| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2004PNAS..101.2333Y |
| P356 | DOI | 10.1073/PNAS.0307291101 |
| P932 | PMC publication ID | 356951 |
| P698 | PubMed publication ID | 14983010 |
| P5875 | ResearchGate publication ID | 242908091 |
| P2093 | author name string | Timothy A Springer | |
| Wei Yang | |||
| Motomu Shimaoka | |||
| JianFeng Chen | |||
| P2860 | cites work | Crystal structure of the extracellular segment of integrin alpha Vbeta3 | Q24291661 |
| Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand | Q24292425 | ||
| Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain | Q27619685 | ||
| Structural basis of collagen recognition by integrin alpha2beta1 | Q27622310 | ||
| Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation | Q27638359 | ||
| A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face | Q27639651 | ||
| Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation | Q27640304 | ||
| Two conformations of the integrin A-domain (I-domain): a pathway for activation? | Q27733272 | ||
| Integrins: bidirectional, allosteric signaling machines | Q27860700 | ||
| Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction | Q28204891 | ||
| Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation | Q29617809 | ||
| Integrin activation and structural rearrangement | Q30848202 | ||
| Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits | Q33944363 | ||
| An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond. | Q34461123 | ||
| Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains | Q34461566 | ||
| Conformational regulation of integrin structure and function | Q34623640 | ||
| Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand | Q34805673 | ||
| Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo | Q35925494 | ||
| Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit | Q36081222 | ||
| NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding | Q36967455 | ||
| Structure of integrin alpha5beta1 in complex with fibronectin | Q39958701 | ||
| Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster | Q40618158 | ||
| Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition | Q40758356 | ||
| Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation | Q40811225 | ||
| Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits | Q40822276 | ||
| Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain | Q40884299 | ||
| Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events | Q42804998 | ||
| Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site | Q43625666 | ||
| The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1). | Q43891705 | ||
| Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain | Q43917527 | ||
| Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling | Q44136286 | ||
| Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other | Q44589706 | ||
| Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins | Q44590985 | ||
| Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. | Q44610044 | ||
| Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies | Q45983410 | ||
| Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement | Q58057915 | ||
| The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy | Q58058153 | ||
| The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1 | Q73453113 | ||
| Does the integrin alphaA domain act as a ligand for its betaA domain? | Q74114309 | ||
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2333-2338 | |
| P577 | publication date | 2004-02-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions | |
| P478 | volume | 101 |
| Q40024433 | A mechanism for antibody-mediated outside-in activation of LFA-1. |
| Q30478693 | A small molecule agonist of an integrin, alphaLbeta2. |
| Q35566368 | Anchorage-dependent binding of integrin I-domain to adhesion ligands |
| Q34411435 | Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha4beta7 |
| Q27678790 | Complete integrin headpiece opening in eight steps |
| Q30479646 | Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium |
| Q42542148 | Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. |
| Q30480541 | How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation |
| Q37031940 | Identification of integrin beta subunit mutations that alter heterodimer function in situ |
| Q35578469 | Importance of force linkage in mechanochemistry of adhesion receptors. |
| Q45013818 | Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo |
| Q36769474 | Integrin regulation of lymphocyte trafficking: lessons from structural and signaling studies |
| Q36564206 | Integrin structures and conformational signaling |
| Q88778196 | Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation |
| Q36908674 | Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation |
| Q37045308 | Leukocyte function antigen-1, kindlin-3, and calcium flux orchestrate neutrophil recruitment during inflammation |
| Q39441019 | Mutagenesis studies of the β I domain metal ion binding sites on integrin αVβ3 ligand binding affinity |
| Q36806108 | Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3. |
| Q27329905 | Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis. |
| Q43188550 | Rationally designed integrin beta3 mutants stabilized in the high affinity conformation |
| Q35016499 | Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2. |
| Q40566983 | Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction |
| Q35213036 | Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics |
| Q29617618 | Structural basis of integrin regulation and signaling |
| Q36744293 | Structure and mechanics of integrin-based cell adhesion. |
| Q42582837 | Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins |
| Q36580090 | Targeting integrin structure and function in disease |
| Q35605015 | The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrins |
| Q36088716 | The connection between metal ion affinity and ligand affinity in integrin I domains |
| Q35215649 | The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. |
| Q35925845 | The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion |
| Q36850278 | The unique disulfide bond-stabilized W1 β4-β1 loop in the α4 β-propeller domain regulates integrin α4β7 affinity and signaling |
| Q35014901 | Variation in one residue associated with the metal ion-dependent adhesion site regulates αIIbβ3 integrin ligand binding affinity |
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