How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation

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How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.200602071
P932PMC publication ID2064575
P698PubMed publication ID17060501
P5875ResearchGate publication ID6734599

P50authorViola VogelQ15303638
Klaus SchultenQ19665429
P2093author name stringMu Gao
Eileen Puklin-Faucher
P2860cites workCrystal structure of the extracellular segment of integrin alpha Vbeta3Q24291661
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrinsQ44590985
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug designQ44604117
Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.Q44610044
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domainQ44881202
Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under forceQ45141951
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity stateQ45182918
The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.Q45938073
Protein domain movements: detection of rigid domains and visualization of hinges in comparisons of atomic coordinates.Q52256509
Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain MovementQ58057915
Two-step binding mechanism of fibrinogen to alpha IIb beta 3 integrin reconstituted into planar lipid bilayersQ70614647
Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on plateletsQ73309367
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligandQ24292425
A specific interface between integrin transmembrane helices and affinity for ligandQ24793060
Comparison of simple potential functions for simulating liquid waterQ26778447
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activationQ27638359
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy regionQ27732239
Two conformations of the integrin A-domain (I-domain): a pathway for activation?Q27733272
Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structureQ27749035
All-atom empirical potential for molecular modeling and dynamics studies of proteinsQ27860468
VMD: visual molecular dynamicsQ27860554
Integrins: bidirectional, allosteric signaling machinesQ27860700
Scalable molecular dynamics with NAMDQ27860718
Integrins in mechanotransductionQ28244898
Local force and geometry sensing regulate cell functionsQ29616036
Integrin activation and structural rearrangementQ30848202
Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalphaQ33229031
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.Q33928601
Steered molecular dynamics and mechanical functions of proteinsQ33942097
Will the real integrin please stand up?Q34641428
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligandQ34805673
New insights into the structural basis of integrin activation.Q35114650
Integrin structure: heady advances in ligand binding, but activation still makes the knees wobbleQ35162578
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeuticsQ35213036
Adhesion-dependent cell mechanosensitivity.Q35564866
Mechanobiology and diseases of mechanotransductionQ35622033
Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectinQ36321549
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletionsQ36601714
The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activationQ37593131
Structure of integrin alpha5beta1 in complex with fibronectinQ39958701
Electron tomography reveals diverse conformations of integrin alphaIIbbeta3 in the active stateQ40423501
Bistable regulation of integrin adhesiveness by a bipolar metal ion clusterQ40618158
Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.Q41272684
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.Q42238933
Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.Q42542148
Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domainQ43917527
Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activationQ44078626
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signalingQ44136286
Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.Q44519392
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)349-360
P577publication date2006-10-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleHow the headpiece hinge angle is opened: New insights into the dynamics of integrin activation
P478volume175

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