scholarly article | Q13442814 |
P50 | author | Viola Vogel | Q15303638 |
Klaus Schulten | Q19665429 | ||
P2093 | author name string | Mu Gao | |
Eileen Puklin-Faucher | |||
P2860 | cites work | Crystal structure of the extracellular segment of integrin alpha Vbeta3 | Q24291661 |
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins | Q44590985 | ||
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design | Q44604117 | ||
Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. | Q44610044 | ||
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain | Q44881202 | ||
Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under force | Q45141951 | ||
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state | Q45182918 | ||
The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. | Q45938073 | ||
Protein domain movements: detection of rigid domains and visualization of hinges in comparisons of atomic coordinates. | Q52256509 | ||
Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement | Q58057915 | ||
Two-step binding mechanism of fibrinogen to alpha IIb beta 3 integrin reconstituted into planar lipid bilayers | Q70614647 | ||
Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets | Q73309367 | ||
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand | Q24292425 | ||
A specific interface between integrin transmembrane helices and affinity for ligand | Q24793060 | ||
Comparison of simple potential functions for simulating liquid water | Q26778447 | ||
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation | Q27638359 | ||
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region | Q27732239 | ||
Two conformations of the integrin A-domain (I-domain): a pathway for activation? | Q27733272 | ||
Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure | Q27749035 | ||
All-atom empirical potential for molecular modeling and dynamics studies of proteins | Q27860468 | ||
VMD: visual molecular dynamics | Q27860554 | ||
Integrins: bidirectional, allosteric signaling machines | Q27860700 | ||
Scalable molecular dynamics with NAMD | Q27860718 | ||
Integrins in mechanotransduction | Q28244898 | ||
Local force and geometry sensing regulate cell functions | Q29616036 | ||
Integrin activation and structural rearrangement | Q30848202 | ||
Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha | Q33229031 | ||
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. | Q33928601 | ||
Steered molecular dynamics and mechanical functions of proteins | Q33942097 | ||
Will the real integrin please stand up? | Q34641428 | ||
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand | Q34805673 | ||
New insights into the structural basis of integrin activation. | Q35114650 | ||
Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble | Q35162578 | ||
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics | Q35213036 | ||
Adhesion-dependent cell mechanosensitivity. | Q35564866 | ||
Mechanobiology and diseases of mechanotransduction | Q35622033 | ||
Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin | Q36321549 | ||
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions | Q36601714 | ||
The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation | Q37593131 | ||
Structure of integrin alpha5beta1 in complex with fibronectin | Q39958701 | ||
Electron tomography reveals diverse conformations of integrin alphaIIbbeta3 in the active state | Q40423501 | ||
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster | Q40618158 | ||
Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+. | Q41272684 | ||
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. | Q42238933 | ||
Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. | Q42542148 | ||
Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain | Q43917527 | ||
Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation | Q44078626 | ||
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling | Q44136286 | ||
Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. | Q44519392 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 349-360 | |
P577 | publication date | 2006-10-01 | |
P1433 | published in | Journal of Cell Biology | Q1524550 |
P1476 | title | How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation | |
P478 | volume | 175 |
Q90161901 | A Systematic Test of Receptor Binding Kinetics for Ligands in Tumor Necrosis Factor Superfamily by Computational Simulations |
Q81318568 | A catch to integrin activation |
Q89539297 | A computational model for understanding the oligomerization mechanisms of TNF receptor superfamily |
Q37369037 | A model for cyclic mechanical reinforcement |
Q34634757 | A single disulfide bond disruption in the β3 integrin subunit promotes thiol/disulfide exchange, a molecular dynamics study |
Q33809484 | Acidic extracellular pH promotes activation of integrin α(v)β(3). |
Q50946720 | Activation mechanisms of αVβ3 integrin by binding to fibronectin: A computational study. |
Q39915665 | Biomimetic poly(amidoamine) hydrogels as synthetic materials for cell culture. |
Q37293577 | Catch-bond mechanism of force-enhanced adhesion: counterintuitive, elusive, but ... widespread? |
Q37300621 | Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling |
Q37393132 | Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways |
Q37171421 | Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells |
Q37600445 | Chapter 1. Focal adhesions: new angles on an old structure. |
Q37849903 | Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers. |
Q27678790 | Complete integrin headpiece opening in eight steps |
Q34016460 | Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1 |
Q50134409 | Controlling Cellular Volume via Mechanical and Physical Properties of Substrate |
Q27657149 | Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment |
