Recent advances in our understanding of receptor binding, viral fusion and cell entry of hepatitis C virus: new targets for the design of antiviral agents

scientific article published on January 2007

Recent advances in our understanding of receptor binding, viral fusion and cell entry of hepatitis C virus: new targets for the design of antiviral agents is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1177/095632020701800402
P698PubMed publication ID17907376
P5875ResearchGate publication ID5938315

P2093author name stringHeidi E Drummer
Pantelis Poumbourios
P2860cites workBinding of hepatitis C virus to CD81Q22004178
DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2Q24296260
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virusQ24307963
Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2.Q24524809
Structure-function analysis of hepatitis C virus envelope-CD81 bindingQ24525189
Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNRQ24551041
Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivityQ24672232
Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexesQ24673768
Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type IQ24676039
OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytesQ24680419
Structure of dengue virus: implications for flavivirus organization, maturation, and fusionQ24736810
Translation of the F protein of hepatitis C virus is initiated at a non-AUG codon in a +1 reading frame relative to the polyproteinQ24795677
Peptide inhibitors of dengue virus and West Nile virus infectivityQ24813811
Characterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptorQ27469307
Functional characterization of intracellular and secreted forms of a truncated hepatitis C virus E2 glycoproteinQ27469621
Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infectionQ27469669
Conservation of the Conformation and Positive Charges of Hepatitis C Virus E2 Envelope Glycoprotein Hypervariable Region 1 Points to a Role in Cell AttachmentQ27469804
An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing AntibodiesQ27469837
Robust hepatitis C virus infection in vitroQ27470013
Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope GlycoproteinQ27470798
Analysis of a Highly Flexible Conformational Immunogenic Domain A in Hepatitis C Virus E2Q27472672
Basic residues in hypervariable region 1 of hepatitis C virus envelope glycoprotein e2 contribute to virus entryQ27472768
Identification of the hepatitis C virus E2 glycoprotein binding site on the large extracellular loop of CD81Q27472909
Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered EntryQ27472926
Association between Hepatitis C Virus and Very-Low-Density Lipoprotein (VLDL)/LDL Analyzed in Iodixanol Density GradientsQ27473044
CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.Q27473055
Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes.Q27473066
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cellsQ27473106
Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle EntryQ27473222
Production of infectious hepatitis C virus particles in three-dimensional cultures of the cell line carrying the genome-length dicistronic viral RNA of genotype 1b.Q40282946
SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux.Q40314409
Contribution of the charged residues of hepatitis C virus glycoprotein E2 transmembrane domain to the functions of the E1E2 heterodimer.Q40368608
Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteinsQ40374927
Determinants of CD81 dimerization and interaction with hepatitis C virus glycoprotein E2.Q40465898
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent mannerQ40530808
Incomplete humoral immunity against hepatitis C virus is linked with distinct recognition of putative multiple receptors by E2 envelope glycoproteinQ40542685
Cell surface expression of functional hepatitis C virus E1 and E2 glycoproteinsQ40555914
Hepatitis C virus glycoprotein E2 contains a membrane-proximal heptad repeat sequence that is essential for E1E2 glycoprotein heterodimerization and viral entryQ40557371
Proteomics computational analyses suggest that hepatitis C virus E1 and pestivirus E2 envelope glycoproteins are truncated class II fusion proteinsQ40562324
Small molecule inhibition of hepatitis C virus E2 binding to CD81Q40630400
SR-BI does not require raft/caveola localisation for cholesteryl ester selective uptake in the human adrenal cell line NCI-H295R.Q40672230
Cholesteryl ester is transported from caveolae to internal membranes as part of a caveolin-annexin II lipid-protein complexQ40762364
Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2.Q40791868
The C-terminal region of the hepatitis C virus E1 glycoprotein confers localization within the endoplasmic reticulumQ40932523
Mechanism of scavenger receptor class B type I-mediated selective uptake of cholesteryl esters from high density lipoprotein to adrenal cellsQ40943012
Hepatitis C virus glycoprotein complex localization in the endoplasmic reticulum involves a determinant for retention and not retrieval.Q40993767
Characterization of truncated forms of hepatitis C virus glycoproteins.Q41091382
Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells.Q42820160
Characterization of hypervariable regions in the putative envelope protein of hepatitis C virusQ42982262
Hepatitis C virus: buoyant density of the factor VIII-derived isolate in sucroseQ42984652
Antigenic relevance of F protein in chronic hepatitis C virus infectionQ42987731
Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cellsQ42999644
High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI.Q42999970
Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoproteinQ43000686
In vitro interaction between hepatitis C virus (HCV) envelope glycoprotein E2 and serum lipoproteins (LPs) results in enhanced cellular binding of both HCV E2 and LPs.Q43031590
Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C.Q43031823
Mutagenesis of a conserved fusion peptide-like motif and membrane-proximal heptad-repeat region of hepatitis C virus glycoprotein E1.Q43036612
Genetic alteration of the hepatitis C virus hypervariable region obtained from an asymptomatic carrierQ43048602
Mutations within the CD81-binding sites and hypervariable region 2 of the envelope 2 protein: correlation with treatment response in hepatitis C virus-infected patientsQ43049101
Density heterogeneities of hepatitis C virus in human sera due to the binding of beta-lipoproteins and immunoglobulinsQ43049359
Cyanovirin-N inhibits AIDS virus infections in vaginal transmission modelsQ45670260
Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co-stimulatory signal for human T cellsQ45738814
A new determinant of endoplasmic reticulum localization is contained in the juxtamembrane region of the ectodomain of hepatitis C virus glycoprotein E1.Q45742812
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter VirusesQ27473226
Hepatitis C Virus Entry Depends on Clathrin-Mediated EndocytosisQ27473290
L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virusQ27473455
The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivativesQ27477454
A Conserved Gly436-Trp-Leu-Ala-Gly-Leu-Phe-Tyr Motif in Hepatitis C Virus Glycoprotein E2 Is a Determinant of CD81 Binding and Viral EntryQ27477463
Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 BindingQ27477468
Viral and Cellular Determinants of the Hepatitis C Virus Envelope-Heparan Sulfate InteractionQ27477606
Diverse CD81 Proteins Support Hepatitis C Virus InfectionQ27477625
Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated VesiclesQ27477644
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particlesQ27477687
Immunogenic and Functional Organization of Hepatitis C Virus (HCV) Glycoprotein E2 on Infectious HCV VirionsQ27478035
The Level of CD81 Cell Surface Expression Is a Key Determinant for Productive Entry of Hepatitis C Virus into Host CellsQ27478044
Transmembrane Domains of Hepatitis C Virus Envelope Glycoproteins: Residues Involved in E1E2 Heterodimerization and Involvement of These Domains in Virus EntryQ27478363
CD81 Expression Is Important for the Permissiveness of Huh7 Cell Clones for Heterogeneous Hepatitis C Virus InfectionQ27480351
Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious VirusQ27481018
Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope ProteinQ27485143
Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell FunctionsQ27485145
Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptorQ27485871
Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 proteinQ27487933
Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzeesQ27489101
The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerizationQ27622511
The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pHQ27631190
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virusQ27643010
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformationQ27643140
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolutionQ27730234
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Complete replication of hepatitis C virus in cell cultureQ27860934
Receptor binding and membrane fusion in virus entry: the influenza hemagglutininQ27861017
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entryQ28131832
Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptorQ28200972
C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particlesQ28263849
Identification of scavenger receptor SR-BI as a high density lipoprotein receptorQ28273182
Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolaeQ28513709
The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipidsQ28678353
Binding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2.Q29048140
CD81 is an entry coreceptor for hepatitis C virusQ29614812
Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virusQ29619744
CD81 is required for hepatitis C virus glycoprotein-mediated viral infectionQ29619745
Unravelling hepatitis C virus replication from genome to functionQ29620056
The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, AmantadineQ29620670
Structural characterization of peptide fragments from hCD81-LEL.Q30756955
Phage display selection on whole cells yields a small peptide specific for HCV receptor human CD81.Q33196894
The membrane-active regions of the hepatitis C virus E1 and E2 envelope glycoproteins.Q33236239
Multiple antiviral activities of cyanovirin-N: blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped virusesQ33804363
Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1Q33934442
Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI.Q33953583
Cyanovirin-N, a potent human immunodeficiency virus-inactivating protein, blocks both CD4-dependent and CD4-independent binding of soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of sgp120 to cell-associated CXCR4, and dissociaQ33981547
Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C.Q34152354
Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in transQ34230933
The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid tradersQ34273619
Characterization of infectious retroviral pseudotype particles bearing hepatitis C virus glycoproteinsQ34436127
Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivityQ34437763
HIV co-receptors as targets for antiviral therapyQ34547710
Dynamics of HIV neutralization by a microbicide formulation layer: biophysical fundamentals and transport theoryQ35012298
Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradationQ35704771
CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responsesQ35921103
Class II virus membrane fusion proteinsQ36346783
Normal lymphocyte development but delayed humoral immune response in CD81-null miceQ36377129
Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient miceQ36597251
Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonadQ37348207
L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virusQ37557428
High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.Q38332447
Localization and regulation of SR-BI in membrane rafts of HepG2 cellsQ38339437
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfateQ38352468
Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functionsQ39755223
Entry of hepatitis C virus pseudotypes into primary human hepatocytes by clathrin-dependent endocytosisQ40246185
Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycansQ40261250
P433issue4
P921main subjectHepatitis C virusQ708693
P304page(s)169-189
P577publication date2007-01-01
P1433published inAntiviral Chemistry & ChemotherapyQ2853412
P1476titleRecent advances in our understanding of receptor binding, viral fusion and cell entry of hepatitis C virus: new targets for the design of antiviral agents
P478volume18

Reverse relations

cites work (P2860)
Q37433442Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain
Q39955792Contribution of redox status to hepatitis C virus E2 envelope protein function and antigenicity
Q39812444Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes
Q27487974Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme
Q42259914The role of microRNAs in hepatitis C virus RNA replication
Q24654912microRNA-122 stimulates translation of hepatitis C virus RNA

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