Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction

scientific article published on April 2004

Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1074-7613(04)00082-2
P698PubMed publication ID15084269
P5875ResearchGate publication ID252232645

P50authorUlrich von AndrianQ7879876
P2093author name stringTimothy A Springer
Motomu Shimaoka
Azucena Salas
Charlotte Harwood
Avi N Kogan
P2860cites workCrystal structure of the extracellular segment of integrin alpha Vbeta3Q24291661
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Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivoQ30448792
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Integrin structureQ33915456
Role of CD11/CD18 in shear rate-dependent leukocyte-endothelial cell interactions in cat mesenteric venulesQ34189766
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An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.Q34461123
Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domainsQ34461566
Conformational regulation of integrin structure and functionQ34623640
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligandQ34805673
Predicted and experimental structures of integrins and beta-propellersQ35035269
L-selectin-mediated leukocyte adhesion in vivo: microvillous distribution determines tethering efficiency, but not rolling velocityQ35834636
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivoQ35925494
Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunitQ36081222
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.Q36235481
The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils.Q36369393
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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand bindingQ36967455
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factorQ37373855
Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivoQ37583902
Discontinuous density gradient separation of human minonuclear leucocytes using percoll® as gradient mediumQ39288243
Structure of integrin alpha5beta1 in complex with fibronectinQ39958701
Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.Q40045504
Bistable regulation of integrin adhesiveness by a bipolar metal ion clusterQ40618158
Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibitionQ40758356
Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activationQ40811225
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flowQ41092560
Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flowQ41357024
Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small moleculeQ42162451
High affinity ligand binding by integrins does not involve head separationQ42437423
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin siteQ43625666
Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interactionQ43638046
Identification of the principal binding site for RGD-containing ligands in the alpha(V)beta(3) integrin: a photoaffinity cross-linking studyQ44039504
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signalingQ44136286
Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.Q44170571
Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.Q44519392
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the otherQ44589706
alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flowQ46523925
In situ analysis of lymphocyte migration to lymph nodes.Q52036770
Chemokines and the arrest of lymphocytes rolling under flow conditions.Q52040689
Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial.Q53361774
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.Q54296088
Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain MovementQ58057915
The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environmentQ73910781
Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvesselsQ73998199
Does the integrin alphaA domain act as a ligand for its betaA domain?Q74114309
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)393-406
P577publication date2004-04-01
P1433published inImmunityQ6005457
P1476titleRolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction
P478volume20

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