Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding

scientific article published on December 1997

Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.8.12.2647
P932PMC publication ID25734
P698PubMed publication ID9398682
P5875ResearchGate publication ID13830836

P50authorCristina PujadesQ42697928
P2093author name stringT A Springer
C Chen
M E Hemler
L C Burkly
R Alon
A Masumoto
R R Lobb
R L Yauch
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Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac developmentQ28507437
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Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit associationQ34207017
Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding siteQ34236515
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.Q34418845
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A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformationQ38339624
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The extracellular matrix as a cell survival factorQ40241699
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Activation Dependent and Independent VLA-4 Binding Sites on Vascular Cell Adhesion Molecule-1Q41466091
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VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.Q41743693
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1.Q41748075
Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)Q41975538
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The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunitQ44542390
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Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptorQ46057359
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Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation.Q46189108
alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flowQ46523925
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Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow.Q52344563
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Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell linesQ58065088
Integrin α chain cytoplasmic tails regulate “antibody-redirected” cell adhesion, independently of ligand bindingQ61961312
Ca(2+)-binding properties of the platelet glycoprotein IIb ligand-interacting domainQ67728165
Determination of residue specificity in the EF-hand of troponin C for Ca2+ coordination, by genetic engineeringQ68225947
Characterization of the cell surface heterodimer VLA-4 and related peptidesQ68827234
Monoclonal antibodies reacting with immunogenic mycoplasma proteins present in human hematopoietic cell linesQ70516662
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Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domainQ71628140
Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) ReceptorQ71797906
Beta 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (alpha L beta 2, CD11a/CD18) and MAC-1 (alpha M beta 2, CD11b/CD18)Q72391924
I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1Q72676487
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcell adhesionQ187640
ligand bindingQ61659151
P304page(s)2647-2657
P577publication date1997-12-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleDefining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding
P478volume8

Reverse relations

cites work (P2860)
Q43925792Analysis of the roles of RGD-binding integrins, alpha(4)/alpha(9) integrins, alpha(6) integrins, and CD9 in the interaction of the fertilin beta (ADAM2) disintegrin domain with the mouse egg membrane
Q41710125Are changes in integrin affinity and conformation overemphasized?
Q40618158Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster
Q24291661Crystal structure of the extracellular segment of integrin alpha Vbeta3
Q41050898Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins
Q42544447Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.
Q38479194Effects of I domain deletion on the function of the beta2 integrin lymphocyte function-associated antigen-1.
Q28207538Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization
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Q24555041Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis
Q34680405Genetic suppression of a phosphomimic myosin II identifies system-level factors that promote myosin II cleavage furrow accumulation
Q58058049Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1
Q77580814Identification of a domain on the integrin alpha5 subunit implicated in cell spreading and signaling
Q34862258Integrin structure: new twists and turns in dynamic cell adhesion
Q46465757Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activation
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Q88093641Observation of Giant Conductance Fluctuations in a Protein
Q34496409Platelet integrin alphaIIbbeta3-ligand interactions: what can we learn from the structure?
Q34100107The regulation of integrin function by Ca(2+).

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