Pericytes: gatekeepers in tumour cell metastasis?

scientific article published on 22 September 2007

Pericytes: gatekeepers in tumour cell metastasis? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1007/S00109-007-0258-2
P698PubMed publication ID17891366
P5875ResearchGate publication ID5953602

P50authorHolger GerhardtQ38800803
Henrik SembQ51626453
P2093author name stringHolger Gerhardt
Henrik Semb
P2860cites workInvolvement of chemokine receptors in breast cancer metastasisQ24290909
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesisQ24313372
The Hallmarks of CancerQ221226
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasisQ57382204
Magnetic Resonance Visualization of Tumor Angiogenesis by Targeting Neural Cell Adhesion Molecules with the Highly Sensitive Gadolinium-Loaded Apoferritin ProbeQ58831586
Neural Cell Adhesion Molecule-Deficient β-Cell Tumorigenesis Results in Diminished Extracellular Matrix Molecule Expression and Tumour Cell-Matrix AdhesionQ64018872
Neural cell adhesion molecule (N-CAM) in gastrointestinal neoplasiasQ73311077
Expression of neural cell adhesion molecule in pancreatic cancerQ73615776
Tumor suppressor activity of neural cell adhesion molecule in colon carcinomaQ73766659
Lymphangiogenesis and tumor metastasisQ79092311
Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinomaQ80917841
Therapeutic targeting of the tumor microenvironmentQ81839382
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesisQ24669710
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitorsQ24676378
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesisQ24681191
Openings between defective endothelial cells explain tumor vessel leakinessQ24681507
The role of pericytes in blood-vessel formation and maintenanceQ24683881
Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell developmentQ24806905
NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesisQ28509922
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and MetastasisQ29396371
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
A molecular signature of metastasis in primary solid tumorsQ29614442
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient MiceQ29615196
Molecular regulation of angiogenesis and lymphangiogenesisQ29616150
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumorsQ29617042
High interstitial fluid pressure - an obstacle in cancer therapyQ29619719
Endothelial/pericyte interactionsQ29619802
Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulating NCAM surface expressionQ33267205
An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculatureQ33751487
Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturationQ33771400
Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathwayQ33896998
Endothelial-pericyte interactions in angiogenesis.Q34217484
Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.Q34309108
Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy.Q34343317
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasisQ34359534
Early contribution of pericytes to angiogenic sprouting and tube formationQ34367285
Lymphatic vessels in cancer metastasis: bridging the gapsQ34511039
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitmentQ34527775
Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?Q34600828
Molecular mechanisms of lymphangiogenesis in health and diseaseQ34710547
Molecular control of arterial-venous blood vessel identityQ35066914
PDGF receptors as cancer drug targetsQ35142965
Angiogenesis, lymphangiogenesis, and melanoma metastasisQ35146591
Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?Q35167412
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signalingQ35649971
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumorsQ35788785
Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells.Q35791370
Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitmentQ35849918
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wallQ35967045
Role of pericytes in vascular morphogenesis.Q35992869
Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasisQ36012194
Cellular abnormalities of blood vessels as targets in cancerQ36015542
Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.Q36251988
Pericytes and vascular stabilityQ36319680
Lymphangiogenesis in development and human diseaseQ36342355
Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases.Q36365791
Lessons from phase III clinical trials on anti-VEGF therapy for cancerQ36366446
Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agentsQ36504945
Predicting benefit from anti-angiogenic agents in malignancyQ36534760
Genetic determinants of cancer metastasisQ36794312
Molecular mechanisms of lymphatic vascular developmentQ36801434
Hypoxia and prognosis: the oxygen tension mountsQ36813772
Loss of heterozygosity on chromosome 11 q in breast cancerQ37261791
Levels of angiogenesis and expression of angiogenesis-related genes are prognostic for organ-specific metastasis of renal cell carcinomaQ38444129
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.Q39740070
Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumorsQ39961300
Neural-cell adhesion molecule (NCAM) expression by immature and tumor-derived endothelial cells favors cell organization into capillary-like structuresQ40331718
Angiopoietin 1, PDGF-B, and TGF-beta gene regulation in endothelial cell and smooth muscle cell interactionQ40593666
Expression level of neural cell adhesion molecule (NCAM) inversely correlates with the ability of neuroblastoma cells to adhere to endothelium in vitroQ40678537
Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF.Q40718604
Pericytes limit tumor cell metastasisQ41916240
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assemblyQ42168707
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular developmentQ42276166
N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chickenQ42490043
Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturationQ42806733
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanismsQ43540251
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumorsQ43578049
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapyQ44164588
Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapyQ46469087
Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticityQ46744195
Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytesQ48483961
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.Q52529779
Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.Q53425388
P433issue2
P921main subjectpericyteQ500446
P304page(s)135-144
P577publication date2007-09-22
P1433published inJournal of Molecular MedicineQ6295593
P1476titlePericytes: gatekeepers in tumour cell metastasis?
P478volume86

