Blocking neutrophil integrin activation prevents ischemia-reperfusion injury

scientific article published on 13 July 2015

Blocking neutrophil integrin activation prevents ischemia-reperfusion injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20142358
P932PMC publication ID4516797
P698PubMed publication ID26169939
P5875ResearchGate publication ID280058415

P50authorNan ZhangQ57338721
P2093author name stringMark H Ginsberg
Brian G Petrich
Rodger P McEver
Zhenghui Liu
Tadayuki Yago
Bojing Shao
P2860cites workIntraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascadeQ42178238
A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammationQ42425839
Rapid recruitment of inflammatory monocytes is independent of neutrophil migrationQ44353696
Critical protection from renal ischemia reperfusion injury by CD55 and CD59.Q44788674
Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrowQ44997562
Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domainQ46171254
Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins.Q52213481
Multiphoton intravital microscopy of the transplanted mouse kidneyQ84747256
Adhesion molecules involved in neutrophil recruitment during sepsis-induced acute kidney injuryQ87373068
Distinct chemokine signaling regulates integrin ligand specificity to dictate tissue-specific lymphocyte homingQ88130315
Structural basis of integrin activation by talinQ24292977
Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flowQ27027232
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic faceQ27639651
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Q27657634
A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesionQ27681229
Ratio of local to systemic chemokine concentrations regulates neutrophil recruitmentQ28346168
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cellsQ28507135
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsQ28585779
Vav GEFs are required for beta2 integrin-dependent functions of neutrophilsQ28590406
Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in miceQ28593286
Kindlin-3 is essential for integrin activation and platelet aggregationQ28595084
Getting to the site of inflammation: the leukocyte adhesion cascade updatedQ29547271
Neutrophils and immunity: challenges and opportunitiesQ29617616
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin ActivationQ29617809
Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure.Q30304594
Protection from ischemia-reperfusion induced severe acute renal failure by blocking E-selectinQ30305909
Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesionsQ30371366
Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rollingQ30426195
Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophilsQ30427418
CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivoQ30434720
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injuryQ30437432
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rollingQ30439982
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.Q30440643
Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivoQ30448792
P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flowQ30453100
Sequential contribution of L- and P-selectin to leukocyte rolling in vivoQ30463937
Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivoQ30469729
Talin depletion reveals independence of initial cell spreading from integrin activation and tractionQ30490335
Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathwaysQ30494206
Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch BondsQ30497295
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophilsQ30504374
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulationQ30514206
Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.Q30514480
IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activationQ30515381
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells.Q30527786
Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cellsQ30552379
New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clusteringQ33590915
Disruption of the talin gene arrests mouse development at the gastrulation stageQ33925712
Core 1-derived O-glycans are essential E-selectin ligands on neutrophilsQ33927218
E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rollingQ34033865
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.Q34111723
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile InflammationQ34143696
Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.Q34181908
A role of kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axisQ34599695
Talin-dependent integrin activation is required for fibrin clot retraction by plateletsQ34667580
Biochemical and structural properties of the integrin-associated cytoskeletal protein talinQ34979246
Recent advances in the pathophysiology of ischemic acute renal failureQ35182393
Regulation of integrin affinity on cell surfacesQ35626360
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.Q35651662
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injuryQ35760832
Talin activates integrins by altering the topology of the β transmembrane domainQ36002154
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signalingQ36007725
Talin is required for integrin-mediated platelet function in hemostasis and thrombosisQ36294415
Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α releaseQ36836965
Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flowQ36843799
LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient miceQ37365253
The ins and outs of leukocyte integrin signalingQ37419383
The tail of integrins, talin, and kindlinsQ37483142
Rolling cell adhesionQ37540219
The mechanism of kindlin-mediated activation of integrin αIIbβ3.Q37552184
A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleedingQ37723482
Pathophysiology of ischemic acute kidney injuryQ37848648
Regulation of integrin activationQ37887794
The neutrophil in vascular inflammationQ37953775
Neutrophil arrest by LFA-1 activationQ38018949
Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts.Q38024452
Talin and kindlin: the one-two punch in integrin activationQ38183284
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interactionQ40566983
Involvement of Src kinases and PLCgamma2 in clot retractionQ42026902
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectreperfusion injuryQ1413991
P304page(s)1267-1281
P577publication date2015-07-13
P1433published inJournal of Experimental MedicineQ3186912
P1476titleBlocking neutrophil integrin activation prevents ischemia-reperfusion injury
P478volume212

Reverse relations

cites work (P2860)
Q96299455A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis
Q57146633An Experimentally Determined State Diagram for Human CD4 T Lymphocyte CXCR4-Stimulated Adhesion Under Shear Flow
Q52670226Cell Death Mechanisms in Stroke and Novel Molecular and Cellular Treatment Options.
Q90696002Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice
Q38872727Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes
Q41810389Dampening neutrophil integrins
Q60907233Endothelial signaling by neutrophil-released oncostatin M enhances P-selectin–dependent inflammation and thrombosis
Q98280885Epsin-mediated degradation of IP3R1 fuels atherosclerosis
Q91709762Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity
Q64376713Ferulic Acid Protected from Kidney Ischemia Reperfusion Injury in Mice: Possible Mechanism Through Increasing Adenosine Generation via HIF-1α
Q93049938Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling
Q38608338How leukocytes cross the vascular endothelium
Q64260024Hydroxyethyl Starch 130/0.4 Binds to Neutrophils Impairing Their Chemotaxis through a Mac-1 Dependent Interaction
Q92242442Identification of primary genes in glomeruli compartment of immunoglobulin A nephropathy by bioinformatic analysis
Q52716109Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance.
Q52617937Ischaemia reperfusion injury: mechanisms of progression to chronic graft dysfunction.
Q30851884L-selectin mechanochemistry restricts neutrophil priming in vivo.
Q36908674Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation
Q92914442Mechanisms of haemolysis-induced kidney injury
Q38866827Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review
Q52313021Neutrophil phenotypes in health and disease.
Q47232399Proteasome and Organs Ischemia-Reperfusion Injury
Q48413544Remote Limb Ischemic Preconditioning Protects Rats Against Cerebral Ischemia via HIF-1α/AMPK/HSP70 Pathway
Q85657235Renal injury: Prevention of talin-1-mediated activation of neutrophils protects against renal ischaemia-reperfusion injury
Q36466204Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice.
Q88204080Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils
Q99200602Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination
Q30829904Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity
Q39431307Talin - the master of integrin adhesions.
Q38840456The Rap1-RIAM-talin axis of integrin activation and blood cell function

Search more.