Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development

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Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.0000052
P3181OpenCitations bibliographic resource ID4629355
P932PMC publication ID261889
P698PubMed publication ID14624252
P5875ResearchGate publication ID9003509

P50authorPhilippe SorianoQ55300601
Michelle D TallquistQ57176344
P2093author name stringWendy J French
P2860cites workMechanism of action and in vivo role of platelet-derived growth factorQ22010594
Binding of GAP to activated PDGF receptorsQ24302443
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinasesQ24309883
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase SypQ24310396
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptorQ24310840
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptorQ24311075
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptorsQ24322730
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activationQ24609334
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesisQ24681191
Direct interaction between Shc and the platelet-derived growth factor beta-receptorQ28254337
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signalQ28297924
Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptorQ28359936
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in miceQ28504776
Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung developmentQ28508377
Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouseQ28512852
Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolaeQ28570390
The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functionsQ28585894
Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruliQ28588857
Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesisQ28595010
Signal transduction via platelet-derived growth factor receptorsQ28609164
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitroQ28625928
Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteinsQ28645718
Pericyte loss and microaneurysm formation in PDGF-B-deficient miceQ29615196
Active and inactive protein kinases: structural basis for regulationQ29616320
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseQ29618387
An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.Q52125462
Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.Q52137761
Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors.Q52163714
Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function.Q52169994
Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages.Q52189117
Specific expression in mouse mesoderm- and neural crest-derived tissues of a human PDGFRA promoter/lacZ transgene.Q52189742
Direct and long-range action of a DPP morphogen gradient.Q52201537
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.Q52529779
Drosophila hedgehog acts as a morphogen in cellular patterning.Q52544707
Regulation and role of PDGF receptor alpha-subunit expression during embryogenesisQ67854812
Src family tyrosine kinases and the response to platelet-derived growth factorQ70478999
Widespread recombinase expression using FLPeR (flipper) miceQ73266365
A novel transgenic marker for migrating limb muscle precursors and for vascular smooth muscle cellsQ73367364
PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5Q73451233
Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidneyQ77291514
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytesQ29619826
Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complexQ30450356
Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertilityQ30835829
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalitiesQ33491173
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Q33491174
Developmental biology of the vascular smooth muscle cell: building a multilayered vessel wallQ33537227
Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGFQ33887469
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinaseQ33922224
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathyQ34090428
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.Q34114977
Developmental roles of platelet-derived growth factorsQ34269318
Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responsesQ34668023
Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling MechanismsQ35002367
Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryosQ35206785
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signalingQ35649971
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptorsQ36257661
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiationQ36552522
Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiationQ36564624
Identification of a putative Syp substrate, the PDGF beta receptorQ38291369
DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.Q40021748
Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathwaysQ40445775
Analysis of mural cell recruitment to tumor vesselsQ40759893
Signal transduction by the PDGF receptorsQ40760083
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genesQ40946341
Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP bindingQ40956511
Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesisQ41077471
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane rufflingQ41471394
Regulation of chemotaxis by the platelet-derived growth factor receptor-betaQ41488423
Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.Q41489527
Association between the PDGF receptor and members of the src family of tyrosine kinasesQ41725198
PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complexQ41737568
Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye.Q42636311
The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration.Q42832939
Coupling Met to specific pathways results in distinct developmental outcomesQ43656791
Combinatorial signaling in the specification of unique cell fatesQ46692883
Direct and long-range action of a wingless morphogen gradientQ47071257
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectPlatelet derived growth factor receptor, beta polypeptideQ21983261
P304page(s)E52
P577publication date2003-11-17
P1433published inPLOS BiologyQ1771695
P1476titleAdditive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development
P478volume1

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