Reverse relations

cites work (P2860)
Q35015782Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection
Q36637584Adult mesenchymal stem cells and the NO pathways
Q26862741Anti-angiogenesis and metastasis: a tumour and stromal cell alliance
Q35205410Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches.
Q37883011Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
Q30489784Characterization of vascular mural cells during zebrafish development
Q36627144Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis
Q37254877DLK1: a novel target for immunotherapeutic remodeling of the tumor blood vasculature
Q37259213Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2
Q35664431Dietary restriction promotes vessel maturation in a mouse astrocytoma.
Q41313977Drugs for solid cancer: the productivity crisis prompts a rethink
Q39414887Epithelial-to-Pericyte Transition in Cancer.
Q22252312Hallmarks of Cancer: The Next Generation
Q37509823Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy
Q30579125Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
Q39266457Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis.
Q38094296Imatinib and prostate cancer: lessons learned from targeting the platelet-derived growth factor receptor.
Q36289382Immunohistochemical expression of platelet-derived growth factor receptors in ovarian cancer patients with long-term follow-up.
Q49592831Immunotherapeutic Targeting of Tumor-Associated Blood Vessels
Q38501776Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation
Q35923153Interleukin-6 Stimulates Defective Angiogenesis
Q33592374Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
Q83260552Large hemangiopericytoma associated with arteriovenous malformations and dural arteriovenous fistulae
Q64274739Limitations of Anti-Angiogenic Treatment of Tumors
Q34135852Live-cell imaging of invasion and intravasation in an artificial microvessel platform
Q46120257Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma
Q35025845MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis
Q34972161Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates
Q35893461Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture
Q42571419Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche
Q35034404Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs
Q29547660Microenvironmental regulation of metastasis
Q29547314Molecular mechanisms and clinical applications of angiogenesis
Q36500108Molecular targeting of liposomal nanoparticles to tumor microenvironment
Q38175506New biological treatments for gynecological tumors: focus on angiogenesis
Q38681238Non-coding RNAs in cancer brain metastasis
Q27320507P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments
Q44798933PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs.
Q35024076PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Q27008071Pericyte dynamics during angiogenesis: new insights from new identities
Q35071289Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation
Q92421246Pericytes in Breast Cancer
Q38528174Pericytes in sarcomas of bone
Q37883025Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
Q35221530R-Ras protein inhibits autophosphorylation of vascular endothelial growth factor receptor 2 in endothelial cells and suppresses receptor activation in tumor vasculature
Q98466507Recent Advances on Drug-Loaded Mesenchymal Stem Cells With Anti-neoplastic Agents for Targeted Treatment of Cancer
Q38126398Recruitment and retention: factors that affect pericyte migration.
Q37428915Regulation of vascular integrity.
Q45072551Relevance of epithelial-to-pericyte transition in cancer
Q27016629Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies
Q36284948Role of bone marrow-derived cells in angiogenesis: focus on macrophages and pericytes
Q29615222Role of platelet-derived growth factors in physiology and medicine
Q35550776SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity
Q54271815Scleroderma Mesenchymal Stem Cells display a different phenotype from healthy controls; implications for regenerative medicine.
Q36174151Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels
Q30544130Spontaneous migration of cancer cells under conditions of mechanical confinement
Q37774852Targeting the ANGPT-TIE2 pathway in malignancy
Q36003362The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action
Q40076736Therapeutic potential of novel modulators of neovascularization
Q89638598Towards extracellular matrix normalization for improved treatment of solid tumors
Q39325325Transforming growth factor-beta1 induces microvascular abnormalities through a down-modulation of neural cell adhesion molecule in human hepatocellular carcinoma
Q26747678Tumor refractoriness to anti-VEGF therapy
Q41960757Tumor-derived mural-like cells coordinate with endothelial cells: role of YKL-40 in mural cell-mediated angiogenesis
Q55690308Unraveling the Role of Angiogenesis in Cancer Ecosystems.
Q26781833Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization
Q38126351Vascular remodeling in cancer.
Q36384149Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Search more.