Martin J. Humphries

researcher

Martin J. Humphries is …
instance of (P31):
humanQ5

External links are
P5463AE member IDHumphries_Martin
P8446Gateway to Research person ID6A41F8A1-82D2-49F0-A212-A09482450C91
P496ORCID iD0000-0002-4331-6967
P1153Scopus author ID7101607625

P734family nameHumphriesQ1393924
HumphriesQ1393924
HumphriesQ1393924
P735given nameMartinQ18002399
MartinQ18002399
P463member ofAcademia EuropaeaQ337234
P106occupationresearcherQ1650915
P21sex or gendermaleQ6581097

Reverse relations

author (P50)
Q112299502A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
Q45713868A novel gain-of-function mutation of the integrin alpha2 VWFA domain
Q30619651A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting
Q57007980A secondary structure model of the integrin alpha subunit N-terminal domain based on analysis of multiple alignments
Q42238933A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.
Q52278175A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.
Q38840428A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis
Q40452698Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells.
Q58057878Adhesion articulated
Q41864387Adhesion signalling complexes
Q41740840Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.
Q36081745Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs
Q33799228Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
Q43008808Alternative cellular roles for proteins identified using proteomics
Q38292243Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading.
Q38330359Amino acid motifs required for isolated beta cytoplasmic domains to regulate 'in trans' beta1 integrin conformation and function in cell attachment.
Q58058093An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity
Q58058307An assessment of the effects of swainsonine on survival of mice injected with B16-F10 melanoma cells
Q41045395Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes
Q24594263Anti-integrin monoclonal antibodies
Q58058103Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1
Q24797279Calpha-H...O = C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions
Q58057776Cell Adhesion Assays
Q58057959Cell Adhesion Assays
Q58057607Cell adhesion is regulated by CDK1 during the cell cycle
Q38303515Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.
Q58057964Cell-Substrate Adhesion Assays
Q58057746Cell-to-cell contact and extracellular matrix
Q38668699Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics
Q92823591Clathrin-containing adhesion complexes
Q24339581Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
Q41042587Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.
Q58058242Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge
Q42834201Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I.
Q58057915Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement
Q38719428Conformational equilibria and intrinsic affinities define integrin activation.
Q92732465Connections between the cell cycle, cell adhesion and the cytoskeleton
Q22009026Crystal structure of a heparin- and integrin-binding segment of human fibronectin.
Q39540623Cyclic mechanical reinforcement of integrin-ligand interactions
Q24534902Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling
Q57987231Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies
Q38910230Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling
Q37267611Demonstration of catch bonds between an integrin and its ligand.
Q58058121Direct Role of the Carboxy-Terminal Cell-Binding Domain of Fibronectin in Neural Crest Cell Motility
Q42001098Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.
Q37353150Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.
Q41677058Distinct mechanism of human neuroblastoma cell adhesion to fibronectin
Q41788612Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.
Q39555000Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking
Q49259360DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern
Q40838241Dynamic aspects of adhesion receptor function--integrins both twist and shout
Q58057935E-cadherin is a ligand for integrin α2β1
Q100737208ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells
Q41370423Effect of beta-mercaptoethanol on the detection of biotinylated proteins
Q38315553Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.
Q35196346Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.
Q40384255Evidence for the presence of a low-mass beta1 integrin on the cell surface.
Q42542148Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.
Q41426502Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.
Q40788897Fibronectin and cancer: rationales for the use of antiadhesives in cancer treatment.
Q45950943Fibronectin is a survival factor for differentiated osteoblasts.
Q40464537Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.
Q38789394Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro
Q40422808Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling
Q42995232Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.
Q30434743Focal adhesions are sites of integrin extension
Q40886268Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.
Q58057795Functional role of β1 integrin-mediated signalling in the human hair follicle
Q43627902Generation of a minimal alpha5beta1 integrin-Fc fragment
Q27342741Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization
Q37513952Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour
Q37733558Global analysis reveals the complexity of the human glomerular extracellular matrix
Q37733606Glomerular cell cross-talk influences composition and assembly of extracellular matrix
Q34236515Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site
Q58058295Human natural killer cells express VLA-4 and VLA-5, which mediate their adhesion to fibronectin
Q39294242IQGAP1 is a key node within the small GTPase network
Q58058049Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1
Q48080719Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin
Q58058190Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit
Q43540787Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants
Q35936952Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin
Q58058023Identification of fibronectin IIICS variants in human bone marrow stroma
Q56837683Identification of heparin as a ligand for the A-domain of Plasmodium falciparum thrombospondin-related adhesion protein
Q58058227Identification of integrin alpha 2 beta 1 as cell surface receptor for the carboxyl-terminal propeptide of type I procollagen
Q33247353Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)
Q58057611Improved LC-MS chromatographic alignment increases the accuracy of label-free quantitative proteomics: Comparison of spectral counting versus ion intensity-based proteomic quantification strategies
Q58058085Influence of interleukin-3 and other growth factors on alpha4beta1 integrin-mediated adhesion and migration of human hematopoietic progenitor cells
Q34731123Insights into integrin-ligand binding and activation from the first crystal structure.
Q97564836Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates
Q43917527Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain
