau-mediated toxicity.
Q91542980Autophagy induction in the treatment of Alzheimer's disease
Q91629943Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks
Q99578886Circuitry and Synaptic Dysfunction in Alzheimer's Disease: A New Tau Hypothesis
Q38741861Current and future therapies for addressing the effects of inflammation on HDL cholesterol metabolism
Q39316849Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis
Q59791740Loss of Ca/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease
Q90094424Metabolic aspects of neuronal degeneration: From a NAD+ point of view
Q64066919Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process
Q33770234Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease.
Q91291806Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
Q91644474Prospective of managing impaired brain insulin signalling in late onset Alzheimers disease with excisting diabetic drugs
Q90288934Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease
Q89411641Recent Insights on Alzheimer's Disease Originating from Yeast Models
Q90252848Research Progress on Alzheimer's Disease and Resveratrol
Q90152657The Bewildering Effect of AMPK Activators in Alzheimer's Disease: Review of the Current Evidence
Q92993163mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival

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