scholarly article | Q13442814 |
P50 | author | Ulrich von Andrian | Q7879876 |
P2093 | author name string | Timothy A Springer | |
Motomu Shimaoka | |||
Azucena Salas | |||
Charlotte Harwood | |||
Avi N Kogan | |||
P2860 | cites work | Crystal structure of the extracellular segment of integrin alpha Vbeta3 | Q24291661 |
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand | Q24292425 | ||
Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3 | Q24628750 | ||
Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain | Q27619685 | ||
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation | Q27638359 | ||
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation | Q27640304 | ||
Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction | Q28204891 | ||
T-Cell Function and Migration — Two Sides of the Same Coin | Q29041098 | ||
Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm | Q29547181 | ||
Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice | Q30306581 | ||
Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. | Q30306719 | ||
Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo | Q30448792 | ||
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties | Q30649179 | ||
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2). | Q31628426 | ||
Integrin structure | Q33915456 | ||
Role of CD11/CD18 in shear rate-dependent leukocyte-endothelial cell interactions in cat mesenteric venules | Q34189766 | ||
Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography | Q34391821 | ||
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond. | Q34461123 | ||
Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains | Q34461566 | ||
Conformational regulation of integrin structure and function | Q34623640 | ||
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand | Q34805673 | ||
Predicted and experimental structures of integrins and beta-propellers | Q35035269 | ||
L-selectin-mediated leukocyte adhesion in vivo: microvillous distribution determines tethering efficiency, but not rolling velocity | Q35834636 | ||
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo | Q35925494 | ||
Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit | Q36081222 | ||
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. | Q36235481 | ||
The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils. | Q36369393 | ||
Molecular mechanisms of lymphocyte homing to peripheral lymph nodes | Q36400133 | ||
Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice. | Q36400175 | ||
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions | Q36601714 | ||
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. | Q36852850 | ||
NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding | Q36967455 | ||
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor | Q37373855 | ||
Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo | Q37583902 | ||
Discontinuous density gradient separation of human minonuclear leucocytes using percoll® as gradient medium | Q39288243 | ||
Structure of integrin alpha5beta1 in complex with fibronectin | Q39958701 | ||
Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules. | Q40045504 | ||
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster | Q40618158 | ||
Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition | Q40758356 | ||
Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation | Q40811225 | ||
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow | Q41092560 | ||
Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flow | Q41357024 | ||
Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule | Q42162451 | ||
High affinity ligand binding by integrins does not involve head separation | Q42437423 | ||
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site | Q43625666 | ||
Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction | Q43638046 | ||
Identification of the principal binding site for RGD-containing ligands in the alpha(V)beta(3) integrin: a photoaffinity cross-linking study | Q44039504 | ||
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling | Q44136286 | ||
Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1. | Q44170571 | ||
Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. | Q44519392 | ||
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other | Q44589706 | ||
alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow | Q46523925 | ||
In situ analysis of lymphocyte migration to lymph nodes. | Q52036770 | ||
Chemokines and the arrest of lymphocytes rolling under flow conditions. | Q52040689 | ||
Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial. | Q53361774 | ||
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. | Q54296088 | ||
Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement | Q58057915 | ||
The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment | Q73910781 | ||
Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels | Q73998199 | ||
Does the integrin alphaA domain act as a ligand for its betaA domain? | Q74114309 | ||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 393-406 | |
P577 | publication date | 2004-04-01 | |
P1433 | published in | Immunity | Q6005457 |
P1476 | title | Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction | |
P478 | volume | 20 |
Q24676189 | A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets |
Q38095502 | A daunting task: manipulating leukocyte function with RNAi |
Q43200676 | A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood. |
Q47699535 | A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding |
Q30478693 | A small molecule agonist of an integrin, alphaLbeta2. |
Q35080405 | AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes. |
Q40347084 | Activated β2 Integrins Restrict Neutrophil Recruitment during Murine Acute Pseudomonal Pneumonia. |
Q42403746 | Adhesive dynamics simulation of neutrophil arrest with deterministic activation |
Q36791203 | Adhesive dynamics simulation of neutrophil arrest with stochastic activation |
Q57146633 | An Experimentally Determined State Diagram for Human CD4 T Lymphocyte CXCR4-Stimulated Adhesion Under Shear Flow |
Q27681159 | An internal ligand-bound, metastable state of a leukocyte integrin, α X β 2 |
Q42051797 | Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion. |
Q35894364 | Blocking neutrophil integrin activation prevents ischemia-reperfusion injury |
Q37270602 | CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions |
Q43277216 | Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding |
Q43043542 | Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. |