Q40924680Integrin activation: the link between ligand binding and signal transduction
Q41105457Integrin adhesion receptors: structure, function and implications for biomedicine
Q58058215Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin
Q33818947Integrin cell adhesion receptors and the concept of agonism.
Q24600618Integrin ligands at a glance
Q58058029Integrin signalling defects in T-lymphocytes in systemic lupus erythematosus
Q37855345Integrin structure, activation, and interactions
Q28566198Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons
Q36323393Integrin-specific signaling pathways controlling focal adhesion formation and cell migration.
Q42488009Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading.
Q41879521Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation.
Q40744141Integrins: a review of their structure and mechanisms of ligand binding.
Q33292334Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation
Q42762304Interaction of the α2A domain of integrin with small collagen fragments
Q39656135Investigation of the antimetastatic effects of agents that inhibit cell adhesion or protein glycosylation
Q39776870Isolation of integrin-based adhesion complexes
Q30826108Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.
Q58058277Lymphocyte adhesion to high endothelium is mediated by two beta 1 integrin receptors for fibronectin, alpha 4 beta 1 and alpha 5 beta 1
Q35119761Mapping functional residues onto integrin crystal structures.
Q41963794Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.
Q28291307Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design
Q35922901Mechanisms of integration of cells and extracellular matrices by integrins.
Q58058234Mechanisms of ligand binding by integrins
Q34744466Microtubule-dependent modulation of adhesion complex composition
Q39783486Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP).
Q58058109Molecular Characterisation of Integrin-Procollagen C-Propeptide Interactions
Q40719321Molecular and cellular biology of integrins
Q34187777Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction.
Q37372196Molecular interplay between endostatin, integrins, and heparan sulfate.
Q35780406Monoclonal antibodies as probes of integrin priming and activation.
Q42997362Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1.
Q36218423Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment
Q27331901Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
Q40589353Novel activating and inactivating mutations in the integrin beta1 subunit A domain.
Q42677623PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic
Q30829771PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.
Q36058193Peptide recognition motifs involved in the binding of integrins to their ligands
Q58057814Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal α5 integrin
Q40886543Production of recombinant soluble human integrin alpha4beta1.
Q28728604Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver
Q34176055Proteomic analysis of integrin adhesion complexes
Q36532532Proteomic analysis of integrin-associated complexes from mesenchymal stem cells
Q24314482Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6
Q28727031Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment
Q38935123Proteomic definitions of basement membrane composition in health and disease
Q93116504Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
Q30544964RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex
Q24296948Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
Q28680758Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway
Q39498352Recent advances in research on fibronectin and other cell attachment proteins
Q41037592Recent insights into ligand binding, activation and signalling by integrin adhesion receptors
Q58058008Recruitment of a Heparan Sulfate Subunit to the Interleukin-1 Receptor Complex
Q36321377Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.
Q46975937Regulation of integrin activity by MIA.
Q41272684Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.
Q35885645Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?
Q42122844Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.
Q58058044Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin
Q47935070Regulation of the extracellular ligand binding activity of integrins.
Q37086651Relating conformation to function in integrin α5β1.
Q42803034Requirement for Rho in integrin signalling.
Q58057603Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis
Q44610044Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.
Q27005769Role of adhesion receptor trafficking in 3D cell migration
Q24338618SHARPIN is an endogenous inhibitor of β1-integrin activation
Q24537649Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.
Q58058371Stimulation of DNA synthesis by cathepsin D digests of fibronectin
Q58058341Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: Immunomodulatory properties
Q44519392Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.
Q43764751Structure. An anthropomorphic integrin
Q58058321Swainsonine Inhibition of Spontaneous Metastasis
Q43219412Syndecan-4 phosphorylation is a control point for integrin recycling.
Q36986535Synergistic control of cell adhesion by integrins and syndecans.
Q43607849T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint
Q51803883The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.
Q58058138The A-Domain of Integrin alpha2 Binds Specifically to a Range of Collagens but is not a General Receptor for the Collagenous Motif
Q58058153The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy
Q58058124The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin
Q38642362The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Q36365185The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1
Q39336124The cell interaction sites of fibronectin in tumour metastasis
Q41490672The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins
Q58058065The effect of alpha4 beta1-integrin binding sequences of fibronectin on growth of cells from human hematopoietic progenitors
Q41573400The effect of peptide adsorption on signal linearity and a simple approach to improve reliability of quantification
Q38263509The importance of podocyte adhesion for a healthy glomerulus
Q28077380The integrin adhesome network at a glance
Q48022417The integrin beta subunit
Q24810343The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.
Q34595466The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.
Q47721589The structure of cell-adhesion molecules
Q30490516Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1
Q41618972Unique expression of integrin fibronectin receptors in human neuroblastoma cell lines
Q39609912Use of antiadhesive peptide and swainsonine to inhibit metastasis
Q41970148Use of synthetic peptides to probe lymphocyte--high endothelial cell interactions. Lymphocytes recognize a ligand on the endothelial surface which contains the CS1 adhesion motif
Q42475325VCAM-1 is a CS1 peptide-inhibitable adhesion molecule expressed by lymph node high endothelium
Q56915094α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1
Q35080919β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny

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