A novel adaptation of the integrin PSI domain revealed from its crystal structure

scientific article

A novel adaptation of the integrin PSI domain revealed from its crystal structure is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.C400362200
P8608Fatcat IDrelease_p5o4tuktdbfnjdji4wpglncuxe
P3181OpenCitations bibliographic resource ID3147541
P698PubMed publication ID15299032
P5875ResearchGate publication ID8412155

P50authorThilo StehleQ1473254
P2093author name stringJian-Ping Xiong
M Amin Arnaout
Simon L Goodman
P2860cites workCrystal structure of the extracellular segment of integrin alpha Vbeta3Q24291661
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligandQ24292425
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptorQ24294589
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4DQ27641965
Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoidQ27729942
Integrins: bidirectional, allosteric signaling machinesQ27860700
Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injuryQ28191775
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).Q31628426
Platelets: New Understanding of Platelet Glycoproteins and Their Role in Disease.Q33339720
A site involving the "hybrid" and PSI homology domains of GPIIIa (beta 3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopeniaQ33344847
Molecular dynamics applied to X-ray structure refinementQ34524168
Integrin structure: new twists and turns in dynamic cell adhesionQ34862258
New insights into the structural basis of integrin activation.Q35114650
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunitQ42066333
Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin familyQ42860255
Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexesQ44117638
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signalingQ44136286
A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis.Q51037257
Domains in plexins: links to integrins and transcription factorsQ55136031
P433issue39
P407language of work or nameEnglishQ1860
P921main subjectcrystal structureQ895901
P304page(s)40252-4
P577publication date2004-09-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleA novel adaptation of the integrin PSI domain revealed from its crystal structure
P478volume279

Reverse relations

cites work (P2860)
Q42924626A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia
Q33371168A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1.
Q27648837A novel structural fold in polysaccharide lyases: Bacillus subtilis family 11 rhamnogalacturonan lyase YesW with an eight-bladed beta-propeller
Q42011575A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream.
Q27646942A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins
Q50946720Activation mechanisms of αVβ3 integrin by binding to fibronectin: A computational study.
Q42270090Activation of integrins by urea in perfused rat liver
Q46863339Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity
Q27644491Characterization and NMR solution structure of a novel cyclic pentapeptide inhibitor of pathogenic hantaviruses
Q34055504Conservation of the human integrin-type beta-propeller domain in bacteria
Q36363957Conserved fiber-penton base interaction revealed by nearly atomic resolution cryo-electron microscopy of the structure of adenovirus provides insight into receptor interaction
Q39804477Cryo-electron microscopy structure of an adenovirus-integrin complex indicates conformational changes in both penton base and integrin
Q27657149Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment
Q35435784Early chordate origin of the vertebrate integrin αI domains
Q33885186Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3.
Q42542148Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.
Q33377595Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies.
Q43088558Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3.
Q30493944Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.
Q37855345Integrin structure, activation, and interactions
Q36564206Integrin structures and conformational signaling
Q27678003Integrin α1 Has a Long Helix, Extending from the Transmembrane Region to the Cytoplasmic Tail in Detergent Micelles
Q38611243Low affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection
Q35804502Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation
Q34753116Metal ion and ligand binding of integrin α5β1
Q27334036Molecular dynamics simulations of forced unbending of integrin α(v)β₃
Q33327051Multivalent presentation of antihantavirus peptides on nanoparticles enhances infection blockade
Q36806108Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3.
Q33465394Phage display selection of cyclic peptides that inhibit Andes virus infection
Q28068448Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies
Q48715103Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release
Q38022543Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions
Q33584613Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.
Q36909836Purification, analysis, and crystal structure of integrins
Q33375999Rapid detection of HPA-1 alloantibodies by platelet antigens immobilized onto microbeads
Q43188550Rationally designed integrin beta3 mutants stabilized in the high affinity conformation
Q46437880Retrospective molecular docking study of WY-25105 ligand to β-secretase and bias of the three-dimensional structure flexibility.
Q34787978Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function
Q36754146Small molecule inhibitors of hantavirus infection
Q29617618Structural basis of integrin regulation and signaling
Q34153526Structural diversity in integrin/talin interactions
Q36744293Structure and mechanics of integrin-based cell adhesion.
Q27653293Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces
Q39718617Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Q42582837Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins
Q36580090Targeting integrin structure and function in disease
Q35751058The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18
Q46555259The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution.
Q34541685The effect of the single substitution of arginine within the RGD tripeptide motif of a modified neurotoxin dendroaspin on its activity of platelet aggregation and cell adhesion
Q49806464The human platelet antigen-1b variant of αIIbβ3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state
Q46427663The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy
Q37604903The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy.
Q34044821The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins
Q36321549Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin
Q41620098Three-dimensional model of human platelet integrin alphaIIb beta3 in solution obtained by small angle neutron scattering
Q27674776α(V)β(3) integrin crystal structures and their functional implications
Q50492543α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes.
Q35708899β3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons

Search more.