Q37267611 | Demonstration of catch bonds between an integrin and its ligand. |
Q34443614 | Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force |
Q64120635 | Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes |
Q42795966 | Electrical control of protein conformation |
Q53185002 | Elucidating the general principles of cell adhesion with a coarse-grained simulation model. |
Q29615211 | Environmental sensing through focal adhesions |
Q91523081 | Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α5β1 integrin towards choleresis |
Q38026498 | Finding the weakest link: exploring integrin-mediated mechanical molecular pathways |
Q30434743 | Focal adhesions are sites of integrin extension |
Q51246524 | Force regulated conformational change of integrin αVβ3. |
Q30497295 | Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds |
Q28072132 | Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments |
Q36257638 | High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular Design |
Q41239491 | In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field |
Q37479425 | Integrin activation dynamics between the RGD-binding site and the headpiece hinge |
Q46824098 | Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli |
Q30423615 | Integrins and extracellular matrix in mechanotransduction |
Q92349966 | Integrins, CAFs and Mechanical Forces in the Progression of Cancer |
Q37810633 | Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation |
Q30512956 | Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion |
Q37360844 | Linking integrin conformation to function |
Q28115946 | Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces |
Q38127775 | Matrix mechanics and regulation of the fibroblast phenotype |
Q35699122 | Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling. |
Q27016079 | Mechanical regulation of T-cell functions |
Q50120833 | Mechanosensation: A Catch Bond That Only Hooks One Way. |
Q57591551 | Molecular Dynamics Reveal that isoDGR-Containing Cyclopeptides Are True αvβ3 Antagonists Unable To Promote Integrin Allostery and Activation |
Q57953602 | Molecular Dynamics Reveal that isoDGR-Containing Cyclopeptides Are True αvβ3 Antagonists Unable To Promote Integrin Allostery and Activation |
Q27334036 | Molecular dynamics simulations of forced unbending of integrin α(v)β₃ |
Q33841582 | Neutrophil adhesion and chemotaxis depend on substrate mechanics |
Q38223234 | Non-channel mechanosensors working at focal adhesion-stress fiber complex. |
Q39862600 | Phenomenological and microscopic theories for catch bonds. |
Q58688346 | Poly(amidoamine) Hydrogels as Scaffolds for Cell Culturing and Conduits for Peripheral Nerve Regeneration |
Q37374292 | Protein Mechanics: A New Frontier in Biomechanics |
Q36909836 | Purification, analysis, and crystal structure of integrins |
Q33616477 | Recreation of the terminal events in physiological integrin activation |
Q34125138 | Regulation of Catch Binding by Allosteric Transitions |
Q37324659 | Regulation of integrin activity and signalling |
Q33954244 | Role of altered sialylation of the I-like domain of beta1 integrin in the binding of fibronectin to beta1 integrin: thermodynamics and conformational analyses |
Q37540219 | Rolling cell adhesion |
Q37780682 | Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis |
Q37779877 | Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing |
Q51431947 | Structural Insight for Roles of DR5 Death Domain Mutations on Oligomerization of DR5 Death Domain-FADD Complex in the Death-Inducing Signaling Complex Formation: A Computational Study. |
Q43014937 | Structural insight for the roles of fas death domain binding to FADD and oligomerization degree of the Fas-FADD complex in the death-inducing signaling complex formation: a computational study |
Q30622385 | Structurally governed cell mechanotransduction through multiscale modeling |
Q36744293 | Structure and mechanics of integrin-based cell adhesion. |
Q27653293 | Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces |
Q41489885 | Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling |
Q33348048 | T cell receptor triggering by force |
Q42582837 | Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins |
Q64907768 | The Cytoskeleton-A Complex Interacting Meshwork. |
Q33381441 | The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend |
Q39552692 | The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations. |
Q35751058 | The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18 |
Q90013704 | The bioenergetics of integrin-based adhesion, from single molecule dynamics to stability of macromolecular complexes |
Q50940275 | The effect of the physical properties of the substrate on the kinetics of cell adhesion and crawling studied by an axisymmetric diffusion-energy balance coupled model. |
Q34106011 | The final steps of integrin activation: the end game |
Q38739038 | The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes. |
Q37550239 | The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions |
Q49806464 | The human platelet antigen-1b variant of αIIbβ3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state |
Q47153377 | The involvement of the laminin-integrin α7β1 signaling pathway in mechanical ventilation-induced pulmonary fibrosis |
Q37998158 | The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties |
Q37360851 | The mechanical integrin cycle. |
Q47959485 | Understanding the Functional Roles of Multiple Extracellular Domains in Cell Adhesion Molecules with a Coarse-Grained Model |
Q97526629 | When Stiffness Matters: Mechanosensing in Heart Development and Disease |
Q50492543 | α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes. |
Q91929786 | β1 integrin is a sensor of blood flow direction |