scholarly article | Q13442814 |
P50 | author | Paul Mould | Q71246104 |
Martin J. Humphries | Q38799523 | ||
Mark A. Travis | Q56015652 | ||
P2093 | author name string | Janet A Askari | |
Richard A Kammerer | |||
Patrick A Buckley | |||
Stephanie J Barton | |||
Susan E Craig | |||
Jennifer A Hamilton | |||
Philip R Macdonald | |||
P2860 | cites work | Crystal structure of the extracellular segment of integrin alpha Vbeta3 | Q24291661 |
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand | Q24292425 | ||
A novel adaptation of the integrin PSI domain revealed from its crystal structure | Q24300709 | ||
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation | Q27638359 | ||
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face | Q27639651 | ||
Structure of the semaphorin-3A receptor binding module | Q27641852 | ||
Integrins: bidirectional, allosteric signaling machines | Q27860700 | ||
Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium | Q71823689 | ||
The 'ligand-induced conformational change' of alpha 5 beta 1 integrin. Relocation of alpha 5 subunit to uncover the beta 1 stalk region | Q74588320 | ||
Integrin avidity regulation: are changes in affinity and conformation underemphasized? | Q28205914 | ||
Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state | Q28208648 | ||
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2). | Q31628426 | ||
Localisation of a novel adhesion blocking epitope on the human beta 1 integrin chain | Q32005245 | ||
Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation | Q33292334 | ||
Thrombocytopenia resulting from sensitivity to GPIIb-IIIa inhibitors. | Q33363382 | ||
FRET detection of cellular alpha4-integrin conformational activation. | Q34183992 | ||
Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin | Q34378163 | ||
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand | Q34805673 | ||
An unraveling tale of how integrins are activated from within. | Q35111644 | ||
New insights into the structural basis of integrin activation. | Q35114650 | ||
Mapping functional residues onto integrin crystal structures. | Q35119761 | ||
Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble | Q35162578 | ||
Therapeutic antagonists and conformational regulation of integrin function | Q35209992 | ||
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics | Q35213036 | ||
Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? | Q35885645 | ||
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions | Q36601714 | ||
The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation | Q37593131 | ||
Structure of integrin alpha5beta1 in complex with fibronectin | Q39958701 | ||
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction | Q40566983 | ||
Novel activating and inactivating mutations in the integrin beta1 subunit A domain. | Q40589353 | ||
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides | Q40606401 | ||
Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chain | Q41045839 | ||
Control of beta1 integrin function. Localization of stimulatory epitopes | Q41229045 | ||
Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+. | Q41272684 | ||
Probing chemical and conformational differences in the resting and active conformers of platelet integrin alpha(IIb)beta(3). | Q41723052 | ||
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit | Q42066333 | ||
Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1. | Q42122844 | ||
Generation of a minimal alpha5beta1 integrin-Fc fragment | Q43627902 | ||
Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain | Q43917527 | ||
Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexes | Q44117638 | ||
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling | Q44136286 | ||
Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. | Q44610044 | ||
Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation | Q44912917 | ||
Insights into function of PSI domains from structure of the Met receptor PSI domain | Q45052351 | ||
Domains in plexins: links to integrins and transcription factors | Q55136031 | ||
Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies | Q57987231 | ||
Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement | Q58057915 | ||
The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy | Q58058153 | ||
Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit | Q58058190 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | antibody | Q79460 |
P304 | page(s) | 4238-4246 | |
P577 | publication date | 2004-11-22 | |
P1433 | published in | Journal of Biological Chemistry | Q867727 |
P1476 | title | Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension | |
P478 | volume | 280 |
Q35528037 | Activation of beta1 integrins on blood eosinophils by P-selectin |
Q26853383 | Activation states of blood eosinophils in asthma |
Q30157382 | An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment. |
Q36630280 | Anti-IL-5 attenuates activation and surface density of β(2) -integrins on circulating eosinophils after segmental antigen challenge. |
Q34987342 | Conformational mAb as a tool for integrin ligand discovery |
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Q42001098 | Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors. |
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Q39555000 | Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking |
Q43075851 | Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation. |
Q30434743 | Focal adhesions are sites of integrin extension |
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Q38611243 | Low affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection |
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Q34236673 | Modulation of integrin activation by an entropic spring in the {beta}-knee |
Q37930496 | Overview: assays for studying integrin-dependent cell adhesion. |
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Q38022543 | Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions |
Q38294282 | Quantification of integrin receptor agonism by fluorescence lifetime imaging |
Q39878470 | Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation |
Q37086651 | Relating conformation to function in integrin α5β1. |
Q36955887 | Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma |
Q29617618 | Structural basis of integrin regulation and signaling |
Q35951243 | Tests of the extension and deadbolt models of integrin activation |
Q46555259 | The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution. |
Q36980346 | Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challenge |