Q30514206 | Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation |
Q30479646 | Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium |
Q27317712 | Elastohydrodynamics and Kinetics of Protein Patterning in the Immunological Synapse |
Q28821976 | Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion |
Q42542148 | Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. |
Q34786041 | FRET detection of lymphocyte function-associated antigen-1 conformational extension. |
Q30497295 | Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds |
Q30440796 | Galphai2 is required for chemokine-induced neutrophil arrest |
Q33340853 | Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion |
Q29547271 | Getting to the site of inflammation: the leukocyte adhesion cascade updated |
Q36295454 | Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation |
Q92809875 | Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells |
Q40209543 | Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration |
Q34351893 | I-domain of lymphocyte function-associated antigen-1 mediates rolling of polystyrene particles on ICAM-1 under flow |
Q52656807 | Imaging of atherosclerosis, targeting LFA-1 on inflammatory cells with 111In-DANBIRT. |
Q36769474 | Integrin regulation of lymphocyte trafficking: lessons from structural and signaling studies |
Q26773026 | Integrin-based therapeutics: biological basis, clinical use and new drugs |
Q37795552 | Integrins as therapeutic targets: lessons and opportunities |
Q35545470 | Interplay between shear stress and adhesion on neutrophil locomotion |
Q34780082 | Isolation of αL I domain mutants mediating firm cell adhesion using a novel flow-based sorting method |
Q39805693 | LFA-1 antagonists as agents limiting human immunodeficiency virus type 1 infection and transmission and potentiating the effect of the fusion inhibitor T-20. |
Q37907192 | LFA-1 fine-tuning by cathepsin X. |
Q38009359 | Leucocyte recruitment in inflammation and novel endogenous negative regulators thereof |
Q36908674 | Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation |
Q46350335 | Leukocyte function-associated antigen 1-mediated adhesion stability is dynamically regulated through affinity and valency during bond formation with intercellular adhesion molecule-1. |
Q53839655 | Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1. |
Q33795695 | Long-lived, high-strength states of ICAM-1 bonds to beta2 integrin, I: lifetimes of bonds to recombinant alphaLbeta2 under force. |
Q81657102 | Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines |
Q30492673 | Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. |
Q27016079 | Mechanical regulation of T-cell functions |
Q30441417 | Mechanisms and consequences of neutrophil interaction with the endothelium |
Q37167419 | Mechanisms of neutrophil transendothelial migration |
Q35928329 | Membrane dynamics shape TCR-generated signaling. |
Q37465449 | Molecular basis of leukocyte-endothelium interactions during the inflammatory response. |
Q24816782 | Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA. |
Q33598453 | Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. |
Q39441019 | Mutagenesis studies of the β I domain metal ion binding sites on integrin αVβ3 ligand binding affinity |
Q36806108 | Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3. |
Q38018949 | Neutrophil arrest by LFA-1 activation |
Q30009577 | Neutrophil cell surface receptors and their intracellular signal transduction pathways. |
Q96609779 | Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo |
Q55617999 | Novel aspects in the regulation of the leukocyte adhesion cascade. |
Q42584075 | Novel automated tracking analysis of particles subjected to shear flow: kindlin-3 role in B cells |
Q39248514 | Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. |
Q30527786 | Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells. |
Q27303034 | PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier |
Q30439982 | PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling |
Q52938039 | Poly(ethylene glycol)-containing hydrogels modulate α-defensin release from polymorphonuclear leukocytes and monocyte recruitment. |
Q39878470 | Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation |
Q35063491 | Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. |
Q37084884 | Regulation of T-cell migration and effector functions: insights from in vivo imaging studies |
Q35626360 | Regulation of integrin affinity on cell surfaces |
Q35016499 | Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2. |
Q37540219 | Rolling cell adhesion |
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Q37271987 | Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier |
Q30440643 | Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. |
Q27312068 | Structural basis and kinetics of force-induced conformational changes of an αA domain-containing integrin |
Q29617618 | Structural basis of integrin regulation and signaling |
Q36844463 | Structural modifications of ICAM-1 cyclic peptides to improve the activity to inhibit heterotypic adhesion of T cells |
Q28293910 | Targeting leukocyte integrins in human diseases |
Q24812900 | The CD11a partner in Sus scrofa lymphocyte function-associated antigen-1 (LFA-1): mRNA cloning, structure analysis and comparison with mammalian homologues |
Q30490766 | The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells |
Q40115406 | The cytosolic protein talin induces an intermediate affinity integrin alphaLbeta2. |
Q37593131 | The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation |
Q36322824 | The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. |
Q35998499 | The regulation of integrin function by divalent cations |
Q35215649 | The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. |
Q37997074 | The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment |
Q35925845 | The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion |
Q33302692 | The wild boar (Sus scrofa) lymphocyte function-associated antigen-1 (CD11a/CD18) receptor: cDNA sequencing, structure analysis and comparison with homologues |
Q46352136 | Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress |
Q35080240 | Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state |
Q35688290 | Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase |
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Q51798862 | Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding. |
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