Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)

scientific article published on April 30, 2013

Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.473009
P953full work available online athttp://www.jbc.org/article/S0021925820457977/pdf
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https://api.elsevier.com/content/article/PII:S0021925820457977?httpAccept=text/xml
https://doi.org/10.1074/jbc.m113.473009
https://europepmc.org/articles/PMC3689950
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https://syndication.highwire.org/content/doi/10.1074/jbc.M113.473009
P932PMC publication ID3689950
P698PubMed publication ID23632075

P2093author name stringHyun Kim
Johannes H. Reithinger
Ji Eun Hani Kim
P2860cites workMammalian Sec61 is associated with Sec62 and Sec63Q22254037
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membraneQ27932673
Ssh1p Determines the Translocation and Dislocation Capacities of the Yeast Endoplasmic ReticulumQ27936816
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2pQ27937164
Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulumQ27937605
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphataseQ27938078
SignalP 4.0: discriminating signal peptides from transmembrane regionsQ29547202
Evidence for the loop model of signal-sequence insertion into the endoplasmic reticulumQ33655044
Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humansQ33689768
Recombination-mediated PCR-directed plasmid construction in vivo in yeastQ34624355
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranesQ34719604
The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signalQ34741147
Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulumQ34785303
Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathwayQ34987145
Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomesQ35155249
Molecular mechanism of signal sequence orientation in the endoplasmic reticulumQ35160351
Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon ComplexQ35235093
Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocationQ36091833
Signal sequences specify the targeting route to the endoplasmic reticulum membraneQ36236983
Multiple determinants direct the orientation of signal-anchor proteins: the topogenic role of the hydrophobic signal domainQ36274131
Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulumQ36358019
Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal chargeQ36752567
Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helicesQ36949128
Sec62p, a component of the endoplasmic reticulum protein translocation machinery, contains multiple binding sites for the Sec-complexQ38489953
Heads or tails — what determines the orientation of proteins in the membraneQ40463759
Combined chemical and genetic approach to inhibit proteolysis by the proteasome.Q42972067
Glycosylatable GFP as a compartment-specific membrane topology reporterQ44897208
Molecular code for transmembrane-helix recognition by the Sec61 transloconQ46853934
The role of the hydrophobic domain in orienting natural signal sequences within the ER membraneQ47952437
Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthensQ52842432
Signal sequence recognition in posttranslational protein transport across the yeast ER membraneQ53945518
Orientation of Internal Signal-Anchor Sequences at the Sec61 TransloconQ56775230
The Topogenic Contribution of Uncharged Amino Acids on Signal Sequence Orientation in the Endoplasmic ReticulumQ56775266
The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domainQ74175787
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
hydrophobicityQ41854968
P304page(s)18058-18067
P577publication date2013-04-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleSec62 protein mediates membrane insertion and orientation of moderately hydrophobic signal anchor proteins in the endoplasmic reticulum (ER)
Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)
P478volume288

Reverse relations

cites work (P2860)
Q57381452A short C-terminal tail prevents mis-targeting of hydrophobic mitochondrial membrane proteins to the ER
Q47096501An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases.
Q54964955Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.
Q35470364Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events
Q64244254Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis
Q92651089Functions and Mechanisms of the Human Ribosome-Translocon Complex
Q36110851Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions
Q47228430Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents.
Q36640322Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma.
Q42129207Mammalian Prion protein expression in yeast; a model for transmembrane insertion
Q38682991Refined topology model of the STT3/Stt3 protein subunit of the oligosaccharyltransferase complex
Q28542401Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation
Q34076055Structural and functional profiling of the lateral gate of the Sec61 translocon
Q92701031The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
Q38206834The Sec translocon mediated protein transport in prokaryotes and eukaryotes.
Q42842073The Sec63p J-domain is required for ERAD of soluble proteins in yeast
Q34428674Type II transmembrane domain hydrophobicity dictates the cotranslational dependence for inversion.

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