| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2003PNAS..100.2403L |
| P356 | DOI | 10.1073/PNAS.0438060100 |
| P8608 | Fatcat ID | release_oxcfyr55j5fxfc57pfczlllcni |
| P932 | PMC publication ID | 151353 |
| P698 | PubMed publication ID | 12604783 |
| P5875 | ResearchGate publication ID | 10884039 |
| P2093 | author name string | Timothy A Springer | |
| Junichi Takagi | |||
| Bing-Hao Luo | |||
| P2860 | cites work | Crystal structure of the extracellular segment of integrin alpha Vbeta3 | Q24291661 |
| Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand | Q24292425 | ||
| Conformation and function of the N-linked glycan in the adhesion domain of human CD2 | Q24307801 | ||
| Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone | Q27634668 | ||
| Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation | Q27638359 | ||
| Structure of the extracellular region of HER3 reveals an interdomain tether | Q27639450 | ||
| SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling | Q27860614 | ||
| Integrins: bidirectional, allosteric signaling machines | Q27860700 | ||
| Binding of a fibrinogen mimetic stabilizes integrin alphaIIbbeta3's open conformation | Q28344771 | ||
| Ribbons | Q29614460 | ||
| ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling | Q29617090 | ||
| Conformational regulation of integrin structure and function | Q34623640 | ||
| Engineering and design of ligand-induced conformational change in proteins | Q34774278 | ||
| Long range propagation of conformational changes in integrin alpha IIb beta 3 | Q36697562 | ||
| Manipulation of ligand binding affinity by exploitation of conformational coupling | Q38297402 | ||
| Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. | Q41226672 | ||
| Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit | Q42066333 | ||
| Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization | Q42612916 | ||
| Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling | Q44136286 | ||
| Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3. | Q44212493 | ||
| Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. | Q46027752 | ||
| Regulation of conformation and ligand binding function of integrin alpha5beta1 by the beta1 cytoplasmic domain | Q46599137 | ||
| Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines | Q58065088 | ||
| Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy | Q68236674 | ||
| Sodium dodecyl sulfate-stable complexes of echistatin and RGD-dependent integrins: a novel approach to study integrins | Q73097990 | ||
| Integrin alphaIIb beta3 reconstituted into lipid bilayers is nonclustered in its activated state but clusters after fibrinogen binding | Q73453575 | ||
| C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1 | Q73808273 | ||
| Classification of 'activation' antibodies against integrin beta1 chain | Q73879359 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2403-2408 | |
| P577 | publication date | 2003-02-25 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand | |
| P478 | volume | 100 |
| Q45099239 | A 50-A separation of the integrin alpha v beta 3 extracellular domain C termini reveals an intermediate activation state |
| Q46699057 | A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation |
| Q42238933 | A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. |
| Q24793060 | A specific interface between integrin transmembrane helices and affinity for ligand |
| Q40516746 | ADP-ribosylation of integrin alpha7 modulates the binding of integrin alpha7beta1 to laminin |
| Q33809484 | Acidic extracellular pH promotes activation of integrin α(v)β(3). |
| Q50946720 | Activation mechanisms of αVβ3 integrin by binding to fibronectin: A computational study. |
| Q36601714 | Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions |
| Q44881202 | Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain |
| Q46863339 | Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity |
| Q51033743 | Blood type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells. |
| Q27678790 | Complete integrin headpiece opening in eight steps |
| Q28593539 | Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions |
| Q33928601 | Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. |
| Q42542148 | Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. |
| Q38102415 | Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology. |
| Q36642706 | Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. |
| Q33571529 | Glanzmann thrombasthenia: state of the art and future directions |
| Q39789994 | Glycans in melanoma screening. Part 2. Towards the understanding of integrin N-glycosylation in melanoma. |
| Q36458316 | Guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme |
| Q42437423 | High affinity ligand binding by integrins does not involve head separation |
| Q30480541 | How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation |
| Q34352394 | Identification of Interacting Hot Spots in the β3 Integrin Stalk Using Comprehensive Interface Design |
| Q37031940 | Identification of integrin beta subunit mutations that alter heterodimer function in situ |
| Q35939722 | Identification, characterization, and epitope mapping of human monoclonal antibody J19 that specifically recognizes activated integrin α4β7. |
| Q35266840 | Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy |
| Q37479425 | Integrin activation dynamics between the RGD-binding site and the headpiece hinge |
| Q37512992 | Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation |
| Q93064944 | Integrin nanoclusters can bridge thin matrix fibres to form cell-matrix adhesions |
| Q37855345 | Integrin structure, activation, and interactions |
| Q36564206 | Integrin structures and conformational signaling |
| Q33290835 | Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli |
| Q24299829 | Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions |
| Q37810633 | Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation |
| Q42802396 | Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions |
| Q34302948 | Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. |
| Q42471012 | LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils |
| Q40606401 | Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides |
| Q56889514 | Mechano-redox control of integrin de-adhesion |
| Q46465757 | Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activation |
| Q36089893 | Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis |
| Q34236673 | Modulation of integrin activation by an entropic spring in the {beta}-knee |
| Q39441019 | Mutagenesis studies of the β I domain metal ion binding sites on integrin αVβ3 ligand binding affinity |
| Q40608458 | Mutations in and near the second calcium-binding domain of integrin alphaIIb affect the structure and function of integrin alphaIIbbeta3. |
| Q39377016 | N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4. |
| Q40238492 | N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration |
| Q52325843 | On the contributing role of the transmembrane domain for subunit-specific sensitivity of integrin activation. |
| Q43188550 | Rationally designed integrin beta3 mutants stabilized in the high affinity conformation |
| Q35651723 | Reconstruction of integrin activation |
| Q36007725 | Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling |
| Q34093237 | Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2 |
| Q40566983 | Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction |
| Q35125022 | Selective targeting of TGF-β activation to treat fibroinflammatory airway disease |
| Q41500222 | Structural Requirements for Activation in αIIbβ3 Integrin |
| Q35213036 | Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics |
| Q29617618 | Structural basis of integrin regulation and signaling |
| Q27301036 | Swing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogen |
| Q42582837 | Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins |
| Q34503113 | Tests of Integrin Transmembrane Domain Homo-oligomerization during Integrin Ligand Binding and Signaling |
| Q35951243 | Tests of the extension and deadbolt models of integrin activation |
| Q35751058 | The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18 |
| Q33875329 | The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation |
| Q37360851 | The mechanical integrin cycle. |
| Q40358354 | The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells |
| Q38724224 | The nucleus is a conserved mechanosensation and mechanoresponse organelle. |
| Q35215649 | The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. |
| Q35925845 | The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion |
| Q35209992 | Therapeutic antagonists and conformational regulation of integrin function |
| Q39950698 | Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms |
| Q39401120 | Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner |
| Q37415579 | Use of sequence duplication to engineer a ligand-triggered, long-distance molecular switch in T4 lysozyme |
| Q35014901 | Variation in one residue associated with the metal ion-dependent adhesion site regulates αIIbβ3 integrin ligand binding affinity |
| Q34661939 | Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. |
| Q27674776 | α(V)β(3) integrin crystal structures and their functional implications |
| Q36744522 | β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece |
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