Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses.

scientific article published on 23 May 2016

Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/V8050139
P932PMC publication ID4885094
P698PubMed publication ID27223301

P50authorMaría Fernanda PascuttiQ55136512
María Paula Del Médico ZajacQ57782014
Juliana FaliveneQ89280974
Andrea BruttomessoQ89280976
Maria Belen VecchioneQ41160868
P2093author name stringGabriela Calamante
Cynthia Maeto
María Magdalena Gherardi
María Pía Holgado
Micaela Amigo
P2860cites workGeneration of CD8 T cell memory is regulated by IL-12.Q51973127
Steroid hormone synthesis by a vaccinia enzyme: a new type of virus virulence factor.Q54381288
Preparation of cell cultures and vaccinia virus stocks.Q55076619
Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccineQ57569666
The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism (author's transl)Q66849845
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulationQ79213173
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factorsQ24303448
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South AfricaQ24647137
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiationQ24649009
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cellsQ24651232
Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-CQ27306437
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
Host-reactive CD8+ memory stem cells in graft-versus-host diseaseQ28281894
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasomeQ28389050
Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in miceQ30973875
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccinesQ33210436
Extended follow-up following a phase 2b randomized trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in KenyaQ33294698
Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA).Q33320536
The envelope protein encoded by the A33R gene is required for formation of actin-containing microvilli and efficient cell-to-cell spread of vaccinia virusQ33782803
The vaccinia virus superoxide dismutase-like protein (A45R) is a virion component that is nonessential for virus replication.Q33844429
Novel mucosal DNA-MVA HIV vaccination in which DNA-IL-12 plus cholera toxin B subunit (CTB) cooperates to enhance cellular systemic and mucosal genital tract immunityQ34172564
Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding proteinQ34182371
IL-12 and GM-CSF in DNA/MVA immunizations against HIV-1 CRF12_BF Nef induced T-cell responses with an enhanced magnitude, breadth and qualityQ34289072
Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigensQ34465228
The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxvirusesQ34469355
Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses.Q34594898
Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling PathwaysQ34796206
Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles.Q34991112
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.Q35150010
Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathwayQ35151746
The biology of IL-12: coordinating innate and adaptive immune responsesQ35209127
Interleukin-1- and type I interferon-dependent enhanced immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletions of type I and type II interferon-binding proteinsQ35488175
Vaccinia vectors as candidate vaccines: the development of modified vaccinia virus Ankara for antigen deliveryQ35551800
Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-betaQ35615827
Deletion of Fifteen Open Reading Frames from Modified Vaccinia Virus Ankara Fails to Improve ImmunogenicityQ35656345
Modified vaccinia Ankara: potential as an alternative smallpox vaccineQ35823036
Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infectionQ36370370
Antiviral innate immunity pathways.Q36394971
Deletion of specific immune-modulatory genes from modified vaccinia virus Ankara-based HIV vaccines engenders improved immunogenicity in rhesus macaquesQ36397581
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulenceQ36403362
IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cellsQ36694205
CD8+ T cell efficacy in vaccination and diseaseQ37184070
Clinical development of MVA-based therapeutic cancer vaccinesQ37259579
Innate immunity to virus infection.Q37361448
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.Q37421291
Deletion of the vaccinia virus N2L gene encoding an inhibitor of IRF3 improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens.Q37643731
Prime-boost vectored malaria vaccines: progress and prospectsQ37671502
MVA-85A, a novel candidate booster vaccine for the prevention of tuberculosis in children and adults.Q37689057
TroVax, a recombinant modified vaccinia Ankara virus encoding 5T4: Lessons learned and future developmentQ37803061
Regulation of effector and memory T-cell functions by type I interferonQ37841676
Clinical development of Modified Vaccinia virus Ankara vaccinesQ38092470
Clinical applications of attenuated MVA poxvirus strain.Q38156198
Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size.Q39074830
One-step simple assay to determine antigen-specific cytotoxic activities by single-color flow cytometryQ39546386
Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccineQ39589039
Characterization of DNA and MVA vectors expressing Nef from HIV-1 CRF12_BF revealed high immune specificity with low cross-reactivity against subtype B.Q39806689
Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus AnkaraQ40506182
Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlatesQ40779546
Effect of 3-beta-hydroxysteroid dehydrogenase gene deletion on virulence and immunogenicity of different vaccinia viruses and their recombinants.Q41012022
Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccineQ41039759
Highly attenuated modified vaccinia virus Ankara replicates in baby hamster kidney cells, a potential host for virus propagation, but not in various human transformed and primary cellsQ41064284
Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell lineQ41076591
A constitutively expressed vaccinia gene encodes a 42-kDa glycoprotein related to complement control factors that forms part of the extracellular virus envelopeQ42610963
Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus AnkaraQ42637410
Poxvirus vectorsQ44509221
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodesQ44639419
Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansionQ45373249
Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.Q45421530
Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routesQ45731710
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectVaccinia virusQ1986297
vector-borne diseaseQ2083837
P577publication date2016-05-23
P1433published inVirusesQ7935305
P1476titleDeletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses
P478volume8

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cites work (P2860)
Q47549689CRISPR/Cas9-Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development
Q47552501Characterizing the effects of insertion of a 5.2 kb region of a VACV genome, which contains known immune evasion genes, on MVA immunogenicity
Q89633807Deletion of Vaccinia Virus A40R Gene Improves the Immunogenicity of the HIV-1 Vaccine Candidate MVA-B
Q45325213Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?
Q47252143Immune Modulation of NYVAC-Based HIV Vaccines by Combined Deletion of Viral Genes that Act on Several Signalling Pathways
Q60913456Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics