The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

scientific article

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.128.6.1243
P932PMC publication ID2120426
P698PubMed publication ID7534768
P5875ResearchGate publication ID277460320

P50authorRonen AlonQ56931491
P2093author name stringT A Springer
M E Hemler
P D Kassner
M W Carr
E B Finger
P2860cites workStructure/function studies on vascular cell adhesion molecule-1Q24293204
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P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cellsQ34019840
Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1.Q34138925
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GMP-140 (P-selectin/CD62) binds to chronically stimulated but not resting CD4+ T lymphocytes and regulates their production of proinflammatory cytokinesQ67539003
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L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivoQ71651106
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Selectin-mediated rolling of neutrophils on immobilized plateletsQ72091458
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Selectins: interpreters of cell-specific carbohydrate information during inflammationQ35532358
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Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectinQ36221398
Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibodyQ36232350
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Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.Q36234852
Lymphocyte interactions with endothelial cellsQ36286240
Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectinQ36361481
Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrinQ36362015
Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1Q36378710
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.Q36383058
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrinsQ36534910
Culture of vascular endotheliumQ37051954
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Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivoQ37583902
VLA proteins in the integrin family: structures, functions, and their role on leukocytesQ37925528
Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion.Q38305572
Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells.Q39200588
Leukocyte-endothelial adhesion moleculesQ40392834
Origins of DNA replication in metazoan chromosomesQ40867471
In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromesQ41021858
L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectinQ41532547
Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.Q41541656
L-selectin mediates neutrophil rolling in inflamed venules through sialyl LewisX-dependent and -independent recognition pathways.Q41546428
Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1Q41579068
Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domainsQ41634320
ELAM-1 is an adhesion molecule for skin-homing T cellsQ41694765
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1.Q41748075
Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venulesQ42118588
Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).Q44645544
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.Q46007698
Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptorQ46046659
L-selectin-mediated lymphocyte rolling on MAdCAM-1.Q46407093
Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response.Q52065012
P-selectin (CD62) binds to subpopulations of human memory T lymphocytes and natural killer cellsQ52073381
Activation-independent binding of human memory T cells to adhesion molecule ELAM-1.Q52100397
Differential expression of homing-associated adhesion molecules by T cell subsets in manQ52104629
Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation.Q52107908
Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo.Q53029393
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.Q54296088
Leukocyte-endothelium adhesion: microhemodynamics in mesentery of the cat.Q54397805
Quantitation and kinetics of blood monocyte migration to acute inflammatory reactions, and IL-1 alpha, tumor necrosis factor-alpha, and IFN-gamma.Q54652889
Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesionQ58058347
A high affinity conformational state on VLA integrin heterodimers induced by an anti-beta 1 chain monoclonal antibodyQ58064707
VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterizationQ58065014
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1243-1253
P577publication date1995-03-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe integrin VLA-4 supports tethering and rolling in flow on VCAM-1
P478volume128

Reverse relations

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Q28293910Targeting leukocyte integrins in human diseases
Q30488087Targeting mesenchymal stem cells to activated endothelial cells
Q73685212Temporal correlation of tumor necrosis factor-alpha release, upregulation of pulmonary ICAM-1 and VCAM-1, neutrophil sequestration, and lung injury in diet-induced pancreatitis
Q36274122Tenascin supports lymphocyte rolling
Q44625272Th1 Cell-Mediated Resistance to Cutaneous Infection with Leishmania major Is Independent of P- and E-Selectins
Q71066482The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes
Q37381694The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow
Q34075924The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion
Q44610040The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.
Q47591662The ICAM-1 expression level determines the susceptibility of human endothelial cells to simulated microgravity.
Q41152278The alpha 4 beta 1 fibronectin ligands CS-1, Hep II, and RGD induce different intracellular events in B lymphoid cells. Comparison with the effects of the endothelial ligand VCAM-1.
Q42943483The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo
Q28145821The alpha(4) integrin subunit Tyr(187) has a key role in alpha(4)beta(7)-dependent cell adhesion
Q33774215The alpha4-integrin: an alternative pathway for neutrophil recruitment?
Q36377024The association between alpha4-integrin, P-selectin, and E-selectin in an allergic model of inflammation
Q90013704The bioenergetics of integrin-based adhesion, from single molecule dynamics to stability of macromolecular complexes
Q40857641The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow
Q52039719The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig.
Q37387115The combined role of P- and E-selectins in atherosclerosis
Q27335910The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged
Q38351114The expression, regulation and adhesion function of a novel CD molecule, CD226, on human endothelial cells
Q34862240The immunological synapse: integrins take the stage.
Q37343216The involvement of endothelial mediators in leprosy
Q52015962The role of antigen in the localization of naive, acutely activated, and memory CD8(+) T cells to the lung during influenza pneumonia.
Q46343438The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodeling
Q28910405The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the alpha4beta1 integrin
Q35270198The state diagram for cell adhesion under flow: leukocyte rolling and firm adhesion
Q27760354The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition
Q73676784Therapeutic efficacy of adoptive immunotherapy is predicated on in vivo antigen-specific proliferation of donor T cells
Q36211855Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?
Q30442171Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L,P,E)
Q34438768Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3·Bcl10·MALT1 signalosome
Q33811749Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells
Q30667752Time-lapse contact microscopy of cell cultures based on non-coherent illumination
Q35898564Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
Q35925482Transport features, reaction kinetics and receptor biomechanics controlling selectin and integrin mediated cell adhesion.
Q37111904Treating multiple sclerosis with monoclonal antibodies
Q33700997Treatment of refractory epilepsy with natalizumab in a patient with multiple sclerosis. Case report
Q35548795Tumour necrosis factor alpha stimulated rheumatoid synovial microvascular endothelial cells exhibit increased shear rate dependent leucocyte adhesion in vitro
Q37183219Two-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow
Q38309472Unique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion
Q34050022Urinary biomarkers in lupus nephritis
Q33370533VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasis
Q41039630VCAM-1 is internalized by a clathrin-related pathway in human endothelial cells but its alpha 4 beta 1 integrin counter-receptor remains associated with the plasma membrane in human T lymphocytes
Q37263935VCAM-1 signals activate endothelial cell protein kinase Calpha via oxidation
Q61021993VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice
Q40654707VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration
Q98466159VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer
Q90631688VLA-4 Expression and Activation in B Cell Malignancies: Functional and Clinical Aspects
Q90338881VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1
Q30442829Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes
Q35151318Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants
Q42837656α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin

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